Capturing Totipotent Stem Cells
Minority subpopulations within embryonic stem cell cultures display an expanded developmental potential similar to that of early embryo blastomeres or the early inner cell mass. The ability to isolate and culture totipotent cells capable of giving rise to the entire conceptus would enhance our capac...
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| Veröffentlicht in: | Cell stem cell 2018-01, Vol.22 (1), p.25-34 |
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| container_title | Cell stem cell |
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| creator | Baker, Christopher L. Pera, Martin F. |
| description | Minority subpopulations within embryonic stem cell cultures display an expanded developmental potential similar to that of early embryo blastomeres or the early inner cell mass. The ability to isolate and culture totipotent cells capable of giving rise to the entire conceptus would enhance our capacity to study early embryo development, and might enable more efficient generation of chimeric animals for research and organ production for transplantation. Here we review the biological and molecular characterization of cultured cells with developmental potential similar to totipotent blastomeres, and assess recent progress toward the capture and stabilization of the totipotent state in vitro.
Baker and Pera review the biological and molecular characterization of cultured cells with developmental potential similar to totipotent blastomeres, and assess recent progress toward the capture and stabilization of the totipotent state in vitro. |
| doi_str_mv | 10.1016/j.stem.2017.12.011 |
| format | Article |
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Baker and Pera review the biological and molecular characterization of cultured cells with developmental potential similar to totipotent blastomeres, and assess recent progress toward the capture and stabilization of the totipotent state in vitro.</description><subject>Animals</subject><subject>Cell Differentiation</subject><subject>chimera</subject><subject>chromatin</subject><subject>Embryo, Mammalian - cytology</subject><subject>Embryonic Development</subject><subject>Embryonic Stem Cells - cytology</subject><subject>Humans</subject><subject>mouse and human embryo</subject><subject>pluripotent stem cell</subject><subject>primitive endoderm</subject><subject>Signal Transduction</subject><subject>totipotent stem cell</subject><subject>Totipotent Stem Cells - cytology</subject><subject>trophoblast</subject><subject>two-cell stage</subject><issn>1934-5909</issn><issn>1875-9777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwBxigI0uCzx-1LbGgiC-pEgNlthzHQa7aJNgOEv8eVy2MTHfD8766exC6BFwChsXtuozJbUuCQZRASgxwhKYgBS-UEOI474qygiusJugsxjXGXAAWp2hCFMWMMjxF15UZ0hh89zFf9ckPfXJdmr_l3nnlNpt4jk5as4nu4jBn6P3xYVU9F8vXp5fqfllYhnEqJHAsBRGUEWYo5bKtJeac8YYrZxYGG8tMSyh3oEDWBpqat7Y1AgyplZB0hm72vUPoP0cXk976aPMFpnP9GDUoqTjlYiEySvaoDX2MwbV6CH5rwrcGrHdi9FrvxOidGA1EZzE5dHXoH-uta_4ivyYycLcHXP7yy7ugo_Wus67xwdmkm97_1_8DNo1yIw</recordid><startdate>20180104</startdate><enddate>20180104</enddate><creator>Baker, Christopher L.</creator><creator>Pera, Martin F.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180104</creationdate><title>Capturing Totipotent Stem Cells</title><author>Baker, Christopher L. ; Pera, Martin F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-815087273424a3358fb805545d59ea6a0ac4af235e1918ba1db5fcfa71a2b9783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Cell Differentiation</topic><topic>chimera</topic><topic>chromatin</topic><topic>Embryo, Mammalian - cytology</topic><topic>Embryonic Development</topic><topic>Embryonic Stem Cells - cytology</topic><topic>Humans</topic><topic>mouse and human embryo</topic><topic>pluripotent stem cell</topic><topic>primitive endoderm</topic><topic>Signal Transduction</topic><topic>totipotent stem cell</topic><topic>Totipotent Stem Cells - cytology</topic><topic>trophoblast</topic><topic>two-cell stage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baker, Christopher L.</creatorcontrib><creatorcontrib>Pera, Martin F.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell stem cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baker, Christopher L.</au><au>Pera, Martin F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Capturing Totipotent Stem Cells</atitle><jtitle>Cell stem cell</jtitle><addtitle>Cell Stem Cell</addtitle><date>2018-01-04</date><risdate>2018</risdate><volume>22</volume><issue>1</issue><spage>25</spage><epage>34</epage><pages>25-34</pages><issn>1934-5909</issn><eissn>1875-9777</eissn><abstract>Minority subpopulations within embryonic stem cell cultures display an expanded developmental potential similar to that of early embryo blastomeres or the early inner cell mass. The ability to isolate and culture totipotent cells capable of giving rise to the entire conceptus would enhance our capacity to study early embryo development, and might enable more efficient generation of chimeric animals for research and organ production for transplantation. Here we review the biological and molecular characterization of cultured cells with developmental potential similar to totipotent blastomeres, and assess recent progress toward the capture and stabilization of the totipotent state in vitro.
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| fulltext | fulltext |
| identifier | ISSN: 1934-5909 |
| ispartof | Cell stem cell, 2018-01, Vol.22 (1), p.25-34 |
| issn | 1934-5909 1875-9777 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1989535767 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Cell Differentiation chimera chromatin Embryo, Mammalian - cytology Embryonic Development Embryonic Stem Cells - cytology Humans mouse and human embryo pluripotent stem cell primitive endoderm Signal Transduction totipotent stem cell Totipotent Stem Cells - cytology trophoblast two-cell stage |
| title | Capturing Totipotent Stem Cells |
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