Photodynamic antimicrobial chemotherapy (PACT) using toluidine blue inhibits both growth and biofilm formation by Candida krusei
Among non-albicans Candida species, the opportunistic pathogen Candida krusei emerges because of the high mortality related to infections produced by this yeast. The Candida krusei is an opportunistic pathogen presenting an intrinsic resistance to fluconazol. In spite of the reduced number of infect...
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| Veröffentlicht in: | Lasers in medical science 2018-07, Vol.33 (5), p.983-990 |
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| creator | da Silva, Bruna Graziele Marques Carvalho, Moisés Lopes Rosseti, Isabela Bueno Zamuner, Stella Costa, Maricilia Silva |
| description | Among non-albicans Candida species, the opportunistic pathogen
Candida krusei
emerges because of the high mortality related to infections produced by this yeast. The
Candida krusei
is an opportunistic pathogen presenting an intrinsic resistance to fluconazol. In spite of the reduced number of infections produced by
C. krusei
, its occurrence is increasing in some groups of patients submitted to the use of fluconazol for prophylaxis. Photodynamic antimicrobial chemotherapy (PACT) is a potential antimicrobial therapy that combines visible light and a nontoxic dye, known as a photosensitizer, producing reactive oxygen species (ROS) that can kill the treated cells. The objective of this study was to investigate the effects of PACT, using toluidine blue, as a photosensitizer on both growth and biofilm formation by
Candida krusei
. In this work, we studied the effect of the PACT, using TB on both cell growth and biofilm formation by
C. krusei
. PACT was performed using a light source with output power of 0.068 W and peak wavelength of 630 nm, resulting in a fluence of 20, 30, or 40 J/cm
2
. In addition, ROS production was determined after PACT. The number of samples used in this study varied from 6 to 8. Statistical differences were evaluated by analysis of variance (ANOVA) and post hoc comparison with Tukey-Kramer test. PACT inhibited both growth and biofilm formation by
C. krusei
. It was also observed that PACT stimulated ROS production. Comparing to cells not irradiated, irradiation was able to increase ROS production in 11.43, 6.27, and 4.37 times, in the presence of TB 0.01, 0.02, and 0.05 mg/mL, respectively. These results suggest that the inhibition observed in the cell growth after PACT could be related to the ROS production, promoting cellular damage. Taken together, these results demonstrated the ability of PACT reducing both cell growth and biofilm formation by
C. krusei
. |
| doi_str_mv | 10.1007/s10103-017-2428-y |
| format | Article |
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Candida krusei
emerges because of the high mortality related to infections produced by this yeast. The
Candida krusei
is an opportunistic pathogen presenting an intrinsic resistance to fluconazol. In spite of the reduced number of infections produced by
C. krusei
, its occurrence is increasing in some groups of patients submitted to the use of fluconazol for prophylaxis. Photodynamic antimicrobial chemotherapy (PACT) is a potential antimicrobial therapy that combines visible light and a nontoxic dye, known as a photosensitizer, producing reactive oxygen species (ROS) that can kill the treated cells. The objective of this study was to investigate the effects of PACT, using toluidine blue, as a photosensitizer on both growth and biofilm formation by
Candida krusei
. In this work, we studied the effect of the PACT, using TB on both cell growth and biofilm formation by
C. krusei
. PACT was performed using a light source with output power of 0.068 W and peak wavelength of 630 nm, resulting in a fluence of 20, 30, or 40 J/cm
2
. In addition, ROS production was determined after PACT. The number of samples used in this study varied from 6 to 8. Statistical differences were evaluated by analysis of variance (ANOVA) and post hoc comparison with Tukey-Kramer test. PACT inhibited both growth and biofilm formation by
C. krusei
. It was also observed that PACT stimulated ROS production. Comparing to cells not irradiated, irradiation was able to increase ROS production in 11.43, 6.27, and 4.37 times, in the presence of TB 0.01, 0.02, and 0.05 mg/mL, respectively. These results suggest that the inhibition observed in the cell growth after PACT could be related to the ROS production, promoting cellular damage. Taken together, these results demonstrated the ability of PACT reducing both cell growth and biofilm formation by
C. krusei
