Nanoparticles with CD44 Targeting and ROS Triggering Properties as Effective in Vivo Antigen Delivery System

Currently, development of subunit vaccine based on recombinant antigens or peptides has gradually become an important alternative option for traditional vaccine. However, induction of potent immune response with desired efficacy remains a major challenge. The nanoparticle-based antigen delivery syst...

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Veröffentlicht in:	Molecular pharmaceutics 2018-02, Vol.15 (2), p.508-518
Hauptverfasser:	Liang, Xiaoyu, Li, Xuanling, Duan, Jianwei, Chen, Youlu, Wang, Xiaoli, Pang, Liyun, Kong, Deling, Song, Bing, Li, Chen, Yang, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens - administration & dosage Antigens - immunology Cell Line Dendritic Cells Drug Delivery Systems - methods Female Hyaluronan Receptors - immunology Hyaluronan Receptors - metabolism Hyaluronic Acid - chemistry Hydrogen Peroxide - chemistry Immunogenicity, Vaccine Mice Mice, Inbred C57BL Nanoparticles - administration & dosage Nanoparticles - chemistry Ovalbumin - administration & dosage Ovalbumin - immunology Polyesters Polyethylene Glycols Reactive Oxygen Species - metabolism T-Lymphocytes - drug effects T-Lymphocytes - immunology Vaccines, Subunit - administration & dosage Vaccines, Subunit - immunology
Online-Zugang:	Volltext
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