In vitro oral epithelium cytotoxicity and in vivo inflammatory inducing effects of anesthetic rice gel

In vitro cytotoxicity of lidocaine hydrochloride (LH) and prilocaine hydrochloride (PH) to oral epithelial cells, isolated from tissue specimens of healthy volunteers, were evaluated. Cell vitality after treating with 1-20% anesthetic solutions for 5 and 30 min was investigated using F-actin and 4&#...

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Veröffentlicht in:	Drug Discoveries & Therapeutics 2017/12/31, Vol.11(6), pp.323-328
Hauptverfasser:	Khongkhunthian, Sakornrat, Supanchart, Chayarop, Yotsawimonwat, Songwut, Okonogi, Siriporn
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anesthetics, Local - pharmacology Cell Survival - drug effects Cells, Cultured epithelial cell Epithelial Cells - drug effects Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - pathology Gels Gingival Crevicular Fluid - drug effects Gingival Crevicular Fluid - immunology gingival tissue Healthy Volunteers Humans In Vitro Techniques Inflammation - immunology L-Lactate Dehydrogenase - metabolism lidocaine Lidocaine - pharmacology Local anesthetic gel Microscopy, Fluorescence Middle Aged Mouth Mucosa - drug effects Mouth Mucosa - immunology Mouth Mucosa - metabolism Mouth Mucosa - pathology Oryza prilocaine Prilocaine - pharmacology Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - immunology Young Adult
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