Establishment of practical recellularized liver graft for blood perfusion using primary rat hepatocytes and liver sinusoidal endothelial cells

Tissue decellularization produces a three‐dimensional scaffold that can be used to fabricate functional liver grafts following recellularization. Inappropriate cell distribution and clotting during blood perfusion hinder the practical use of recellularized livers. Here we aimed to establish a seedin...

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Veröffentlicht in:	American journal of transplantation 2018-06, Vol.18 (6), p.1351-1359
Hauptverfasser:	Kojima, H., Yasuchika, K., Fukumitsu, K., Ishii, T., Ogiso, S., Miyauchi, Y., Yamaoka, R., Kawai, T., Katayama, H., Yoshitoshi‐Uebayashi, E. Y., Kita, S., Yasuda, K., Sasaki, N., Komori, J., Uemoto, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models: murine Animals artificial organs/support devices basic (laboratory) research/science Blood Cells, Cultured cellular biology Clotting Endothelial cells Endothelial Cells - cytology Hepatocytes Hepatocytes - cytology Liver Liver - cytology Liver - physiology Liver Transplantation liver transplantation/hepatology Liver transplants Male Parenchyma Perfusion Portal vein Rats Rats, Inbred Lew Rats, Transgenic tissue/organ engineering
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