A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma

To the Editor: Previously, we identified the HLA region as a risk factor for peanut allergy (PA); this observation is supported further by 2 independent genome-wide association studies (GWASs).1,2 The HLA class II genes (including HLA-DR, HLA-DQ, and HLA-DP) encode molecules involved in presentation...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2018-04, Vol.141 (4), p.1513-1516
Hauptverfasser:	Asai, Yuka, Eslami, Aida, van Ginkel, C. Dorien, Akhabir, Loubna, Wan, Ming, Yin, David, Ellis, George, Ben-Shoshan, Moshe, Marenholz, Ingo, Martino, David, Ferreira, Manuel A., Allen, Katrina, Mazer, Bruce, de Groot, Hans, de Jong, Nicolette W., Gerth van Wijk, Roy, Dubois, Anthony E.J., Grosche, Sarah, Ashley, Sarah, Rüschendorf, Franz, Kalb, Birgit, Beyer, Kirsten, Nöthen, Markus M., Lee, Young-Ae, Chin, Rick, Cheuk, Stephen, Hoffman, Joshua, Jorgensen, Eric, Witte, John S., Melles, Ronald B., Hong, Xiumei, Wang, Xiaobin, Hui, Jennie, Musk, Arthur W. (Bill), Hunter, Michael, James, Alan L., Koppelman, Gerard H., Sandford, Andrew J., Clarke, Ann E., Daley, Denise
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Allergies Arachis - immunology Asthma Asthma - genetics Asthma - immunology Canada Child Child, Preschool Comorbidity Female Food allergies Gene expression Genetic Predisposition to Disease - genetics Genome-wide association studies Genome-Wide Association Study - methods Genomes Histocompatibility antigen HLA HLA Antigens - genetics Humans Infant Male Meta-analysis Middle Aged Peanut Hypersensitivity - genetics Peanut Hypersensitivity - immunology Polymorphism, Single Nucleotide - genetics Quality control Risk Factors Studies Young Adult
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