The association between metabolic syndrome and its components with systemic lupus erythematosus: a comprehensive systematic review and meta-analysis of observational studies
Objectives Based upon inflammatory-related factors in chronic systemic lupus erythematosus (SLE), as well as the long-term prescription of corticosteroids, metabolic syndrome (MetS) prevalence is expected to be higher in SLE patients than among those without SLE. The aim of this study was to systema...
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| Veröffentlicht in: | Lupus 2018-05, Vol.27 (6), p.899-912 |
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| creator | Hallajzadeh, J Khoramdad, M Izadi, N Karamzad, N Almasi-Hashiani, A Ayubi, E Qorbani, M Pakzad, R Sullman, M J M Safiri, S |
| description | Objectives
Based upon inflammatory-related factors in chronic systemic lupus erythematosus (SLE), as well as the long-term prescription of corticosteroids, metabolic syndrome (MetS) prevalence is expected to be higher in SLE patients than among those without SLE. The aim of this study was to systematically analyze: (1) the worldwide prevalence of MetS in patients with SLE using different criteria, (2) the risk of MetS in patients with SLE compared with those without SLE, and (3) the risk of MetS component in patients with SLE compared with healthy controls.
Methods
We searched international databases, such as: Web of Science, Medline, PubMed, Scopus, Embase, CABI, CINAHL, DOAJ and Google Scholar. The articles which reported the prevalence of MetS in SLE patients, between 2006 and 2017, were included in the study if they had a: clear study design, study time and location, sound sampling approach and appropriate statistical analyses. Studies without sufficient data to determine the prevalence of MetS were excluded. Also, studies in patients suffering from other clinical diseases were not included.
Results
The meta-analyses of the prevalence (40 studies (n = 6085)) and risk (20 studies (n = 2348)) of MetS in SLE patients were conducted separately. The pooled prevalence of MetS among SLE patients was found to be 26% (95% confidence interval (CI): 22–30%), but varied from 18% (95% CI: 11–25%) to 34% (95% CI: 25–42%), depending upon the diagnostic criteria used. The overall pooled odds ratio (OR) of MetS in SLE patients, compared with healthy controls, was (OR = 2.50; 95% CI: 1.86–3.35), but this ranged from (OR = 1.23; 95% CI: 0.61–2.49) to (OR = 10.71; 95% CI: 1.33–86.48), depending upon the criteria used. Also, the risk of high fasting blood sugar (FBS; OR = 1.59; 95% CI: 1.05–2.40), low high-density lipoprotein cholesterol (HDL-C; OR = 1.43; 95% CI: 1.02–2.01), high blood pressure (BP; OR = 2.76; 95% CI: 2.19–3.47), high triglycerides (TG; OR = 2.85; 95% CI: 2.05–3.95) and high waist circumference (WC; OR = 1.37; 95% CI: 0.97–1.94) were all found to be higher in SLE patients compared with healthy controls.
