Relationship between Hedgehog Signaling Pathway and Drug Resistance of Poorly Differentiated Gliomas

The effects of Hedgehog signaling inhibitor (cyclopamine) and activator (Shh) on drug resistance of U251-MG human glioma cells and human astrocyte culture to cisplatin, temozolomide, and doxorubicin were studied. Cyclopamine and Shh modified the drug resistance of U251-MG cells but not of human astr...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2018, Vol.164 (3), p.356-361
Hauptverfasser:	Cherepanov, S. A., Grinenko, N. F., Antonova, O. M., Kurapov, P. B., Shepeleva, I. I., Chekhonin, V. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracyclines Astrocytes Biomedical and Life Sciences Biomedicine Cell Biology Cell culture Chemotherapy Cisplatin Doxorubicin Drug resistance Drug therapy Glioma Glioma cells Gliomas Hedgehog protein Internal Medicine Laboratory Medicine Pathology Signal transduction Temozolomide
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