Hyperuricemia enhances intracellular urate accumulation via down-regulation of cell-surface BCRP/ABCG2 expression in vascular endothelial cells

Hyperuricemia has been recognized as an independent risk factor for cardiovascular disease. Urate stimulates NADPH oxidase and induces production of reactive oxygen species (ROS); consequently, intracellular urate accumulation can induce oxidative stress leading to endothelial dysfunction. Here, we...

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Veröffentlicht in:	Biochimica et biophysica acta. Biomembranes 2018-05, Vol.1860 (5), p.973-980
Hauptverfasser:	Komori, Hisakazu, Yamada, Kazuyuki, Tamai, Ikumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Antioxidants - pharmacology ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism BCRP/ABCG2 Cell Membrane - metabolism Cells, Cultured Down-Regulation - genetics Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - physiology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Hyperuricemia - genetics Hyperuricemia - metabolism Intracellular Space - metabolism Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Trafficking Uric acid Uric Acid - metabolism Vascular endothelial cell
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