Conclusions
The risk of MetS was significantly higher in SLE patients, compared with healthy controls, even after adjusting for publication bias. Among MetS components, high TG and high BP were most strongly associated with SLE. Considering that high TG and high BP are preventable, there is an international need to implement effective interventions to redu |
| doi_str_mv | 10.1177/0961203317751047 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1989535688</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0961203317751047</sage_id><sourcerecordid>1989535688</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-ce99e586384d4ab667d4436f1c466848cc0f6485fd98215a8f95fd94c6b616c43</originalsourceid><addsrcrecordid>eNp1kU9v1DAQxS0EokvLnROyxIVLwF47js0NVfyTKvXSniPHmbCuEnvxOLvaD8V3xNldQKrUk588v3lvNEPIG84-cN40H5lRfM2EKLrmTDbPyIrLpqnK__o5WS3laqlfkFeID4wxwY16SS7WRrAC8hX5fbcBahGj8zb7GGgHeQ8Q6ATZdnH0juIh9ClOBQs99Rmpi9M2BghF7n3eFAAzTIUc5-2MFNIhb2CyOeKMn6g98gk2ENDv4EyXMEcT7Dzsj75LXGWDHQ_okcaBxg4h7Y4z2ZFinnsPeEVeDHZEeH1-L8n91y9319-rm9tvP64_31ROqDpXDoyBWiuhZS9tp1TTSynUwJ1USkvtHBuU1PXQG73mtdWDWbR0qlNcOSkuyfuT7zbFXzNgbiePDsbRBogzttxoU4taaV3Qd4_QhzinMjO2ZfNKGV2gQrET5VJETDC02-Qnmw4tZ-1yyvbxKUvL27Px3E3Q_2v4e7sCVCcA7U_4n_qk4R8BL6pn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2036698883</pqid></control><display><type>article</type><title>The association between metabolic syndrome and its components with systemic lupus erythematosus: a comprehensive systematic review and meta-analysis of observational studies</title><source>Access via SAGE</source><creator>Hallajzadeh, J ; Khoramdad, M ; Izadi, N ; Karamzad, N ; Almasi-Hashiani, A ; Ayubi, E ; Qorbani, M ; Pakzad, R ; Sullman, M J M ; Safiri, S</creator><creatorcontrib>Hallajzadeh, J ; Khoramdad, M ; Izadi, N ; Karamzad, N ; Almasi-Hashiani, A ; Ayubi, E ; Qorbani, M ; Pakzad, R ; Sullman, M J M ; Safiri, S</creatorcontrib><description>Objectives
Based upon inflammatory-related factors in chronic systemic lupus erythematosus (SLE), as well as the long-term prescription of corticosteroids, metabolic syndrome (MetS) prevalence is expected to be higher in SLE patients than among those without SLE. The aim of this study was to systematically analyze: (1) the worldwide prevalence of MetS in patients with SLE using different criteria, (2) the risk of MetS in patients with SLE compared with those without SLE, and (3) the risk of MetS component in patients with SLE compared with healthy controls.
Methods
We searched international databases, such as: Web of Science, Medline, PubMed, Scopus, Embase, CABI, CINAHL, DOAJ and Google Scholar. The articles which reported the prevalence of MetS in SLE patients, between 2006 and 2017, were included in the study if they had a: clear study design, study time and location, sound sampling approach and appropriate statistical analyses. Studies without sufficient data to determine the prevalence of MetS were excluded. Also, studies in patients suffering from other clinical diseases were not included.
Results
The meta-analyses of the prevalence (40 studies (n = 6085)) and risk (20 studies (n = 2348)) of MetS in SLE patients were conducted separately. The pooled prevalence of MetS among SLE patients was found to be 26% (95% confidence interval (CI): 22–30%), but varied from 18% (95% CI: 11–25%) to 34% (95% CI: 25–42%), depending upon the diagnostic criteria used. The overall pooled odds ratio (OR) of MetS in SLE patients, compared with healthy controls, was (OR = 2.50; 95% CI: 1.86–3.35), but this ranged from (OR = 1.23; 95% CI: 0.61–2.49) to (OR = 10.71; 95% CI: 1.33–86.48), depending upon the criteria used. Also, the risk of high fasting blood sugar (FBS; OR = 1.59; 95% CI: 1.05–2.40), low high-density lipoprotein cholesterol (HDL-C; OR = 1.43; 95% CI: 1.02–2.01), high blood pressure (BP; OR = 2.76; 95% CI: 2.19–3.47), high triglycerides (TG; OR = 2.85; 95% CI: 2.05–3.95) and high waist circumference (WC; OR = 1.37; 95% CI: 0.97–1.94) were all found to be higher in SLE patients compared with healthy controls.
