Identification of metabolites of MDR-1339, an inhibitor of β-amyloid protein aggregation, and kinetic characterization of the major metabolites in rats

•Identification of ten metabolites (i.e., 7 Phase 1 + 3 Phase 2) of MDR-1339 in rats.•Proposal for the major metabolic pathways to be CYP3A4, 2B6 and 2C9.•Simultaneous quantification of MDR-1339 and its major metabolite M1 and M2.•Formation of M1 accounted for ∼19.7% of the total MDR-1339 eliminatio...

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