Macrophage-Specific in Vivo Gene Editing Using Cationic Lipid-Assisted Polymeric Nanoparticles

The CRISPR/Cas9 gene editing technology holds promise for the treatment of multiple diseases. However, the inability to perform specific gene editing in targeted tissues and cells, which may cause off-target effects, is one of the critical bottlenecks for therapeutic application of CRISPR/Cas9. Here...

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Veröffentlicht in:	ACS nano 2018-02, Vol.12 (2), p.994-1005
Hauptverfasser:	Luo, Ying-Li, Xu, Cong-Fei, Li, Hong-Jun, Cao, Zhi-Ting, Liu, Jing, Wang, Ji-Long, Du, Xiao-Jiao, Yang, Xian-Zhu, Gu, Zhen, Wang, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cations - chemistry Cells, Cultured CRISPR-Cas Systems - genetics Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 2 - chemically induced Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diet, High-Fat Gene Editing HEK293 Cells Humans Lipids - chemistry Macrophages - chemistry Macrophages - metabolism Mice Mice, Inbred C57BL Nanoparticles - chemistry Netrin-1 - genetics Netrin-1 - metabolism Polymers - chemistry RAW 264.7 Cells
Online-Zugang:	Volltext
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