Conclusions
The risk of MetS was significantly higher in SLE patients, compared with healthy controls, even after adjusting for publication bias. Among MetS components, high TG and high BP were most strongly associated with SLE. Considering that high TG and high BP are preventable, there is an international need to implement effective interventions to reduce MetS components in SLE patients in order to prevent serious outcomes such as cardiovascular diseases and mortality.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203317751047</identifier><identifier>PMID: 29301471</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Blood pressure ; Cardiovascular diseases ; Cholesterol ; Corticosteroids ; High density lipoprotein ; Hypertension ; Inflammation ; Lupus ; Meta-analysis ; Metabolic syndrome ; Observational studies ; Statistical analysis ; Studies ; Sugar ; Systematic review ; Systemic lupus erythematosus ; Triglycerides</subject><ispartof>Lupus, 2018-05, Vol.27 (6), p.899-912</ispartof><rights>The Author(s) 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-ce99e586384d4ab667d4436f1c466848cc0f6485fd98215a8f95fd94c6b616c43</citedby><cites>FETCH-LOGICAL-c365t-ce99e586384d4ab667d4436f1c466848cc0f6485fd98215a8f95fd94c6b616c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0961203317751047$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0961203317751047$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,782,786,21826,27931,27932,43628,43629</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29301471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hallajzadeh, J</creatorcontrib><creatorcontrib>Khoramdad, M</creatorcontrib><creatorcontrib>Izadi, N</creatorcontrib><creatorcontrib>Karamzad, N</creatorcontrib><creatorcontrib>Almasi-Hashiani, A</creatorcontrib><creatorcontrib>Ayubi, E</creatorcontrib><creatorcontrib>Qorbani, M</creatorcontrib><creatorcontrib>Pakzad, R</creatorcontrib><creatorcontrib>Sullman, M J M</creatorcontrib><creatorcontrib>Safiri, S</creatorcontrib><title>The association between metabolic syndrome and its components with systemic lupus erythematosus: a comprehensive systematic review and meta-analysis of observational studies</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Objectives
Based upon inflammatory-related factors in chronic systemic lupus erythematosus (SLE), as well as the long-term prescription of corticosteroids, metabolic syndrome (MetS) prevalence is expected to be higher in SLE patients than among those without SLE. The aim of this study was to systematically analyze: (1) the worldwide prevalence of MetS in patients with SLE using different criteria, (2) the risk of MetS in patients with SLE compared with those without SLE, and (3) the risk of MetS component in patients with SLE compared with healthy controls.
Methods
We searched international databases, such as: Web of Science, Medline, PubMed, Scopus, Embase, CABI, CINAHL, DOAJ and Google Scholar. The articles which reported the prevalence of MetS in SLE patients, between 2006 and 2017, were included in the study if they had a: clear study design, study time and location, sound sampling approach and appropriate statistical analyses. Studies without sufficient data to determine the prevalence of MetS were excluded. Also, studies in patients suffering from other clinical diseases were not included.
Results
The meta-analyses of the prevalence (40 studies (n = 6085)) and risk (20 studies (n = 2348)) of MetS in SLE patients were conducted separately. The pooled prevalence of MetS among SLE patients was found to be 26% (95% confidence interval (CI): 22–30%), but varied from 18% (95% CI: 11–25%) to 34% (95% CI: 25–42%), depending upon the diagnostic criteria used. The overall pooled odds ratio (OR) of MetS in SLE patients, compared with healthy controls, was (OR = 2.50; 95% CI: 1.86–3.35), but this ranged from (OR = 1.23; 95% CI: 0.61–2.49) to (OR = 10.71; 95% CI: 1.33–86.48), depending upon the criteria used. Also, the risk of high fasting blood sugar (FBS; OR = 1.59; 95% CI: 1.05–2.40), low high-density lipoprotein cholesterol (HDL-C; OR = 1.43; 95% CI: 1.02–2.01), high blood pressure (BP; OR = 2.76; 95% CI: 2.19–3.47), high triglycerides (TG; OR = 2.85; 95% CI: 2.05–3.95) and high waist circumference (WC; OR = 1.37; 95% CI: 0.97–1.94) were all found to be higher in SLE patients compared with healthy controls.
