MicroRNA‐193b‐3p regulates matrix metalloproteinase 19 expression in interleukin‐1β‐induced human chondrocytes

Micro(mi)RNAs are small, non‐coding RNA molecules known to play a significant role in osteoarthritis (OA) initiation and development, and similar to matrix metalloproteinases (MMPs), they participate in cartilage degeneration and cleave multiple extracellular matrices. The aim of this study was to d...

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Veröffentlicht in:	Journal of cellular biochemistry 2018-06, Vol.119 (6), p.4775-4782
Hauptverfasser:	Chang, Zong‐kun, Meng, Fan‐gang, Zhang, Zhi‐qi, Mao, Gu‐ping, Huang, Zhi‐yu, Liao, Wei‐ming, He, Ai‐shan
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Addition polymerization Antisense RNA Arthritis Binding sites Biocompatibility Biomedical materials Cartilage Cartilage diseases Chondrocytes Cytokines Degeneration Gene expression IL-1β Immunohistochemistry Inflammation Inflammatory response Inhibitors Interleukins Matrix metalloproteinase Matrix metalloproteinases Metalloproteinase miRNA miR‐193b‐3p MMP‐19 mRNA Nitric-oxide synthase Osteoarthritis Polymerase chain reaction Ribonucleic acid RNA Test systems Transfection Western blotting
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