Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study
Dysbiotic gut microbiota have been implicated in human disease. Diet-based therapeutic strategies have been used to manipulate the gut microbiota towards a more favourable profile. However, it has been demonstrated that large inter-individual variability exists in gut microbiota response to a dietar...
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| Veröffentlicht in: | British journal of nutrition 2018-01, Vol.119 (2), p.176-189 |
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| creator | Healey, Genelle Murphy, Rinki Butts, Christine Brough, Louise Whelan, Kevin Coad, Jane |
| description | Dysbiotic gut microbiota have been implicated in human disease. Diet-based therapeutic strategies have been used to manipulate the gut microbiota towards a more favourable profile. However, it has been demonstrated that large inter-individual variability exists in gut microbiota response to a dietary intervention. The primary objective of this study was to investigate whether habitually low dietary fibre (LDF) v. high dietary fibre (HDF) intakes influence gut microbiota response to an inulin-type fructan prebiotic. In this randomised, double-blind, placebo-controlled, cross-over study, thirty-four healthy participants were classified as LDF or HDF consumers. Gut microbiota composition (16S rRNA bacterial gene sequencing) and SCFA concentrations were assessed following 3 weeks of daily prebiotic supplementation (Orafti® Synergy 1; 16 g/d) or placebo (Glucidex® 29 Premium; 16 g/d), as well as after 3 weeks of the alternative intervention, following a 3-week washout period. In the LDF group, the prebiotic intervention led to an increase in Bifidobacterium (P=0·001). In the HDF group, the prebiotic intervention led to an increase in Bifidobacterium (P |
| doi_str_mv | 10.1017/S0007114517003440 |
| format | Article |
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Diet-based therapeutic strategies have been used to manipulate the gut microbiota towards a more favourable profile. However, it has been demonstrated that large inter-individual variability exists in gut microbiota response to a dietary intervention. The primary objective of this study was to investigate whether habitually low dietary fibre (LDF) v. high dietary fibre (HDF) intakes influence gut microbiota response to an inulin-type fructan prebiotic. In this randomised, double-blind, placebo-controlled, cross-over study, thirty-four healthy participants were classified as LDF or HDF consumers. Gut microbiota composition (16S rRNA bacterial gene sequencing) and SCFA concentrations were assessed following 3 weeks of daily prebiotic supplementation (Orafti® Synergy 1; 16 g/d) or placebo (Glucidex® 29 Premium; 16 g/d), as well as after 3 weeks of the alternative intervention, following a 3-week washout period. In the LDF group, the prebiotic intervention led to an increase in Bifidobacterium (P=0·001). In the HDF group, the prebiotic intervention led to an increase in Bifidobacterium (P<0·001) and Faecalibacterium (P=0·010) and decreases in Coprococcus (P=0·010), Dorea (P=0·043) and Ruminococcus (Lachnospiraceae family) (P=0·032). This study demonstrates that those with HDF intakes have a greater gut microbiota response and are therefore more likely to benefit from an inulin-type fructan prebiotic than those with LDF intakes. Future studies aiming to modulate the gut microbiota and improve host health, using an inulin-type fructan prebiotic, should take habitual dietary fibre intake into account.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114517003440</identifier><identifier>PMID: 29307330</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Alcohol ; Bacteria ; Cynara scolymus ; Diet ; Dietary fiber ; Dietary intake ; Dietary supplements ; Double-blind studies ; Food ; Gene sequencing ; Influence ; Intervention ; Intestinal microflora ; Inulin ; Medical screening ; Microbiology ; Microbiota ; Nutrition research ; Prebiotics ; Randomization ; rRNA 16S</subject><ispartof>British journal of nutrition, 2018-01, Vol.119 (2), p.176-189</ispartof><rights>Copyright © The Authors 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-8f5dd3e201b68d081c047c3e85a15b9fb9dfd7b58182f4f746c6505cb94e40523</citedby><cites>FETCH-LOGICAL-c416t-8f5dd3e201b68d081c047c3e85a15b9fb9dfd7b58182f4f746c6505cb94e40523</cites><orcidid>0000-0003-1418-2856</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114517003440/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27923,27924,55627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29307330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Healey, Genelle</creatorcontrib><creatorcontrib>Murphy, Rinki</creatorcontrib><creatorcontrib>Butts, Christine</creatorcontrib><creatorcontrib>Brough, Louise</creatorcontrib><creatorcontrib>Whelan, Kevin</creatorcontrib><creatorcontrib>Coad, Jane</creatorcontrib><title>Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Dysbiotic gut microbiota have been implicated in human disease. Diet-based therapeutic strategies have been used to manipulate the gut microbiota towards a more favourable profile. However, it has been demonstrated that large inter-individual variability exists in gut microbiota response to a dietary intervention. The primary objective of this study was to