DNA vaccine encoding myristoylated membrane protein (MMP) of rock bream iridovirus (RBIV) induces protective immunity in rock bream (Oplegnathus fasciatus)

•Injection of ORF008L (myristoylated membrane protein, MMP) vaccine offered high protection.•TLR3, MyD88, Mx, ISG15, PKR, MHC class I, Fas, Fas ligand, caspase9 and 3 expressed high in vaccine group.•The inflammatory cytokines (IL1β, IL8 and TNFα) were not enhanced in the ORF008L vaccinated group. R...

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Veröffentlicht in:	Vaccine 2018-02, Vol.36 (6), p.802-810
Hauptverfasser:	Jung, Myung-Hwa, Nikapitiya, Chamilani, Jung, Sung-Ju
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Apoptosis Bream Capsid protein Deoxyribonucleic acid Disease DNA DNA vaccine DNA vaccines FasL protein Fish Fish diseases Gangrene Gene expression Genomes Immune response Immune responses Immunity Infections Major capsid protein Major histocompatibility complex Membrane proteins Membranes Mortality Muscles MyD88 protein Myristoylated membrane protein Oplegnathus fasciatus Pagrus major Paralichthys olivaceus Plasmids Protection Proteins Rock bream Rock bream iridovirus Rocks Spleen Survival TLR3 protein Toll-like receptors Vaccination Vaccines Virology Viruses
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