.</description><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-017-2428-y</identifier><identifier>PMID: 29332258</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Anti-Bacterial Agents - pharmacology ; Anti-Infective Agents - pharmacology ; Antiinfectives and antibacterials ; Antimicrobial agents ; Biofilms ; Biofilms - drug effects ; Biofilms - growth & development ; Candida - drug effects ; Candida - growth & development ; Candida - physiology ; Candida krusei ; Cell growth ; Cellular manufacture ; Chemotherapy ; Dentistry ; Irradiation ; Lasers ; Light ; Light sources ; Medicine ; Medicine & Public Health ; Microbial Sensitivity Tests ; Opportunist infection ; Optical Devices ; Optics ; Original Article ; Pathogens ; Photochemotherapy ; Photonics ; Photosensitizing Agents - pharmacology ; Prophylaxis ; Quantum Optics ; Radiation ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Statistical analysis ; Statistical methods ; Tolonium Chloride - pharmacology ; Toluidine ; Toluidine blue ; Variance analysis ; Yeast</subject><ispartof>Lasers in medical science, 2018-07, Vol.33 (5), p.983-990</ispartof><rights>Springer-Verlag London Ltd., part of Springer Nature 2018</rights><rights>Lasers in Medical Science is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-e5481169033963da475c665c93ef5ccec0853683188b4f7d23ec3819b81b467b3</citedby><cites>FETCH-LOGICAL-c372t-e5481169033963da475c665c93ef5ccec0853683188b4f7d23ec3819b81b467b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-017-2428-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-017-2428-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29332258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Silva, Bruna Graziele Marques</creatorcontrib><creatorcontrib>Carvalho, Moisés Lopes</creatorcontrib><creatorcontrib>Rosseti, Isabela Bueno</creatorcontrib><creatorcontrib>Zamuner, Stella</creatorcontrib><creatorcontrib>Costa, Maricilia Silva</creatorcontrib><title>Photodynamic antimicrobial chemotherapy (PACT) using toluidine blue inhibits both growth and biofilm formation by Candida krusei</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><addtitle>Lasers Med Sci</addtitle><description>Among non-albicans Candida species, the opportunistic pathogen
Candida krusei
emerges because of the high mortality related to infections produced by this yeast. The
Candida krusei
is an opportunistic pathogen presenting an intrinsic resistance to fluconazol. In spite of the reduced number of infections produced by
C. krusei
, its occurrence is increasing in some groups of patients submitted to the use of fluconazol for prophylaxis. Photodynamic antimicrobial chemotherapy (PACT) is a potential antimicrobial therapy that combines visible light and a nontoxic dye, known as a photosensitizer, producing reactive oxygen species (ROS) that can kill the treated cells. The objective of this study was to investigate the effects of PACT, using toluidine blue, as a photosensitizer on both growth and biofilm formation by
Candida krusei
. In this work, we studied the effect of the PACT, using TB on both cell growth and biofilm formation by
C. krusei
. PACT was performed using a light source with output power of 0.068 W and peak wavelength of 630 nm, resulting in a fluence of 20, 30, or 40 J/cm
2
. In addition, ROS production was determined after PACT. The number of samples used in this study varied from 6 to 8. Statistical differences were evaluated by analysis of variance (ANOVA) and post hoc comparison with Tukey-Kramer test. PACT inhibited both growth and biofilm formation by
C. krusei
. It was also observed that PACT stimulated ROS production. Comparing to cells not irradiated, irradiation was able to increase ROS production in 11.43, 6.27, and 4.37 times, in the presence of TB 0.01, 0.02, and 0.05 mg/mL, respectively. These results suggest that the inhibition observed in the cell growth after PACT could be related to the ROS production, promoting cellular damage. Taken together, these results demonstrated the ability of PACT reducing both cell growth and biofilm formation by
C. krusei
.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial agents</subject><subject>Biofilms</subject><subject>Biofilms - drug effects</subject><subject>Biofilms - growth & development</subject><subject>Candida - drug effects</subject><subject>Candida - growth & development</subject><subject>Candida - physiology</subject><subject>Candida krusei</subject><subject>Cell growth</subject><subject>Cellular manufacture</subject><subject>Chemotherapy</subject><subject>Dentistry</subject><subject>Irradiation</subject><subject>Lasers</subject><subject>Light</subject><subject>Light sources</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microbial Sensitivity Tests</subject><subject>Opportunist infection</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Original Article</subject><subject>Pathogens</subject><subject>Photochemotherapy</subject><subject>Photonics</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Prophylaxis</subject><subject>Quantum Optics</subject><subject>Radiation</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Tolonium Chloride - pharmacology</subject><subject>Toluidine</subject><subject>Toluidine blue</subject><subject>Variance analysis</subject><subject>Yeast</subject><issn>0268-8921</issn><issn>1435-604X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc1q3DAUhUVp6EymfYBugqCbdOFEP5YsLcPQNoVAskggOyHJ8owmtjSRbIJ3ffQoTFpCIauzuN8993IOAF8xOsMINecZI4xohXBTkZqIav4AlrimrOKovv8IlohwUQlJ8AIc57xDBeSYfgILIiklhIkl-HOzjWNs56AHb6EOoy-aovG6h3brhjhuXdL7GZ7eXKxvv8Mp-7CBY-wn3_rgoOknB33YeuPHDE3B4SbFpyI6tND42Pl-gF1Mgx59DNDMcF0mvtXwIU3Z-c_gqNN9dl9edQXufv64XV9WV9e_fq8vripLGzJWjtUCYy4RpZLTVtcNs5wzK6nrmLXOIsEoFxQLYequaQl1lgosjcCm5o2hK3B68N2n-Di5PKrBZ-v6XgcXp6ywFJIJKYvHCnz7D93FKYXyXaEkaSRjghQKH6gSV87JdWqf_KDTrDBSL_WoQz2qpK5e6lFz2Tl5dZ7M4Np_G3_7KAA5ALmMwsalN6ffdX0Gha6b1A</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>da