Protective effects of new antioxidant compositions of 4‐methylcoumarins and related compounds with dl‐α‐tocopherol and l‐ascorbic acid
BACKGROUND Coumarin derivatives possess a wide range of biological activities. By functionalization of the parent coumarin skeleton that has neither antioxidant nor biological activity, a series of new bio‐antioxidants has been designed. RESULTS New antioxidant compositions (equimolar binary and ter...
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| Veröffentlicht in: | Journal of the science of food and agriculture 2018-08, Vol.98 (10), p.3784-3794 |
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| creator | Kancheva, Vessela D Slavova‐Kazakova, Adriana K Angelova, Silvia E Kumar, Prashant Malhotra, Shashwat Singh, Brajendra K Saso, Luciano Prasad, Ashok K Parmar, Virinder S |
| description | BACKGROUND
Coumarin derivatives possess a wide range of biological activities. By functionalization of the parent coumarin skeleton that has neither antioxidant nor biological activity, a series of new bio‐antioxidants has been designed.
RESULTS
New antioxidant compositions (equimolar binary and ternary mixtures) of eight 4‐methylcoumarins and three related compounds have been tested and different effects between individual components have been observed: synergism (positive effect), additivism (summary effect) and antagonism (negative effect). Higher oxidative stability of the lipid substrate was obtained in the presence of the new antioxidant compositions of the studied compounds with dl‐α‐tocopherol and l‐ascorbic acid. The role of each component in the antioxidant compositions of ternary mixtures has been identified by using new equations composed by the authors.
CONCLUSION
All ternary mixtures demonstrate synergism as a result of continuous regeneration of dl‐α‐tocopherol from the studied antioxidants and l‐ascorbic acid. Theoretical calculations have been probed as indicators of the expected effects between the individual components in a binary mixture. © 2018 Society of Chemical Industry |
| doi_str_mv | 10.1002/jsfa.8892 |
| format | Article |
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Coumarin derivatives possess a wide range of biological activities. By functionalization of the parent coumarin skeleton that has neither antioxidant nor biological activity, a series of new bio‐antioxidants has been designed.
RESULTS
New antioxidant compositions (equimolar binary and ternary mixtures) of eight 4‐methylcoumarins and three related compounds have been tested and different effects between individual components have been observed: synergism (positive effect), additivism (summary effect) and antagonism (negative effect). Higher oxidative stability of the lipid substrate was obtained in the presence of the new antioxidant compositions of the studied compounds with dl‐α‐tocopherol and l‐ascorbic acid. The role of each component in the antioxidant compositions of ternary mixtures has been identified by using new equations composed by the authors.
CONCLUSION
All ternary mixtures demonstrate synergism as a result of continuous regeneration of dl‐α‐tocopherol from the studied antioxidants and l‐ascorbic acid. Theoretical calculations have been probed as indicators of the expected effects between the individual components in a binary mixture. © 2018 Society of Chemical Industry</description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.8892</identifier><identifier>PMID: 29344958</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>4‐methylcoumarins ; antioxidant compositions ; Antioxidants ; Ascorbic acid ; Biological activity ; chain‐breaking antioxidant activity ; Composition ; Coumarin ; lipid autoxidation ; Mathematical models ; Organic chemistry ; protective effects ; Regeneration ; Substrates ; Synergism ; Tocopherol ; Vitamin E</subject><ispartof>Journal of the science of food and agriculture, 2018-08, Vol.98 (10), p.3784-3794</ispartof><rights>2018 Society of Chemical Industry</rights><rights>This article is protected by copyright. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2682-ecd5745c2108ebbfb362924e9a1211c4c0968fc495ab595c4f4c28f44869b8ba3</citedby><cites>FETCH-LOGICAL-c2682-ecd5745c2108ebbfb362924e9a1211c4c0968fc495ab595c4f4c28f44869b8ba3</cites><orcidid>0000-0002-4095-5288</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjsfa.8892$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjsfa.8892$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29344958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kancheva, Vessela D</creatorcontrib><creatorcontrib>Slavova‐Kazakova, Adriana K</creatorcontrib><creatorcontrib>Angelova, Silvia E</creatorcontrib><creatorcontrib>Kumar, Prashant</creatorcontrib><creatorcontrib>Malhotra, Shashwat</creatorcontrib><creatorcontrib>Singh, Brajendra K</creatorcontrib><creatorcontrib>Saso, Luciano</creatorcontrib><creatorcontrib>Prasad, Ashok K</creatorcontrib><creatorcontrib>Parmar, Virinder S</creatorcontrib><title>Protective effects of new antioxidant compositions of 4‐methylcoumarins and related compounds with dl‐α‐tocopherol and l‐ascorbic acid</title><title>Journal of the science of food and agriculture</title><addtitle>J Sci Food Agric</addtitle><description>BACKGROUND
Coumarin derivatives possess a wide range of biological activities. By functionalization of the parent coumarin skeleton that has neither antioxidant nor biological activity, a series of new bio‐antioxidants has been designed.
