Environmental Exposure Assessment of Fluoroquinolone Antibacterial Agents from Sewage to Soil
The behavior of fluoroquinolone antibacterial agents (FQs) during mechanical−biological wastewater treatment was studied by mass flow analysis. In addition, the fate of FQs in agricultural soils after sludge application was investigated. Concentrations of FQs in filtered wastewater (raw sewage, prim...
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| Veröffentlicht in: | Environmental science & technology 2003-08, Vol.37 (15), p.3243-3249 |
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| creator | Golet, Eva M Xifra, Irene Siegrist, Hansruedi Alder, Alfredo C Giger, Walter |
| description | The behavior of fluoroquinolone antibacterial agents (FQs) during mechanical−biological wastewater treatment was studied by mass flow analysis. In addition, the fate of FQs in agricultural soils after sludge application was investigated. Concentrations of FQs in filtered wastewater (raw sewage, primary, secondary, and tertiary effluents) were determined using solid-phase extraction with mixed phase cation exchange disk cartridges and reversed-phase liquid chromatography with fluorescence detection. FQs in suspended solids, sewage sludge (raw, excess, and anaerobically digested sludge), and sludge-treated soils were determined as described for the aqueous samples but preceded by accelerated solvent extraction. Wastewater treatment resulted in a reduction of the FQ mass flow of 88−92%, mainly due to sorption on sewage sludge. A sludge-wastewater partition coefficient (log K d ∼ 4) was calculated in the activated sludge reactors with a hydraulic residence time of about 8 h. No significant removal of FQs occurred under methanogenic conditions of the sludge digesters. These results suggest sewage sludge as the main reservoir of FQ residues and outline the importance of sludge management strategies to determine whether most of the human-excreted FQs enter the environment. Field experiments of sludge-application to agricultural land confirmed the long-term persistence of trace amounts of FQs in sludge-treated soils and indicated a limited mobility of FQs into the subsoil. |
| doi_str_mv | 10.1021/es0264448 |
| format | Article |
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In addition, the fate of FQs in agricultural soils after sludge application was investigated. Concentrations of FQs in filtered wastewater (raw sewage, primary, secondary, and tertiary effluents) were determined using solid-phase extraction with mixed phase cation exchange disk cartridges and reversed-phase liquid chromatography with fluorescence detection. FQs in suspended solids, sewage sludge (raw, excess, and anaerobically digested sludge), and sludge-treated soils were determined as described for the aqueous samples but preceded by accelerated solvent extraction. Wastewater treatment resulted in a reduction of the FQ mass flow of 88−92%, mainly due to sorption on sewage sludge. A sludge-wastewater partition coefficient (log K d ∼ 4) was calculated in the activated sludge reactors with a hydraulic residence time of about 8 h. No significant removal of FQs occurred under methanogenic conditions of the sludge digesters. These results suggest sewage sludge as the main reservoir of FQ residues and outline the importance of sludge management strategies to determine whether most of the human-excreted FQs enter the environment. Field experiments of sludge-application to agricultural land confirmed the long-term persistence of trace amounts of FQs in sludge-treated soils and indicated a limited mobility of FQs into the subsoil.</description><identifier>ISSN: 0013-936X</identifier><identifier>EISSN: 1520-5851</identifier><identifier>DOI: 10.1021/es0264448</identifier><identifier>PMID: 12966965</identifier><identifier>CODEN: ESTHAG</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Activated Sludge ; Adsorption ; Agriculture ; Applied sciences ; Biodegradation, Environmental ; Earth sciences ; Earth, ocean, space ; Effluents ; Engineering and environment geology. 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Measurement results ; Pollution, environment geology ; Risk Assessment ; Sewage - chemistry ; Sewage disposal ; Sludge ; Soil and sediments pollution ; Soil Microbiology ; Waste Disposal, Fluid ; Wastewaters ; Water Movements ; Water treatment ; Water treatment and pollution</subject><ispartof>Environmental science & technology, 2003-08, Vol.37 (15), p.3243-3249</ispartof><rights>Copyright © 2003 American Chemical Society</rights><rights>2003 INIST-CNRS</rights><rights>Copyright American Chemical Society Aug 1, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a468t-dd8749ee7cdc0659e72e40366c6f9e10423823c3984bfd8186391d5b9f246a673</citedby><cites>FETCH-LOGICAL-a468t-dd8749ee7cdc0659e72e40366c6f9e10423823c3984bfd8186391d5b9f246a673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/es0264448$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/es0264448$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15043006$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12966965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Golet, Eva M</creatorcontrib><creatorcontrib>Xifra, Irene</creatorcontrib><creatorcontrib>Siegrist, Hansruedi</creatorcontrib><creatorcontrib>Alder, Alfredo C</creatorcontrib><creatorcontrib>Giger, Walter</creatorcontrib><title>Environmental Exposure Assessment of Fluoroquinolone Antibacterial Agents from Sewage to Soil</title><title>Environmental science & technology</title><addtitle>Environ. Sci. Technol</addtitle><description>The behavior of fluoroquinolone antibacterial agents (FQs) during mechanical−biological wastewater treatment was studied by mass flow analysis. In addition, the fate of FQs in agricultural soils after sludge application was investigated. Concentrations of FQs in filtered wastewater (raw sewage, primary, secondary, and tertiary effluents) were determined using solid-phase extraction with mixed phase cation exchange disk cartridges and reversed-phase liquid chromatography with fluorescence detection. FQs in suspended solids, sewage sludge (raw, excess, and anaerobically digested sludge), and sludge-treated soils were determined as described for the aqueous samples but preceded by accelerated solvent extraction. Wastewater treatment resulted in a reduction of the FQ mass flow of 88−92%, mainly due to sorption on sewage sludge. A sludge-wastewater partition coefficient (log K d ∼ 4) was calculated in the activated sludge reactors with a hydraulic residence time of about 8 h. No significant removal of FQs occurred under methanogenic conditions of the sludge digesters. These results suggest sewage sludge as the main reservoir of FQ residues and outline the importance of sludge management strategies to determine whether most of the human-excreted FQs enter the environment. Field experiments of sludge-application to agricultural land confirmed the long-term persistence of trace amounts of FQs in sludge-treated soils and indicated a limited mobility of FQs into the subsoil.</description><subject>Activated Sludge</subject><subject>Adsorption</subject><subject>Agriculture</subject><subject>Applied sciences</subject><subject>Biodegradation, Environmental</subject><subject>Earth sciences</subject><subject>Earth, ocean, space</subject><subject>Effluents</subject><subject>Engineering and environment geology. Geothermics</subject><subject>Environmental Exposure</subject><subject>Environmental Monitoring</subject><subject>Exact sciences and technology</subject><subject>fluoroquinolone</subject><subject>Fluoroquinolones - analysis</subject><subject>Fluoroquinolones - metabolism</subject><subject>Fluoroquinolones - toxicity</subject><subject>Models, Theoretical</subject><subject>Other wastewaters</subject><subject>Pharmaceuticals</subject><subject>Pollution</subject><subject>Pollution sources. Measurement results</subject><subject>Pollution, environment geology</subject><subject>Risk Assessment</subject><subject>Sewage - chemistry</subject><subject>Sewage disposal</subject><subject>Sludge</subject><subject>Soil and sediments pollution</subject><subject>Soil Microbiology</subject><subject>Waste Disposal, Fluid</subject><subject>Wastewaters</subject><subject>Water Movements</subject><subject>Water treatment</subject><subject>Water treatment and pollution</subject><issn>0013-936X</issn><issn>1520-5851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0Utv1DAQAGALgehSOPAHUIQEEocUv2Mfl2VLqYp4bJG4IMvrTKqUJF48CZR_X6921ZXgwMmS55vRPAh5yugJo5y9BqRcSynNPTJjitNSGcXukxmlTJRW6G9H5BHiNaWUC2oekiPGrdZWqxn5vhx-tSkOPQyj74rlzSbilKCYIwLi9reITXHaTTHFn1M7xC4OOTqM7dqHEVKbk-ZXmWHRpNgXK_jtr6AYY7GKbfeYPGh8h_Bk_x6Tr6fLy8VZefHx3fvF_KL0UpuxrGtTSQtQhTpQrSxUHCQVWgfdWGBUcmG4CMIauW5qw4wWltVqbRsutdeVOCYvd3U32y4BR9e3GKDr_ABxQsessapi5v9Qai2E4hk-_wtexykNeQiXd8i4kMpm9GqHQoqICRq3SW3v0x_HqNtext1dJttn-4LTuof6IPenyODFHngMvmuSH0KLB6eoFJTq7Mqda3GEm7u4Tz9c3kSl3OWnlVt9WXw4f_NWuM-Huj7gYYh_G7wFvOOvtw</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Golet, Eva M</creator><creator>Xifra, Irene</creator><creator>Siegrist, Hansruedi</creator><creator>Alder, Alfredo C</creator><creator>Giger, Walter</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope><scope>7QH</scope><scope>7QL</scope><scope>7TV</scope><scope>7UA</scope></search><sort><creationdate>20030801</creationdate><title>Environmental Exposure Assessment of Fluoroquinolone Antibacterial Agents from Sewage to Soil</title><author>Golet, Eva M ; Xifra, Irene ; Siegrist, Hansruedi ; Alder, Alfredo C ; Giger, Walter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a468t-dd8749ee7cdc0659e72e40366c6f9e10423823c3984bfd8186391d5b9f246a673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Activated