Explore the effects of Huang-Lian-Jie-Du-Tang on Alzheimer’s disease by UPLC-QTOF/MS-based plasma metabolomics study

[Display omitted] •The underlying mechanism of HLJDT was explored by valid UPLC–MS-based metabolomics.•Memory amelioration and reduced neuroinflammation were observed in HLJDT group mice.•Callback of lipid metabolic disorder indicates the effects of HLJDT on APP/PS1 mice. Alzheimer's disease (A...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2018-03, Vol.151, p.75-83
Hauptverfasser:	Sun, Li-Min, Zhu, Bao-Jie, Cao, Hui-Ting, Zhang, Xin-Yi, Zhang, Qi-Chun, Xin, Gui-Zhong, Pan, Lin-Mei, Liu, Li-Fang, Zhu, Hua-Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - blood Alzheimer Disease - drug therapy Alzheimer Disease - genetics Alzheimer’s disease (AD) Animals Anti-neuroinflammation Chromatography, High Pressure Liquid - methods Drugs, Chinese Herbal - metabolism Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Huang-Lian-Jie-Du-Tang (HLJDT) Male Maze Learning - drug effects Maze Learning - physiology Medicine, Chinese Traditional - methods Metabolomics Metabolomics - methods Mice Mice, Transgenic Potential biomarkers Random Allocation Tandem Mass Spectrometry - methods Treatment Outcome
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