Correlation Between Postoperative Central Corneal Thickness and Endothelial Damage After Cataract Surgery by Phacoemulsification
PURPOSE:To study the correlation between postoperative corneal edema and endothelial cell loss after cataract surgery by microcoaxial phacoemulsification. METHODS:Eighty-five eyes of 85 consecutive patients with mild cataract (up to C5, N4, and P5per LOCS III classification) were included in a prosp...
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| Veröffentlicht in: | Cornea 2018-05, Vol.37 (5), p.587-590 |
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| creator | Perone, Jean Marc Boiche, Mathilde Lhuillier, Louis Ameloot, Francis Premy, Shamour Jeancolas, Anne-Laure Goetz, Christophe Neiter, Estelle |
| description | PURPOSE:To study the correlation between postoperative corneal edema and endothelial cell loss after cataract surgery by microcoaxial phacoemulsification.
METHODS:Eighty-five eyes of 85 consecutive patients with mild cataract (up to C5, N4, and P5per LOCS III classification) were included in a prospective study from September 2014 to November 2014. Eighty-five eyes were necessary to obtain a precision of 0.15 for computation of the Pearson correlation coefficient. Pachymetry and endothelial cell density measurements were taken preoperatively, 2 hours after surgery, and 4 days, 15 days, and 1 month after surgery using CEM-530 noncontact specular microscopy (Nidek CO Ltd, Japan). Every surgery was performed using the Stellaris device (Bausch & Lomb, Bridgewater, NJ) in a microcoaxial mode with 2.2-mm incisions.
RESULTS:Mean age was 73 ± 2.1 years, with 41 women (48%) and 44 men (52%). The mean surgical time was 8 ± 5.5 minutes, and the mean effective phacoemulsification time was 7 ± 3.7 seconds. Mean central corneal thickness augmentation was 46.68 ± 10 μm (8.39%) 2 hours after surgery, 10 ± 18 μm (1.8%) 4 days after surgery, and only 0.76 ± 11.4 μm (0.1%) 15 days after surgery. Mean endothelial cell loss was 3.0 ± 1.5% at 2 hours, 9.0 ± 3.3% at D4, 10 ± 4.6% at D15, and 11 ± 4.7% at 1 month. At D4, significant endothelial loss (>15%) was mostly related to significant immediate corneal edema (>15%), whereas low postoperative edema ( |
| doi_str_mv | 10.1097/ICO.0000000000001502 |
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METHODS:Eighty-five eyes of 85 consecutive patients with mild cataract (up to C5, N4, and P5per LOCS III classification) were included in a prospective study from September 2014 to November 2014. Eighty-five eyes were necessary to obtain a precision of 0.15 for computation of the Pearson correlation coefficient. Pachymetry and endothelial cell density measurements were taken preoperatively, 2 hours after surgery, and 4 days, 15 days, and 1 month after surgery using CEM-530 noncontact specular microscopy (Nidek CO Ltd, Japan). Every surgery was performed using the Stellaris device (Bausch & Lomb, Bridgewater, NJ) in a microcoaxial mode with 2.2-mm incisions.
RESULTS:Mean age was 73 ± 2.1 years, with 41 women (48%) and 44 men (52%). The mean surgical time was 8 ± 5.5 minutes, and the mean effective phacoemulsification time was 7 ± 3.7 seconds. Mean central corneal thickness augmentation was 46.68 ± 10 μm (8.39%) 2 hours after surgery, 10 ± 18 μm (1.8%) 4 days after surgery, and only 0.76 ± 11.4 μm (0.1%) 15 days after surgery. Mean endothelial cell loss was 3.0 ± 1.5% at 2 hours, 9.0 ± 3.3% at D4, 10 ± 4.6% at D15, and 11 ± 4.7% at 1 month. At D4, significant endothelial loss (>15%) was mostly related to significant immediate corneal edema (>15%), whereas low postoperative edema (<5%) did not lead to significant endothelial loss (loss <5%). At D15 and D30, endothelial cell loss seemed to be closely correlated with immediate postoperative edema (Pearson correlation coefficient between central corneal edema at H2 and endothelial cells loss at 1 monthr = 0.4, P < 0.0001).
