Amelogenin X impacts age-dependent increase of frequency and number in labial incisor grooves in C57BL/6

Amelogenin X impacts age-dependent increase of frequency and number in labial incisor grooves in C57BL/6

Labial grooves in maxillary incisors have been reported in several wild-type rodent species. Previous studies have reported age-dependent labial grooves occur in moderate prevalence in C57BL/6 mice; however, very little is known about the occurrence of such grooves. In the present study, we observed...

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Veröffentlicht in:Biochemical and biophysical research communications 2018-02, Vol.496 (2), p.324-327
Hauptverfasser: Ota, Masato S., Kondo, Kaori, Li, Yong, Iseki, Sachiko, Yamashita, Atsuko, Gibson, Carolyn W., Kondo, Takashi
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Amelogenin X
Genome-wide screening
Maxillary incisor lesion
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container_end_page 327
container_issue 2
container_start_page 324
container_title Biochemical and biophysical research communications
container_volume 496
creator Ota, Masato S.
Kondo, Kaori
Li, Yong
Iseki, Sachiko
Yamashita, Atsuko
Gibson, Carolyn W.
Kondo, Takashi
description Labial grooves in maxillary incisors have been reported in several wild-type rodent species. Previous studies have reported age-dependent labial grooves occur in moderate prevalence in C57BL/6 mice; however, very little is known about the occurrence of such grooves. In the present study, we observed age-dependent groove formation in C57BL/6 mice up to 26 months after birth and found that not only the frequency of the appearance of incisor grooves but also the number of grooves increased in an age-dependent manner. We examined the molecular mechanisms of age-dependent groove formation by performing DNA microarray analysis of the incisors of 12-month-old (12M) and 24-month-old (24M) mice. Amelx, encoding the major enamel matrix protein AMELOGENIN, was identified as a 12M-specific gene. Comparing with wild-type mice, the maxillary incisors of Amelx−/− mutants indicated the increase of the frequency and number of labial grooves. These findings suggested that the Amelx gene impacts the age-dependent appearance of the labial incisor groove in C57BL/6 mice. •Age-dependent groove formation was observed in C57BL/6 mice.•Both the number and frequency of the grooves were dependent on age.•AMELX gene is associated with these age-dependent grooves in C57BL/6 mice.
doi_str_mv 10.1016/j.bbrc.2018.01.073
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subjects Amelogenin X
Genome-wide screening
Maxillary incisor lesion
title Amelogenin X impacts age-dependent increase of frequency and number in labial incisor grooves in C57BL/6
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