Selective, Ambient-Temperature C‑4 Deuteration of Pyrazole Derivatives by D2O

A simple, inexpensive, and highly efficient procedure for the selective deuteration (up to >99% D atom %) of the C-4 position of pyrazole substrates activated by NH2 or OH groups at the C-3(5) position is reported. The deuteration reaction is carried out by simply dissolving the substrate in D2O...

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Veröffentlicht in:	Journal of organic chemistry 2018-02, Vol.83 (3), p.1649-1653
Hauptverfasser:	Ahmed, Basil M, Mezei, Gellert
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container_title	Journal of organic chemistry
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creator	Ahmed, Basil M Mezei, Gellert
description	A simple, inexpensive, and highly efficient procedure for the selective deuteration (up to >99% D atom %) of the C-4 position of pyrazole substrates activated by NH2 or OH groups at the C-3(5) position is reported. The deuteration reaction is carried out by simply dissolving the substrate in D2O or other deuterated protic solvents, either in the absence of a catalyst with heating, or under acidic catalysis at ambient temperature; the products are obtained by simple evaporation of the solvent.
doi_str_mv	10.1021/acs.joc.7b03062
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title	Selective, Ambient-Temperature C‑4 Deuteration of Pyrazole Derivatives by D2O
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