CONCLUSIONS:Postoperative corneal thickness measurement may therefore become a marker of endothelial damage after phacoemulsification.</description><identifier>ISSN: 0277-3740</identifier><identifier>EISSN: 1536-4798</identifier><identifier>DOI: 10.1097/ICO.0000000000001502</identifier><identifier>PMID: 29303887</identifier><language>eng</language><publisher>United States: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Aged ; Cell Count ; Corneal Edema - pathology ; Corneal Endothelial Cell Loss - pathology ; Corneal Pachymetry ; Female ; Humans ; Male ; Middle Aged ; Phacoemulsification - adverse effects ; Phacoemulsification - methods ; Postoperative Complications - pathology ; Prospective Studies</subject><ispartof>Cornea, 2018-05, Vol.37 (5), p.587-590</ispartof><rights>Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4222-e11184d478bf0633cba721126274e834909781147515bcdab066f5b863cd18d33</citedby><cites>FETCH-LOGICAL-c4222-e11184d478bf0633cba721126274e834909781147515bcdab066f5b863cd18d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29303887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perone, Jean Marc</creatorcontrib><creatorcontrib>Boiche, Mathilde</creatorcontrib><creatorcontrib>Lhuillier, Louis</creatorcontrib><creatorcontrib>Ameloot, Francis</creatorcontrib><creatorcontrib>Premy, Shamour</creatorcontrib><creatorcontrib>Jeancolas, Anne-Laure</creatorcontrib><creatorcontrib>Goetz, Christophe</creatorcontrib><creatorcontrib>Neiter, Estelle</creatorcontrib><title>Correlation Between Postoperative Central Corneal Thickness and Endothelial Damage After Cataract Surgery by Phacoemulsification</title><title>Cornea</title><addtitle>Cornea</addtitle><description>PURPOSE:To study the correlation between postoperative corneal edema and endothelial cell loss after cataract surgery by microcoaxial phacoemulsification.
METHODS:Eighty-five eyes of 85 consecutive patients with mild cataract (up to C5, N4, and P5per LOCS III classification) were included in a prospective study from September 2014 to November 2014. Eighty-five eyes were necessary to obtain a precision of 0.15 for computation of the Pearson correlation coefficient. Pachymetry and endothelial cell density measurements were taken preoperatively, 2 hours after surgery, and 4 days, 15 days, and 1 month after surgery using CEM-530 noncontact specular microscopy (Nidek CO Ltd, Japan). Every surgery was performed using the Stellaris device (Bausch & Lomb, Bridgewater, NJ) in a microcoaxial mode with 2.2-mm incisions.
RESULTS:Mean age was 73 ± 2.1 years, with 41 women (48%) and 44 men (52%). The mean surgical time was 8 ± 5.5 minutes, and the mean effective phacoemulsification time was 7 ± 3.7 seconds. Mean central corneal thickness augmentation was 46.68 ± 10 μm (8.39%) 2 hours after surgery, 10 ± 18 μm (1.8%) 4 days after surgery, and only 0.76 ± 11.4 μm (0.1%) 15 days after surgery. Mean endothelial cell loss was 3.0 ± 1.5% at 2 hours, 9.0 ± 3.3% at D4, 10 ± 4.6% at D15, and 11 ± 4.7% at 1 month. At D4, significant endothelial loss (>15%) was mostly related to significant immediate corneal edema (>15%), whereas low postoperative edema (<5%) did not lead to significant endothelial loss (loss <5%). At D15 and D30, endothelial cell loss seemed to be closely correlated with immediate postoperative edema (Pearson correlation coefficient between central corneal edema at H2 and endothelial cells loss at 1 monthr = 0.4, P < 0.0001).
CONCLUSIONS:Postoperative corneal thickness measurement may therefore become a marker of endothelial damage after phacoemulsification.</description><subject>Aged</subject><subject>Cell Count</subject><subject>Corneal Edema - pathology</subject><subject>Corneal Endothelial Cell Loss - pathology</subject><subject>Corneal Pachymetry</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phacoemulsification - adverse effects</subject><subject>Phacoemulsification - methods</subject><subject>Postoperative Complications - pathology</subject><subject>Prospective Studies</subject><issn>0277-3740</issn><issn>1536-4798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhi3UCpaFf4CQj70E_JXYOUJKAQkJpNJz5DgTEnDixXa62lt_Om4XEOLQuYw088y80oPQESUnlJTy9Lq6PSEfiuaE7aAFzXmRCVmqL2hBmJQZl4Lsof0QHhMkZcF20R4rOeFKyQX6Uznvweo4uAmfQ1wDTPjOhehW4NP0N-AKpui1xYmcIPX7fjBPE4SA9dTii6l1sQc7pM13PeoHwGddBI8rHbXXJuKfs38Av8HNBt_12jgYZxuGbjD_Qg_Q107bAIevfYl-_bi4r66ym9vL6-rsJjOCMZYBpVSJVkjVdKTg3DRaMkpZwaQAxUWZlChKhcxp3phWN6QourxRBTctVS3nS_Rt-3fl3fMMIdbjEAxYqydwc6hpqcqkrkz-lkhsUeNdCB66euWHUftNTUn9132d3Nef3aez49eEuRmhfT96k50AtQXWziZD4cnOa_B1n6TG_v-_XwD605EG</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Perone, Jean