Interneuron synaptopathy in developing rat cortex induced by the pro-inflammatory cytokine LIF

Pro-inflammatory cytokines of the IL-6 family have been linked to the etiology of epilepsy and mental disorders. After infusion of the IL-6 family member leukemia inhibitory factor (LIF) into postnatal day 12–20 rat visual cortex (period of synaptogenesis; equals early childhood in human) and equiva...

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Veröffentlicht in:	Experimental neurology 2018-04, Vol.302, p.169-180
Hauptverfasser:	Engelhardt, Maren, Hamad, Mohammad I.K., Jack, Alexander, Ahmed, Küpra, König, Jennifer, Rennau, Lisa Marie, Jamann, Nora, Räk, Andrea, Schönfelder, Sabine, Riedel, Christian, Wirth, Markus Joseph, Patz, Silke, Wahle, Petra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Axons - drug effects Basket cell Brain-Derived Neurotrophic Factor - pharmacology Calcium - metabolism Dendrites - drug effects In Vitro Techniques Interneurons - cytology Interneurons - drug effects Interneurons - metabolism Leukemia inhibitory factor Leukemia Inhibitory Factor - pharmacology Mitogen-Activated Protein Kinase Kinases - metabolism Neocortex Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neuropeptide Y - genetics Neuropeptide Y - metabolism Organ Culture Techniques Plasticity Rats Rats, Long-Evans Shaw Potassium Channels - genetics Shaw Potassium Channels - metabolism Synapses - drug effects Synaptopathy Synaptotagmin II - genetics Synaptotagmin II - metabolism Time Factors TrkB Visual Cortex - cytology
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