Cigarette smoking, alcohol drinking, and oral cavity and pharyngeal cancer in the Japanese: a population-based cohort study in Japan

The effects of cigarette smoking and alcohol drinking on the incidence of oral cavity and pharyngeal cancer (OCPC) in the Asian population have been poorly understood. To assess the effects of cigarette smoking, alcohol drinking, and facial flushing response on incidence of OCPC, a total of 95 525 m...

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Veröffentlicht in:European journal of cancer prevention 2018-03, Vol.27 (2), p.171-179
Hauptverfasser: Lu, Yuquan, Sobue, Tomotaka, Kitamura, Tetsuhisa, Matsuse, Ryoichi, Kitamura, Yuri, Matsuo, Keitaro, Ito, Hidemi, Oze, Isao, Shimazu, Taichi, Yamaji, Taiki, Iwasaki, Motoki, Sasazuki, Shizuka, Sawada, Norie, Tsugane, Shoichiro
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container_end_page 179
container_issue 2
container_start_page 171
container_title European journal of cancer prevention
container_volume 27
creator Lu, Yuquan
Sobue, Tomotaka
Kitamura, Tetsuhisa
Matsuse, Ryoichi
Kitamura, Yuri
Matsuo, Keitaro
Ito, Hidemi
Oze, Isao
Shimazu, Taichi
Yamaji, Taiki
Iwasaki, Motoki
Sasazuki, Shizuka
Sawada, Norie
Tsugane, Shoichiro
description The effects of cigarette smoking and alcohol drinking on the incidence of oral cavity and pharyngeal cancer (OCPC) in the Asian population have been poorly understood. To assess the effects of cigarette smoking, alcohol drinking, and facial flushing response on incidence of OCPC, a total of 95 525 middle-aged and older eligible individuals were followed in a large-scale population-based cohort study in Japan from 1990 to 2010. In this study, the person-years of observation were 698 006 in men and 846 813 in women, and a total of 222 cases (men=160, women=62) of OCPC were newly diagnosed during the study period. A multivariate Cox proportional-hazards model was used to assess the incidence risk of OCPC and subsites by cigarette smoking and alcohol drinking. The result showed that cigarette smoking and regular alcohol drinking were associated significantly with the incidence of OCPC in men. Compared with nonsmokers and nondrinkers, current male smokers showed a hazard ratio (HR) of 2.37 [95% confidence interval (CI)=1.51-3.70] and regular male drinkers showed an HR of 1.82 (95% CI=1.20-2.76). Cigarette smoking also increased the risk of OCPC among male heavy alcohol drinkers (HR=4.05, 95% CI=2.31-7.11). However, there was no significant association between facial flushing response and OCPC. In conclusion, cigarette smoking and alcohol drinking are independent risk factors for OCPC and its subsites in the male Japanese population.
doi_str_mv 10.1097/cej.0000000000000283
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To assess the effects of cigarette smoking, alcohol drinking, and facial flushing response on incidence of OCPC, a total of 95 525 middle-aged and older eligible individuals were followed in a large-scale population-based cohort study in Japan from 1990 to 2010. In this study, the person-years of observation were 698 006 in men and 846 813 in women, and a total of 222 cases (men=160, women=62) of OCPC were newly diagnosed during the study period. A multivariate Cox proportional-hazards model was used to assess the incidence risk of OCPC and subsites by cigarette smoking and alcohol drinking. The result showed that cigarette smoking and regular alcohol drinking were associated significantly with the incidence of OCPC in men. Compared with nonsmokers and nondrinkers, current male smokers showed a hazard ratio (HR) of 2.37 [95% confidence interval (CI)=1.51-3.70] and regular male drinkers showed an HR of 1.82 (95% CI=1.20-2.76). Cigarette smoking also increased the risk of OCPC among male heavy alcohol drinkers (HR=4.05, 95% CI=2.31-7.11). However, there was no significant association between facial flushing response and OCPC. 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Cigarette smoking also increased the risk of OCPC among male heavy alcohol drinkers (HR=4.05, 95% CI=2.31-7.11). However, there was no significant association between facial flushing response and OCPC. 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Cigarette smoking also increased the risk of OCPC among male heavy alcohol drinkers (HR=4.05, 95% CI=2.31-7.11). However, there was no significant association between facial flushing response and OCPC. In conclusion, cigarette smoking and alcohol drinking are independent risk factors for OCPC and its subsites in the male Japanese population.</abstract><cop>England</cop><pmid>29324519</pmid><doi>10.1097/cej.0000000000000283</doi><tpages>9</tpages></addata></record>
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subjects Adult
Alcohol Drinking - epidemiology
Cigarette Smoking - epidemiology
Face
Female
Flushing - epidemiology
Humans
Incidence
Japan - epidemiology
Male
Middle Aged
Mouth Neoplasms - epidemiology
Mouth Neoplasms - prevention & control
Oropharyngeal Neoplasms - epidemiology
Oropharyngeal Neoplasms - prevention & control
Proportional Hazards Models
Prospective Studies
Risk Assessment
Risk Factors
Sex Factors
title Cigarette smoking, alcohol drinking, and oral cavity and pharyngeal cancer in the Japanese: a population-based cohort study in Japan
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