The novel brassinosteroid analog BR4848 inhibits angiogenesis in human endothelial cells and induces apoptosis in human cancer cells in vitro

•We synthesized a novel brassinosteroid analog, BR4848.•The developed compound demonstrated a high therapeutic index.•We documented the antiproliferative effects of BR4848 in HeLa cells.•BR4848 showed antiangiogenic effects in endothelial cells.•BR4848 modulated cancer cell proliferation, cell cycle...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2018-04, Vol.178, p.263-271
Hauptverfasser:	Rárová, Lucie, Sedlák, David, Oklestkova, Jana, Steigerová, Jana, Liebl, Johanna, Zahler, Stefan, Bartůněk, Petr, Kolář, Zdeněk, Kohout, Ladislav, Kvasnica, Miroslav, Strnad, Miroslav
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Apoptosis Apoptosis - drug effects Brassinosteroid analog Brassinosteroids - chemistry Brassinosteroids - pharmacology Cancer cell lines Cell Cycle Checkpoints - drug effects Cell Proliferation - drug effects Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - pathology Humans HUVEC In Vitro Techniques Neoplasms - blood supply Neoplasms - drug therapy Neoplasms - pathology Neovascularization, Pathologic - pathology Neovascularization, Pathologic - prevention & control Phosphorylation Signal Transduction Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!