Regulators of spindle microtubules and their mechanisms: Living together matters
Development and survival of all eukaryotic organisms depend on equal partitioning of their chromosomes between the two newly formed daughter cells during mitosis. The mitotic spindle performs the task of physically segregating the chromosomes through multiple stages of mitosis. During this process,...
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| Veröffentlicht in: | IUBMB life 2018-02, Vol.70 (2), p.101-111 |
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| creator | Lakshmi, R. Bhagya Nair, Vishnu M. Manna, Tapas K. |
| description | Development and survival of all eukaryotic organisms depend on equal partitioning of their chromosomes between the two newly formed daughter cells during mitosis. The mitotic spindle performs the task of physically segregating the chromosomes through multiple stages of mitosis. During this process, kinetochore‐microtubule attachment requires to be selectively stabilized to hold the chromosomes, but at the same time, it has to be flexible enough to allow kinetochore microtubule dynamicity and chromosome movements. Research during the last decade or so has identified a number of proteins associated with the spindle microtubule plus ends that regulate these processes and orchestrate forces to spatially organize and separate the chromosomes. In this review, we describe the molecular details of those regulators and their mechanisms of action at the kinetochore‐microtubule interface. © 2018 IUBMB Life, 70(2):101–111, 2018 |
| doi_str_mv | 10.1002/iub.1708 |
| format | Article |
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| subjects | Adenomatous Polyposis Coli Protein - genetics Adenomatous Polyposis Coli Protein - metabolism Animals chromosome Chromosome Segregation Chromosomes Humans kinetochore Kinetochores - metabolism microtubule Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Microtubules Microtubules - metabolism Mitosis Neoplasm Proteins - genetics Neoplasm Proteins - metabolism spindle Spindle Apparatus - physiology tubulin |
| title | Regulators of spindle microtubules and their mechanisms: Living together matters |
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