Conclusions
The risk of MetS was significantly higher in SLE patients, compared with healthy controls, even after adjusting for publication bias. Among MetS components, high TG and high BP were most strongly associated with SLE. Considering that high TG and high BP are preventable, there is an international need to implement effective interventions to reduce MetS components in SLE patients in order to prevent serious outcomes such as cardiovascular diseases and mortality.</description><subject>Blood pressure</subject><subject>Cardiovascular diseases</subject><subject>Cholesterol</subject><subject>Corticosteroids</subject><subject>High density lipoprotein</subject><subject>Hypertension</subject><subject>Inflammation</subject><subject>Lupus</subject><subject>Meta-analysis</subject><subject>Metabolic syndrome</subject><subject>Observational studies</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Sugar</subject><subject>Systematic review</subject><subject>Systemic lupus erythematosus</subject><subject>Triglycerides</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kU9v1DAQxS0EokvLnROyxIVLwF47js0NVfyTKvXSniPHmbCuEnvxOLvaD8V3xNldQKrUk588v3lvNEPIG84-cN40H5lRfM2EKLrmTDbPyIrLpqnK__o5WS3laqlfkFeID4wxwY16SS7WRrAC8hX5fbcBahGj8zb7GGgHeQ8Q6ATZdnH0juIh9ClOBQs99Rmpi9M2BghF7n3eFAAzTIUc5-2MFNIhb2CyOeKMn6g98gk2ENDv4EyXMEcT7Dzsj75LXGWDHQ_okcaBxg4h7Y4z2ZFinnsPeEVeDHZEeH1-L8n91y9319-rm9tvP64_31ROqDpXDoyBWiuhZS9tp1TTSynUwJ1USkvtHBuU1PXQG73mtdWDWbR0qlNcOSkuyfuT7zbFXzNgbiePDsbRBogzttxoU4taaV3Qd4_QhzinMjO2ZfNKGV2gQrET5VJETDC02-Qnmw4tZ-1yyvbxKUvL27Px3E3Q_2v4e7sCVCcA7U_4n_qk4R8BL6pn</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Hallajzadeh, J</creator><creator>Khoramdad, M</creator><creator>Izadi, N</creator><creator>Karamzad, N</creator><creator>Almasi-Hashiani, A</creator><creator>Ayubi, E</creator><creator>Qorbani, M</creator><creator>Pakzad, R</creator><creator>Sullman, M J M</creator><creator>Safiri, S</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201805</creationdate><title>The association between metabolic syndrome and its components with systemic lupus erythematosus: a comprehensive systematic review and meta-analysis of observational studies</title><author>Hallajzadeh, J ; Khoramdad, M ; Izadi, N ; Karamzad, N ; Almasi-Hashiani, A ; Ayubi, E ; Qorbani, M ; Pakzad, R ; Sullman, M J M ; Safiri, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-ce99e586384d4ab667d4436f1c466848cc0f6485fd98215a8f95fd94c6b616c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Blood pressure</topic><topic>Cardiovascular diseases</topic><topic>Cholesterol</topic><topic>Corticosteroids</topic><topic>High density lipoprotein</topic><topic>Hypertension</topic><topic>Inflammation</topic><topic>Lupus</topic><topic>Meta-analysis</topic><topic>Metabolic syndrome</topic><topic>Observational studies</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Sugar</topic><topic>Systematic review</topic><topic>Systemic lupus erythematosus</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hallajzadeh, J</creatorcontrib><creatorcontrib>Khoramdad, M</creatorcontrib><creatorcontrib>Izadi, N</creatorcontrib><creatorcontrib>Karamzad, N</creatorcontrib><creatorcontrib>Almasi-Hashiani, A</creatorcontrib><creatorcontrib>Ayubi, E</creatorcontrib><creatorcontrib>Qorbani, M</creatorcontrib><creatorcontrib>Pakzad, R</creatorcontrib><creatorcontrib>Sullman, M J M</creatorcontrib><creatorcontrib>Safiri, S</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hallajzadeh, J</au><au>Khoramdad, M</au><au>Izadi, N</au><au>Karamzad, N</au><au>Almasi-Hashiani, A</au><au>Ayubi, E</au><au>Qorbani, M</au><au>Pakzad, R</au><au>Sullman, M J M</au><au>Safiri, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between metabolic syndrome and its components with systemic lupus erythematosus: a comprehensive systematic review and meta-analysis of observational studies</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2018-05</date><risdate>2018</risdate><volume>27</volume><issue>6</issue><spage>899</spage><epage>912</epage><pages>899-912</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Objectives
