Maternal prenatal stress and infant DNA methylation: A systematic review

Maternal prenatal stress has been linked to a variety of infant postnatal outcomes, partially through alterations in fetal HPA axis functioning; yet the underlying pathobiology remains elusive. Current literature posits DNA methylation as a candidate mechanism through which maternal prenatal stress...

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Veröffentlicht in:	Developmental psychobiology 2018-03, Vol.60 (2), p.127-139
Hauptverfasser:	Sosnowski, David W., Booth, Carolyn, York, Timothy P., Amstadter, Ananda B., Kliewer, Wendy
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Sprache:	eng
Schlagworte:	DNA methylation epigenetic prenatal stress systematic review
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container_title	Developmental psychobiology
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creator	Sosnowski, David W. Booth, Carolyn York, Timothy P. Amstadter, Ananda B. Kliewer, Wendy
description	Maternal prenatal stress has been linked to a variety of infant postnatal outcomes, partially through alterations in fetal HPA axis functioning; yet the underlying pathobiology remains elusive. Current literature posits DNA methylation as a candidate mechanism through which maternal prenatal stress can influence fetal HPA axis functioning. The goal of this systematic review was to summarize the literature examining the associations among maternal prenatal stress, DNA methylation of commonly studied HPA axis candidate genes, and infant HPA axis functioning. Results from the review provided evidence for a link between various maternal prenatal stressors, NR3C1 methylation, and infant stress reactivity, but findings among other genes were limited, with mixed results. An original study quality review tool revealed that a majority of studies in the review are adequate, and emphasizes the need for future research to consider study quality when interpreting research findings.
doi_str_mv	10.1002/dev.21604
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title	Maternal prenatal stress and infant DNA methylation: A systematic review
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