RESULTS
New antioxidant compositions (equimolar binary and ternary mixtures) of eight 4‐methylcoumarins and three related compounds have been tested and different effects between individual components have been observed: synergism (positive effect), additivism (summary effect) and antagonism (negative effect). Higher oxidative stability of the lipid substrate was obtained in the presence of the new antioxidant compositions of the studied compounds with dl‐α‐tocopherol and l‐ascorbic acid. The role of each component in the antioxidant compositions of ternary mixtures has been identified by using new equations composed by the authors.
CONCLUSION
All ternary mixtures demonstrate synergism as a result of continuous regeneration of dl‐α‐tocopherol from the studied antioxidants and l‐ascorbic acid. Theoretical calculations have been probed as indicators of the expected effects between the individual components in a binary mixture. © 2018 Society of Chemical Industry</description><subject>4‐methylcoumarins</subject><subject>antioxidant compositions</subject><subject>Antioxidants</subject><subject>Ascorbic acid</subject><subject>Biological activity</subject><subject>chain‐breaking antioxidant activity</subject><subject>Composition</subject><subject>Coumarin</subject><subject>lipid autoxidation</subject><subject>Mathematical models</subject><subject>Organic chemistry</subject><subject>protective effects</subject><subject>Regeneration</subject><subject>Substrates</subject><subject>Synergism</subject><subject>Tocopherol</subject><subject>Vitamin E</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kUFuEzEUhi0EoqGw4ALIEhtYTGs79sReVhWFokpFAtaW582z4mhmHOwZQna9QbkKF-EQnKROUlhUYuNn_e_TL_v_CXnJ2QlnTJyusncnWhvxiMw4M4uKMc4ek1nZiUpxKY7Is5xXjDFj6vopORJmLqVRekZuP6U4IozhO1L0vtwyjZ4OuKFuGEP8EdoyKcR-HXMowrDfyz83P3scl9sO4tS7FIrshpYm7NyI7YGfhjbTTRiXtO0K__tXOcYIcb3EFLs9v9NdhpiaANRBaJ-TJ951GV_cz2Py9eLdl_MP1dX1-8vzs6sKRK1FhdCqhVQgONPYNL6Z18IIicZxwTlIYKbWHsofXaOMAuklCO2l1LVpdOPmx-TNwXed4rcJ82j7kAG7zg0Yp2y50SUfyZUo6OsH6CpOaSivs4KpEqRUC1aotwcKUsw5obfrFEoyW8uZ3bVkdy3ZXUuFfXXvODU9tv_Iv7UU4PQAbEKH2_872Y-fL872lnfv_qNl</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Kancheva, Vessela D</creator><creator>Slavova‐Kazakova, Adriana K</creator><creator>Angelova, Silvia E</creator><creator>Kumar, Prashant</creator><creator>Malhotra, Shashwat</creator><creator>Singh, Brajendra K</creator><creator>Saso, Luciano</creator><creator>Prasad, Ashok K</creator><creator>Parmar, Virinder S</creator><general>John Wiley & Sons, Ltd</general><general>John Wiley and Sons, Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QL</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4095-5288</orcidid></search><sort><creationdate>20180801</creationdate><title>Protective effects of new antioxidant compositions of 4‐methylcoumarins and related compounds with dl‐α‐tocopherol and l‐ascorbic acid</title><author>Kancheva, Vessela D ; Slavova‐Kazakova, Adriana K ; Angelova, Silvia E ; Kumar, Prashant ; Malhotra, Shashwat ; Singh, Brajendra K ; Saso, Luciano ; Prasad, Ashok K ; Parmar, Virinder S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2682-ecd5745c2108ebbfb362924e9a1211c4c0968fc495ab595c4f4c28f44869b8ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>4‐methylcoumarins</topic><topic>antioxidant compositions</topic><topic>Antioxidants</topic><topic>Ascorbic acid</topic><topic>Biological activity</topic><topic>chain‐breaking