Synergistic Effect of Polyvinyl Alcohol and Copovidone in Itraconazole Amorphous Solid Dispersions

ABSTRACT Purpose The first objective is to evaluate the feasibility of melt-extruding polyvinyl alcohol-based amorphous solid dispersions for oral drug delivery. The second objective is to investigate the miscibility between polyvinyl alcohol 4-88 and copovidone, and to characterize the properties o...

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Veröffentlicht in:	Pharmaceutical research 2018-01, Vol.35 (1), p.16-15, Article 16
Hauptverfasser:	Wlodarski, Kamil, Zhang, Feng, Liu, Tongzhou, Sawicki, Wieslaw, Kipping, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols Analysis Antifungal agents Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Chemical industry Chemical precipitation Dispersions Drug delivery Drug delivery systems Drugs Extrusions Feasibility studies Formulation and Manufacturing of Solid Dosage Forms Inhibition Itraconazole Medical Law pH effects Pharmacology/Toxicology Pharmacy Phosphates Polarity Polymers Polyvinyl alcohol Research Paper Solubility Supersaturation Ternary systems Vehicles Water purification
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