Mother-to-child transmission of extended-spectrum-beta-lactamase-producing Enterobacteriaceae
Preterm infants are at high risk for extended-spectrum-beta-lactamase-producing Enterobacteriaceae (ESBL-E) sepsis and neonatal intensive care unit (NICU) outbreaks. Maternal colonization with ESBL-E may be precursory to mother-to-child transmission. However, there is no consensus regarding surveill...
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| Veröffentlicht in: | The Journal of hospital infection 2018-09, Vol.100 (1), p.40-46 |
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| creator | Danino, D. Melamed, R. Sterer, B. Porat, N. Hazan, G. Gushanski, A. Shany, E. Greenberg, D. Borer, A. |
| description | Preterm infants are at high risk for extended-spectrum-beta-lactamase-producing Enterobacteriaceae (ESBL-E) sepsis and neonatal intensive care unit (NICU) outbreaks. Maternal colonization with ESBL-E may be precursory to mother-to-child transmission. However, there is no consensus regarding surveillance of pregnant women for ESBL-E colonization.
To identify pairs of mothers and infants harbouring same-strain ESBL-E colonization and to determine whether maternal transmission may play a role in increasing ESBL-E carriage in preterm infants.
This was a one-year analysis from an ongoing, prospective ESBL-E surveillance of mothers of premature infants and their offspring. Mother–infant pairs colonized with the same bacteria underwent strain analysis using pulsed-field gel electrophoresis (PFGE). Clinical parameters were collected from the hospital computerized records.
Between January 2015 and January 2016, 313/409 (76.5%) mothers and all 478 (100%) infants were screened for ESBL-E colonization; carriage rates were 21.5% and 14.8%, respectively. Four (5.6%) colonized infants developed late-onset sepsis and two (2.8%) died. Twenty-five mother–infant pairs colonized with the same bacterial strain were identified; a subgroup of 10 pairs of isolates underwent PFGE, and 70% displayed an identical PFGE fingerprint. No similarities were found between isolates recovered from unrelated neonates and mothers. ESBL-E colonization was found significantly earlier in infants of mothers colonized at birth (P |
| doi_str_mv | 10.1016/j.jhin.2017.12.024 |
| format | Article |
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To identify pairs of mothers and infants harbouring same-strain ESBL-E colonization and to determine whether maternal transmission may play a role in increasing ESBL-E carriage in preterm infants.
This was a one-year analysis from an ongoing, prospective ESBL-E surveillance of mothers of premature infants and their offspring. Mother–infant pairs colonized with the same bacteria underwent strain analysis using pulsed-field gel electrophoresis (PFGE). Clinical parameters were collected from the hospital computerized records.
Between January 2015 and January 2016, 313/409 (76.5%) mothers and all 478 (100%) infants were screened for ESBL-E colonization; carriage rates were 21.5% and 14.8%, respectively. Four (5.6%) colonized infants developed late-onset sepsis and two (2.8%) died. Twenty-five mother–infant pairs colonized with the same bacterial strain were identified; a subgroup of 10 pairs of isolates underwent PFGE, and 70% displayed an identical PFGE fingerprint. No similarities were found between isolates recovered from unrelated neonates and mothers. ESBL-E colonization was found significantly earlier in infants of mothers colonized at birth (P<0.001) compared with infants of non-colonized mothers.