Silva, Bruna Graziele Marques</creator><creator>Carvalho, Moisés Lopes</creator><creator>Rosseti, Isabela Bueno</creator><creator>Zamuner, Stella</creator><creator>Costa, Maricilia Silva</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7SP</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180701</creationdate><title>Photodynamic antimicrobial chemotherapy (PACT) using toluidine blue inhibits both growth and biofilm formation by Candida krusei</title><author>da Silva, Bruna Graziele Marques ; Carvalho, Moisés Lopes ; Rosseti, Isabela Bueno ; Zamuner, Stella ; Costa, Maricilia Silva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-e5481169033963da475c665c93ef5ccec0853683188b4f7d23ec3819b81b467b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anti-Bacterial Agents - 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Academic</collection><jtitle>Lasers in medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Silva, Bruna Graziele Marques</au><au>Carvalho, Moisés Lopes</au><au>Rosseti, Isabela Bueno</au><au>Zamuner, Stella</au><au>Costa, Maricilia Silva</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photodynamic antimicrobial chemotherapy (PACT) using toluidine blue inhibits both growth and biofilm formation by Candida krusei</atitle><jtitle>Lasers in medical science</jtitle><stitle>Lasers Med Sci</stitle><addtitle>Lasers Med Sci</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>33</volume><issue>5</issue><spage>983</spage><epage>990</epage><pages>983-990</pages><issn>0268-8921</issn><eissn>1435-604X</eissn><abstract>Among non-albicans Candida species, the opportunistic pathogen
Candida krusei
emerges because of the high mortality related to infections produced by this yeast. The
Candida krusei
is an opportunistic pathogen presenting an intrinsic resistance to fluconazol. In spite of the reduced number of infections produced by
C. krusei
, its occurrence is increasing in some groups of patients submitted to the use of fluconazol for prophylaxis. Photodynamic antimicrobial chemotherapy (PACT) is a potential antimicrobial therapy that combines visible light and a nontoxic dye, known as a photosensitizer, producing reactive oxygen species (ROS) that can kill the treated cells. The objective of this study was to investigate the effects of PACT, using toluidine blue, as a photosensitizer on both growth and biofilm formation by
Candida krusei
. In this work, we studied the effect of the PACT, using TB on both cell growth and biofilm formation by
C. krusei
. PACT was performed using a light source with output power of 0.068 W and peak wavelength of 630 nm, resulting in a fluence of 20, 30, or 40 J/cm
2
. In addition, ROS production was determined after PACT. The number of samples used in this study varied from 6 to 8. Statistical differences were evaluated by analysis of variance (ANOVA) and post hoc comparison with Tukey-Kramer test. PACT inhibited both growth and biofilm formation by
C. krusei
. It was also observed that PACT stimulated ROS production. Comparing to cells not irradiated, irradiation was able to increase ROS production in 11.43, 6.27, and 4.37 times, in the presence of TB 0.01, 0.02, and 0.05 mg/mL, respectively. These results suggest that the inhibition observed in the cell growth after PACT could be related to the ROS production, promoting cellular damage. Taken together, these results demonstrated the ability of PACT reducing both cell growth and biofilm formation by
C. krusei
.</abstract><cop>London</cop><pub>Springer London</pub><pmid>29332258</pmid><doi>10.1007/s10103-017-2428-y</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Lasers in medical science, 2018-07, Vol.33 (5), p.983-990 |
| issn | 0268-8921 1435-604X |
| language | eng |
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| subjects | Anti-Bacterial Agents - pharmacology Anti-Infective Agents - pharmacology Antiinfectives and antibacterials Antimicrobial agents Biofilms Biofilms - drug effects Biofilms - growth & development Candida - drug effects Candida - growth & development Candida - physiology Candida krusei Cell growth Cellular manufacture Chemotherapy Dentistry Irradiation Lasers Light Light sources Medicine Medicine & Public Health Microbial Sensitivity Tests Opportunist infection Optical Devices Optics Original Article Pathogens Photochemotherapy Photonics Photosensitizing Agents - pharmacology Prophylaxis Quantum Optics Radiation Reactive oxygen species Reactive Oxygen Species - metabolism Statistical analysis Statistical methods Tolonium Chloride - pharmacology Toluidine Toluidine blue Variance analysis Yeast |
| title | Photodynamic antimicrobial chemotherapy (PACT) using toluidine blue inhibits both growth and biofilm formation by Candida krusei |
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