Based upon inflammatory-related factors in chronic systemic lupus erythematosus (SLE), as well as the long-term prescription of corticosteroids, metabolic syndrome (MetS) prevalence is expected to be higher in SLE patients than among those without SLE. The aim of this study was to systematically analyze: (1) the worldwide prevalence of MetS in patients with SLE using different criteria, (2) the risk of MetS in patients with SLE compared with those without SLE, and (3) the risk of MetS component in patients with SLE compared with healthy controls.
Methods
We searched international databases, such as: Web of Science, Medline, PubMed, Scopus, Embase, CABI, CINAHL, DOAJ and Google Scholar. The articles which reported the prevalence of MetS in SLE patients, between 2006 and 2017, were included in the study if they had a: clear study design, study time and location, sound sampling approach and appropriate statistical analyses. Studies without sufficient data to determine the prevalence of MetS were excluded. Also, studies in patients suffering from other clinical diseases were not included.
Results
The meta-analyses of the prevalence (40 studies (n = 6085)) and risk (20 studies (n = 2348)) of MetS in SLE patients were conducted separately. The pooled prevalence of MetS among SLE patients was found to be 26% (95% confidence interval (CI): 22–30%), but varied from 18% (95% CI: 11–25%) to 34% (95% CI: 25–42%), depending upon the diagnostic criteria used. The overall pooled odds ratio (OR) of MetS in SLE patients, compared with healthy controls, was (OR = 2.50; 95% CI: 1.86–3.35), but this ranged from (OR = 1.23; 95% CI: 0.61–2.49) to (OR = 10.71; 95% CI: 1.33–86.48), depending upon the criteria used. Also, the risk of high fasting blood sugar (FBS; OR = 1.59; 95% CI: 1.05–2.40), low high-density lipoprotein cholesterol (HDL-C; OR = 1.43; 95% CI: 1.02–2.01), high blood pressure (BP; OR = 2.76; 95% CI: 2.19–3.47), high triglycerides (TG; OR = 2.85; 95% CI: 2.05–3.95) and high waist circumference (WC; OR = 1.37; 95% CI: 0.97–1.94) were all found to be higher in SLE patients compared with healthy controls.
Conclusions
The risk of MetS was significantly higher in SLE patients, compared with healthy controls, even after adjusting for publication bias. Among MetS components, high TG and high BP were most strongly associated with SLE. Considering that high TG and high BP are preventable, there is an international need to implement effective interventions to reduce MetS components in SLE patients in order to prevent serious outcomes such as cardiovascular diseases and mortality.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>29301471</pmid><doi>10.1177/0961203317751047</doi><tpages>14</tpages></addata></record> |
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| subjects | Blood pressure Cardiovascular diseases Cholesterol Corticosteroids High density lipoprotein Hypertension Inflammation Lupus Meta-analysis Metabolic syndrome Observational studies Statistical analysis Studies Sugar Systematic review Systemic lupus erythematosus Triglycerides |
| title | The association between metabolic syndrome and its components with systemic lupus erythematosus: a comprehensive systematic review and meta-analysis of observational studies |
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