ESBL-E carriage rates in mothers and NICU infants with non-negligible maternal–neonatal ESBL-E transmission in the study region indicate that maternal colonization surveillance and/or further infection control interventions should be considered.</description><identifier>ISSN: 0195-6701</identifier><identifier>EISSN: 1532-2939</identifier><identifier>DOI: 10.1016/j.jhin.2017.12.024</identifier><identifier>PMID: 29330015</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Colonization ; ESBL ; Mother-to-child transmission ; Preterm infants</subject><ispartof>The Journal of hospital infection, 2018-09, Vol.100 (1), p.40-46</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-870138937aa471316038df4371b4d9ef2fdf01343193cf23fd8fe285d890b2f83</citedby><cites>FETCH-LOGICAL-c356t-870138937aa471316038df4371b4d9ef2fdf01343193cf23fd8fe285d890b2f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0195670118300367$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29330015$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Danino, D.</creatorcontrib><creatorcontrib>Melamed, R.</creatorcontrib><creatorcontrib>Sterer, B.</creatorcontrib><creatorcontrib>Porat, N.</creatorcontrib><creatorcontrib>Hazan, G.</creatorcontrib><creatorcontrib>Gushanski, A.</creatorcontrib><creatorcontrib>Shany, E.</creatorcontrib><creatorcontrib>Greenberg, D.</creatorcontrib><creatorcontrib>Borer, A.</creatorcontrib><title>Mother-to-child transmission of extended-spectrum-beta-lactamase-producing Enterobacteriaceae</title><title>The Journal of hospital infection</title><addtitle>J Hosp Infect</addtitle><description>Preterm infants are at high risk for extended-spectrum-beta-lactamase-producing Enterobacteriaceae (ESBL-E) sepsis and neonatal intensive care unit (NICU) outbreaks. Maternal colonization with ESBL-E may be precursory to mother-to-child transmission. However, there is no consensus regarding surveillance of pregnant women for ESBL-E colonization.
To identify pairs of mothers and infants harbouring same-strain ESBL-E colonization and to determine whether maternal transmission may play a role in increasing ESBL-E carriage in preterm infants.
This was a one-year analysis from an ongoing, prospective ESBL-E surveillance of mothers of premature infants and their offspring. Mother–infant pairs colonized with the same bacteria underwent strain analysis using pulsed-field gel electrophoresis (PFGE). Clinical parameters were collected from the hospital computerized records.
Between January 2015 and January 2016, 313/409 (76.5%) mothers and all 478 (100%) infants were screened for ESBL-E colonization; carriage rates were 21.5% and 14.8%, respectively. Four (5.6%) colonized infants developed late-onset sepsis and two (2.8%) died. Twenty-five mother–infant pairs colonized with the same bacterial strain were identified; a subgroup of 10 pairs of isolates underwent PFGE, and 70% displayed an identical PFGE fingerprint. No similarities were found between isolates recovered from unrelated neonates and mothers. ESBL-E colonization was found significantly earlier in infants of mothers colonized at birth (P<0.001) compared with infants of non-colonized mothers.
ESBL-E carriage rates in mothers and NICU infants with non-negligible maternal–neonatal ESBL-E transmission in the study region indicate that maternal colonization surveillance and/or further infection control interventions should be considered.</description><subject>Colonization</subject><subject>ESBL</subject><subject>Mother-to-child transmission</subject><subject>Preterm infants</subject><issn>0195-6701</issn><issn>1532-2939</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kMlKBDEQhoMoOi4v4EHm6CVtlt4CXkTcQPGiRwnppOJk6O6MSVr07c0wo0dPBVVf_VR9CJ1SUlBC64tlsVy4sWCENgVlBWHlDprRijPMBBe7aEaoqHDdEHqADmNcEkJyv9pHB3nOCaHVDL09-bSAgJPHeuF6M09BjXFwMTo_zr2dw1eC0YDBcQU6hWnAHSSFe6WTGlQEvAreTNqN7_ObMUHwXZ5AcEqDgmO0Z1Uf4WRbj9Dr7c3L9T1-fL57uL56xJpXdcJtPpG3gjdKlQ3ltCa8NbbkDe1KI8Aya2wmSk4F15Zxa1oLrK1MK0jHbMuP0PkmNx_zMUFMMn-goe_VCH6KkopWVE0tRJNRtkF18DEGsHIV3KDCt6RErrXKpVxrlWutkjKZteals23-1A1g_lZ-PWbgcgNA_vLTQZBROxg1GBeyNmm8-y__B2IQigg</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Danino, D.