Altered hemoglobin co-factor sensitivity does not underlie the evolution of derived fossorial specializations in the family Talpidae

The high O2 affinity of European mole (Talpa europaea) blood is postulated to largely arise from the presence of two β-globin chain residues (β4 Ser and β5 Gly) that weaken the interaction of its hemoglobin (Hb) with the red cell organophosphate 2,3-diphosphoglycerate (DPG). This latter trait is gen...

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Veröffentlicht in:	Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2018-10, Vol.224, p.150-155
Hauptverfasser:	Campbell, Kevin L., Gaudry, Michael J., He, Kai, Suzuki, Hitoshi, Zhang, Ya-ping, Jiang, Xue-Long, Weber, Roy E.
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3-Diphosphoglycerate Animals Biological Evolution Evolution Hemoglobin Hemoglobins - metabolism Moles - metabolism Oxygen - metabolism Oxygen affinity Species Specificity Talpidae
Online-Zugang:	Volltext
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