investigate whether habitually low dietary fibre (LDF) v. high dietary fibre (HDF) intakes influence gut microbiota response to an inulin-type fructan prebiotic. In this randomised, double-blind, placebo-controlled, cross-over study, thirty-four healthy participants were classified as LDF or HDF consumers. Gut microbiota composition (16S rRNA bacterial gene sequencing) and SCFA concentrations were assessed following 3 weeks of daily prebiotic supplementation (Orafti® Synergy 1; 16 g/d) or placebo (Glucidex® 29 Premium; 16 g/d), as well as after 3 weeks of the alternative intervention, following a 3-week washout period. In the LDF group, the prebiotic intervention led to an increase in Bifidobacterium (P=0·001). In the HDF group, the prebiotic intervention led to an increase in Bifidobacterium (P<0·001) and Faecalibacterium (P=0·010) and decreases in Coprococcus (P=0·010), Dorea (P=0·043) and Ruminococcus (Lachnospiraceae family) (P=0·032). This study demonstrates that those with HDF intakes have a greater gut microbiota response and are therefore more likely to benefit from an inulin-type fructan prebiotic than those with LDF intakes. Future studies aiming to modulate the gut microbiota and improve host health, using an inulin-type fructan prebiotic, should take habitual dietary fibre intake into account.</description><subject>Alcohol</subject><subject>Bacteria</subject><subject>Cynara scolymus</subject><subject>Diet</subject><subject>Dietary fiber</subject><subject>Dietary intake</subject><subject>Dietary supplements</subject><subject>Double-blind studies</subject><subject>Food</subject><subject>Gene sequencing</subject><subject>Influence</subject><subject>Intervention</subject><subject>Intestinal microflora</subject><subject>Inulin</subject><subject>Medical screening</subject><subject>Microbiology</subject><subject>Microbiota</subject><subject>Nutrition research</subject><subject>Prebiotics</subject><subject>Randomization</subject><subject>rRNA 16S</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kctuFTEMhiMEoqeFB2CDIrFh0YFkJpkLO1RBi1SJBbAe5eKUlEwy5FLpvBpPR-b0gBCIleX48__HNkLPKHlFCR1efyKEDJQyTgdCOsbIA7SjbOBN2_ftQ7Tbys1WP0GnKd3WdKRkeoxO2qkjQ9eRHfpxJaTNRTisLWQR99hYGQFbn8W3LRhXwCtI-KZkvFgVg7QhCxwhrcEnwDlg4StYnPVN3q-ATSwq17c1wsZa9QZXXngdFptAn2MdinTQyNpRs9UJBTI0Kvgcg3MbUW1SasIdxHP8tSwHgwzxDny2weOUi94_QY-McAmeHuMZ-vL-3eeLq-b64-WHi7fXjWK0z81ouNYdtITKftR1A4qwQXUwckG5nIyctNGD5CMdW8PMwHrVc8KVnBgwwtvuDL28111j-F4g5bmOocA54SGUNNNpnDifWk4r-uIv9DaU6OvvDtTIx3baBOk9dZgygpnXaJe6-5mSeTvs_M9ha8_zo3KRC-jfHb8uWYHuKCoWGa2-gT-8_yv7E1AnsJE</recordid><startdate>20180128</startdate><enddate>20180128</enddate><creator>Healey, Genelle</creator><creator>Murphy, Rinki</creator><creator>Butts, Christine</creator><creator>Brough, Louise</creator><creator>Whelan, Kevin</creator><creator>Coad, Jane</creator><general>Cambridge University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1418-2856</orcidid></search><sort><creationdate>20180128</creationdate><title>Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study</title><author>Healey, Genelle ; 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Diet-based therapeutic strategies have been used to manipulate the gut microbiota towards a more favourable profile. However, it has been demonstrated that large inter-individual variability exists in gut microbiota response to a dietary intervention. The primary objective of this study was to investigate whether habitually low dietary fibre (LDF) v. high dietary fibre (HDF) intakes influence gut microbiota response to an inulin-type fructan prebiotic. In this randomised, double-blind, placebo-controlled, cross-over study, thirty-four healthy participants were classified as LDF or HDF consumers. Gut microbiota composition (16S rRNA bacterial gene sequencing) and SCFA concentrations were assessed following 3 weeks of daily prebiotic supplementation (Orafti® Synergy 1; 16 g/d) or placebo (Glucidex® 29 Premium; 16 g/d), as well as after 3 weeks of the alternative intervention, following a 3-week washout period. In the LDF group, the prebiotic intervention led to an increase in Bifidobacterium (P=0·001). In the HDF group, the prebiotic intervention led to an increase in Bifidobacterium (P<0·001) and Faecalibacterium (P=0·010) and decreases in Coprococcus (P=0·010), Dorea (P=0·043) and Ruminococcus (Lachnospiraceae family) (P=0·032). This study demonstrates that those with HDF intakes have a greater gut microbiota response and are therefore more likely to benefit from an inulin-type fructan prebiotic than those with LDF intakes. Future studies aiming to modulate the gut microbiota and improve host health, using an inulin-type fructan prebiotic, should take habitual dietary fibre intake into account.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>29307330</pmid><doi>10.1017/S0007114517003440</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-1418-2856</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alcohol Bacteria Cynara scolymus Diet Dietary fiber Dietary intake Dietary supplements Double-blind studies Food Gene sequencing Influence Intervention Intestinal microflora Inulin Medical screening Microbiology Microbiota Nutrition research Prebiotics Randomization rRNA 16S |
| title | Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study |
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