antioxidant activity</topic><topic>Composition</topic><topic>Coumarin</topic><topic>lipid autoxidation</topic><topic>Mathematical models</topic><topic>Organic chemistry</topic><topic>protective effects</topic><topic>Regeneration</topic><topic>Substrates</topic><topic>Synergism</topic><topic>Tocopherol</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kancheva, Vessela D</creatorcontrib><creatorcontrib>Slavova‐Kazakova, Adriana K</creatorcontrib><creatorcontrib>Angelova, Silvia E</creatorcontrib><creatorcontrib>Kumar, Prashant</creatorcontrib><creatorcontrib>Malhotra, Shashwat</creatorcontrib><creatorcontrib>Singh, Brajendra K</creatorcontrib><creatorcontrib>Saso, Luciano</creatorcontrib><creatorcontrib>Prasad, Ashok K</creatorcontrib><creatorcontrib>Parmar, Virinder S</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kancheva, Vessela D</au><au>Slavova‐Kazakova, Adriana K</au><au>Angelova, Silvia E</au><au>Kumar, Prashant</au><au>Malhotra, Shashwat</au><au>Singh, Brajendra K</au><au>Saso, Luciano</au><au>Prasad, Ashok K</au><au>Parmar, Virinder S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of new antioxidant compositions of 4‐methylcoumarins and related compounds with dl‐α‐tocopherol and l‐ascorbic acid</atitle><jtitle>Journal of the science of food and agriculture</jtitle><addtitle>J Sci Food Agric</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>98</volume><issue>10</issue><spage>3784</spage><epage>3794</epage><pages>3784-3794</pages><issn>0022-5142</issn><eissn>1097-0010</eissn><abstract>BACKGROUND
Coumarin derivatives possess a wide range of biological activities. By functionalization of the parent coumarin skeleton that has neither antioxidant nor biological activity, a series of new bio‐antioxidants has been designed.
RESULTS
New antioxidant compositions (equimolar binary and ternary mixtures) of eight 4‐methylcoumarins and three related compounds have been tested and different effects between individual components have been observed: synergism (positive effect), additivism (summary effect) and antagonism (negative effect). Higher oxidative stability of the lipid substrate was obtained in the presence of the new antioxidant compositions of the studied compounds with dl‐α‐tocopherol and l‐ascorbic acid. The role of each component in the antioxidant compositions of ternary mixtures has been identified by using new equations composed by the authors.
CONCLUSION
All ternary mixtures demonstrate synergism as a result of continuous regeneration of dl‐α‐tocopherol from the studied antioxidants and l‐ascorbic acid. Theoretical calculations have been probed as indicators of the expected effects between the individual components in a binary mixture. © 2018 Society of Chemical Industry</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>29344958</pmid><doi>10.1002/jsfa.8892</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4095-5288</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | 4‐methylcoumarins antioxidant compositions Antioxidants Ascorbic acid Biological activity chain‐breaking antioxidant activity Composition Coumarin lipid autoxidation Mathematical models Organic chemistry protective effects Regeneration Substrates Synergism Tocopherol Vitamin E |
| title | Protective effects of new antioxidant compositions of 4‐methylcoumarins and related compounds with dl‐α‐tocopherol and l‐ascorbic acid |
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