</creator><creator>Melamed, R.</creator><creator>Sterer, B.</creator><creator>Porat, N.</creator><creator>Hazan, G.</creator><creator>Gushanski, A.</creator><creator>Shany, E.</creator><creator>Greenberg, D.</creator><creator>Borer, A.</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180901</creationdate><title>Mother-to-child transmission of extended-spectrum-beta-lactamase-producing Enterobacteriaceae</title><author>Danino, D. ; Melamed, R. ; Sterer, B. ; Porat, N. ; Hazan, G. ; Gushanski, A. ; Shany, E. ; Greenberg, D. ; Borer, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-870138937aa471316038df4371b4d9ef2fdf01343193cf23fd8fe285d890b2f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Colonization</topic><topic>ESBL</topic><topic>Mother-to-child transmission</topic><topic>Preterm infants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Danino, D.</creatorcontrib><creatorcontrib>Melamed, R.</creatorcontrib><creatorcontrib>Sterer, B.</creatorcontrib><creatorcontrib>Porat, N.</creatorcontrib><creatorcontrib>Hazan, G.</creatorcontrib><creatorcontrib>Gushanski, A.</creatorcontrib><creatorcontrib>Shany, E.</creatorcontrib><creatorcontrib>Greenberg, D.</creatorcontrib><creatorcontrib>Borer, A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of hospital infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Danino, D.</au><au>Melamed, R.</au><au>Sterer, B.</au><au>Porat, N.</au><au>Hazan, G.</au><au>Gushanski, A.</au><au>Shany, E.</au><au>Greenberg, D.</au><au>Borer, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mother-to-child transmission of extended-spectrum-beta-lactamase-producing Enterobacteriaceae</atitle><jtitle>The Journal of hospital infection</jtitle><addtitle>J Hosp Infect</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>100</volume><issue>1</issue><spage>40</spage><epage>46</epage><pages>40-46</pages><issn>0195-6701</issn><eissn>1532-2939</eissn><abstract>Preterm infants are at high risk for extended-spectrum-beta-lactamase-producing Enterobacteriaceae (ESBL-E) sepsis and neonatal intensive care unit (NICU) outbreaks. Maternal colonization with ESBL-E may be precursory to mother-to-child transmission. However, there is no consensus regarding surveillance of pregnant women for ESBL-E colonization.
To identify pairs of mothers and infants harbouring same-strain ESBL-E colonization and to determine whether maternal transmission may play a role in increasing ESBL-E carriage in preterm infants.
This was a one-year analysis from an ongoing, prospective ESBL-E surveillance of mothers of premature infants and their offspring. Mother–infant pairs colonized with the same bacteria underwent strain analysis using pulsed-field gel electrophoresis (PFGE). Clinical parameters were collected from the hospital computerized records.
Between January 2015 and January 2016, 313/409 (76.5%) mothers and all 478 (100%) infants were screened for ESBL-E colonization; carriage rates were 21.5% and 14.8%, respectively. Four (5.6%) colonized infants developed late-onset sepsis and two (2.8%) died. Twenty-five mother–infant pairs colonized with the same bacterial strain were identified; a subgroup of 10 pairs of isolates underwent PFGE, and 70% displayed an identical PFGE fingerprint. No similarities were found between isolates recovered from unrelated neonates and mothers. ESBL-E colonization was found significantly earlier in infants of mothers colonized at birth (P<0.001) compared with infants of non-colonized mothers.
ESBL-E carriage rates in mothers and NICU infants with non-negligible maternal–neonatal ESBL-E transmission in the study region indicate that maternal colonization surveillance and/or further infection control interventions should be considered.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29330015</pmid><doi>10.1016/j.jhin.2017.12.024</doi><tpages>7</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Colonization ESBL Mother-to-child transmission Preterm infants |
| title | Mother-to-child transmission of extended-spectrum-beta-lactamase-producing Enterobacteriaceae |
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