Synthesis of Histidine‐Containing Oligopeptides via Histidine‐Promoted Peptide Ligation

Histidine‐containing peptides are valuable therapeutic agents for a treatment of neurodegenerative diseases. However, the synthesis of histidine‐containing peptides is not trivial due to the potential of imidazole sidechain of histidine to act as a nucleophile if unprotected. A peptide ligation meth...

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Veröffentlicht in:	Chemistry, an Asian journal an Asian journal, 2018-02, Vol.13 (4), p.400-403
Hauptverfasser:	Huang, Kai‐Jin, Huang, Yi‐Chen, Lin, Yuya A.
Format:	Artikel
Sprache:	eng
Schlagworte:	acyl transfer Amino acids Chemical compounds chemical ligation Chemistry copper-binding peptides Histidine Imidazole Neurological diseases peptide synthesis Peptides Pharmacology Synthesis Transesterification
Online-Zugang:	Volltext
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