Two three-strand intermediates are processed during Rad51-driven DNA strand exchange

During homologous recombination, Rad51 forms a nucleoprotein filament with single-stranded DNA (ssDNA) that undergoes strand exchange with homologous double-stranded DNA (dsDNA). Here, we use real-time analysis to show that strand exchange by fission yeast Rad51 proceeds via two distinct three-stran...

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Veröffentlicht in:	Nature structural & molecular biology 2018-01, Vol.25 (1), p.29-36
Hauptverfasser:	Ito, Kentaro, Murayama, Yasuto, Takahashi, Masayuki, Iwasaki, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/149 631/45/173 Adenosine Triphosphate - chemistry ATP Biochemistry Biological Microscopy Biological research Biomedical and Life Sciences Biotechnology Calcium Calcium - chemistry Calcium ions Computer Simulation Deoxyribonucleic acid DNA DNA Damage DNA, Fungal - chemistry DNA, Single-Stranded Exchanging Fluorometry Genetic aspects Genetic recombination Genetic research Homologous Recombination Homology Hydrolysis Intermediates Ions Kinetics Life Sciences Membrane Biology Nucleic acids Nucleoproteins - chemistry Physiological aspects Protein Binding Protein Domains Protein Structure Rad51 Recombinase - chemistry Recombinases Regression Analysis Schizosaccharomyces - chemistry Schizosaccharomyces pombe Proteins - chemistry Schizosaccharomyces pombe Proteins - metabolism Single-stranded DNA Yeast Yeasts
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