Marc</creator><creator>Boiche, Mathilde</creator><creator>Lhuillier, Louis</creator><creator>Ameloot, Francis</creator><creator>Premy, Shamour</creator><creator>Jeancolas, Anne-Laure</creator><creator>Goetz, Christophe</creator><creator>Neiter, Estelle</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201805</creationdate><title>Correlation Between Postoperative Central Corneal Thickness and Endothelial Damage After Cataract Surgery by Phacoemulsification</title><author>Perone, Jean Marc ; Boiche, Mathilde ; Lhuillier, Louis ; Ameloot, Francis ; Premy, Shamour ; Jeancolas, Anne-Laure ; Goetz, Christophe ; Neiter, Estelle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4222-e11184d478bf0633cba721126274e834909781147515bcdab066f5b863cd18d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Cell Count</topic><topic>Corneal Edema - pathology</topic><topic>Corneal Endothelial Cell Loss - pathology</topic><topic>Corneal Pachymetry</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Phacoemulsification - adverse effects</topic><topic>Phacoemulsification - methods</topic><topic>Postoperative Complications - pathology</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perone, Jean Marc</creatorcontrib><creatorcontrib>Boiche, Mathilde</creatorcontrib><creatorcontrib>Lhuillier, Louis</creatorcontrib><creatorcontrib>Ameloot, Francis</creatorcontrib><creatorcontrib>Premy, Shamour</creatorcontrib><creatorcontrib>Jeancolas, Anne-Laure</creatorcontrib><creatorcontrib>Goetz, Christophe</creatorcontrib><creatorcontrib>Neiter, Estelle</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cornea</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perone, Jean Marc</au><au>Boiche, Mathilde</au><au>Lhuillier, Louis</au><au>Ameloot, Francis</au><au>Premy, Shamour</au><au>Jeancolas, Anne-Laure</au><au>Goetz, Christophe</au><au>Neiter, Estelle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation Between Postoperative Central Corneal Thickness and Endothelial Damage After Cataract Surgery by Phacoemulsification</atitle><jtitle>Cornea</jtitle><addtitle>Cornea</addtitle><date>2018-05</date><risdate>2018</risdate><volume>37</volume><issue>5</issue><spage>587</spage><epage>590</epage><pages>587-590</pages><issn>0277-3740</issn><eissn>1536-4798</eissn><abstract>PURPOSE:To study the correlation between postoperative corneal edema and endothelial cell loss after cataract surgery by microcoaxial phacoemulsification.
METHODS:Eighty-five eyes of 85 consecutive patients with mild cataract (up to C5, N4, and P5per LOCS III classification) were included in a prospective study from September 2014 to November 2014. Eighty-five eyes were necessary to obtain a precision of 0.15 for computation of the Pearson correlation coefficient. Pachymetry and endothelial cell density measurements were taken preoperatively, 2 hours after surgery, and 4 days, 15 days, and 1 month after surgery using CEM-530 noncontact specular microscopy (Nidek CO Ltd, Japan). Every surgery was performed using the Stellaris device (Bausch & Lomb, Bridgewater, NJ) in a microcoaxial mode with 2.2-mm incisions.
RESULTS:Mean age was 73 ± 2.1 years, with 41 women (48%) and 44 men (52%). The mean surgical time was 8 ± 5.5 minutes, and the mean effective phacoemulsification time was 7 ± 3.7 seconds. Mean central corneal thickness augmentation was 46.68 ± 10 μm (8.39%) 2 hours after surgery, 10 ± 18 μm (1.8%) 4 days after surgery, and only 0.76 ± 11.4 μm (0.1%) 15 days after surgery. Mean endothelial cell loss was 3.0 ± 1.5% at 2 hours, 9.0 ± 3.3% at D4, 10 ± 4.6% at D15, and 11 ± 4.7% at 1 month. At D4, significant endothelial loss (>15%) was mostly related to significant immediate corneal edema (>15%), whereas low postoperative edema (<5%) did not lead to significant endothelial loss (loss <5%). At D15 and D30, endothelial cell loss seemed to be closely correlated with immediate postoperative edema (Pearson correlation coefficient between central corneal edema at H2 and endothelial cells loss at 1 monthr = 0.4, P < 0.0001).
CONCLUSIONS:Postoperative corneal thickness measurement may therefore become a marker of endothelial damage after phacoemulsification.</abstract><cop>United States</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>29303887</pmid><doi>10.1097/ICO.0000000000001502</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Cell Count Corneal Edema - pathology Corneal Endothelial Cell Loss - pathology Corneal Pachymetry Female Humans Male Middle Aged Phacoemulsification - adverse effects Phacoemulsification - methods Postoperative Complications - pathology Prospective Studies |
| title | Correlation Between Postoperative Central Corneal Thickness and Endothelial Damage After Cataract Surgery by Phacoemulsification |
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