Sludge</topic><topic>Adsorption</topic><topic>Agriculture</topic><topic>Applied sciences</topic><topic>Biodegradation, Environmental</topic><topic>Earth sciences</topic><topic>Earth, ocean, space</topic><topic>Effluents</topic><topic>Engineering and environment geology. Geothermics</topic><topic>Environmental Exposure</topic><topic>Environmental Monitoring</topic><topic>Exact sciences and technology</topic><topic>fluoroquinolone</topic><topic>Fluoroquinolones - analysis</topic><topic>Fluoroquinolones - metabolism</topic><topic>Fluoroquinolones - toxicity</topic><topic>Models, Theoretical</topic><topic>Other wastewaters</topic><topic>Pharmaceuticals</topic><topic>Pollution</topic><topic>Pollution sources. Measurement results</topic><topic>Pollution, environment geology</topic><topic>Risk Assessment</topic><topic>Sewage - chemistry</topic><topic>Sewage disposal</topic><topic>Sludge</topic><topic>Soil and sediments pollution</topic><topic>Soil Microbiology</topic><topic>Waste Disposal, Fluid</topic><topic>Wastewaters</topic><topic>Water Movements</topic><topic>Water treatment</topic><topic>Water treatment and pollution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Golet, Eva M</creatorcontrib><creatorcontrib>Xifra, Irene</creatorcontrib><creatorcontrib>Siegrist, Hansruedi</creatorcontrib><creatorcontrib>Alder, Alfredo C</creatorcontrib><creatorcontrib>Giger, Walter</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>Aqualine</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Pollution Abstracts</collection><collection>Water Resources Abstracts</collection><jtitle>Environmental science & technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Golet, Eva M</au><au>Xifra, Irene</au><au>Siegrist, Hansruedi</au><au>Alder, Alfredo C</au><au>Giger, Walter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental Exposure Assessment of Fluoroquinolone Antibacterial Agents from Sewage to Soil</atitle><jtitle>Environmental science & technology</jtitle><addtitle>Environ. Sci. Technol</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>37</volume><issue>15</issue><spage>3243</spage><epage>3249</epage><pages>3243-3249</pages><issn>0013-936X</issn><eissn>1520-5851</eissn><coden>ESTHAG</coden><abstract>The behavior of fluoroquinolone antibacterial agents (FQs) during mechanical−biological wastewater treatment was studied by mass flow analysis. In addition, the fate of FQs in agricultural soils after sludge application was investigated. Concentrations of FQs in filtered wastewater (raw sewage, primary, secondary, and tertiary effluents) were determined using solid-phase extraction with mixed phase cation exchange disk cartridges and reversed-phase liquid chromatography with fluorescence detection. FQs in suspended solids, sewage sludge (raw, excess, and anaerobically digested sludge), and sludge-treated soils were determined as described for the aqueous samples but preceded by accelerated solvent extraction. Wastewater treatment resulted in a reduction of the FQ mass flow of 88−92%, mainly due to sorption on sewage sludge. A sludge-wastewater partition coefficient (log K d ∼ 4) was calculated in the activated sludge reactors with a hydraulic residence time of about 8 h. No significant removal of FQs occurred under methanogenic conditions of the sludge digesters. These results suggest sewage sludge as the main reservoir of FQ residues and outline the importance of sludge management strategies to determine whether most of the human-excreted FQs enter the environment. Field experiments of sludge-application to agricultural land confirmed the long-term persistence of trace amounts of FQs in sludge-treated soils and indicated a limited mobility of FQs into the subsoil.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>12966965</pmid><doi>10.1021/es0264448</doi><tpages>7</tpages></addata></record> |
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| subjects | Activated Sludge Adsorption Agriculture Applied sciences Biodegradation, Environmental Earth sciences Earth, ocean, space Effluents Engineering and environment geology. Geothermics Environmental Exposure Environmental Monitoring Exact sciences and technology fluoroquinolone Fluoroquinolones - analysis Fluoroquinolones - metabolism Fluoroquinolones - toxicity Models, Theoretical Other wastewaters Pharmaceuticals Pollution Pollution sources. Measurement results Pollution, environment geology Risk Assessment Sewage - chemistry Sewage disposal Sludge Soil and sediments pollution Soil Microbiology Waste Disposal, Fluid Wastewaters Water Movements Water treatment Water treatment and pollution |
| title | Environmental Exposure Assessment of Fluoroquinolone Antibacterial Agents from Sewage to Soil |
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