Risk of cardiovascular mortality predicted by the serum calcium level and calcification score at the initiation of dialysis
Background The relationship between serum corrected calcium (CCa) level and vessel calcification at dialysis initiation and survival has seldom been evaluated. Therefore, we evaluated the efficacy of CCa levels and the calcification score at the initiation of dialysis for predicting all-cause and ca...
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| Veröffentlicht in: | Clinical and experimental nephrology 2018-08, Vol.22 (4), p.957-966 |
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| creator | Sato, Hiroyuki Nagasawa, Tasuku Saito, Ayako Miyazaki, Mariko |
| description | Background
The relationship between serum corrected calcium (CCa) level and vessel calcification at dialysis initiation and survival has seldom been evaluated. Therefore, we evaluated the efficacy of CCa levels and the calcification score at the initiation of dialysis for predicting all-cause and cardiovascular (CV) mortality in patients with end-stage renal disease (ESRD).
Methods
The study group included 407 patients with ESRD, who started hemodialysis between January 2009 and December 2016 at the Red Cross Ishinomaki Hospital. The primary outcomes were the 1- and 3-year all-cause and CV mortality rate, with the association between CCa level and CVD-specific mortality evaluated using the Kaplan–Meier method and Cox proportional hazard regression analysis.
Results
Patients with a high initial CCa level were at higher risk for CVD-related, but not all-cause, mortality than patients with a low initial CCa level [hazard ratio (HR) 2.81; 95% confidence interval 1.05–7.55]. The HR for CVD-related mortality was also higher for patients with an Agatston vessel calcification score > 2000 (HR 13.9; 95% CI 1.63–118.2). Overall, the 3-year CVD-free rate was 88.2% (range 76.4–94.3%). Higher CCa level was associated with a higher Agatston score and cardiac valve calcification.
Conclusion
High serum CCa levels and an Agatston score > 2000 are independent risk factors of CVD mortality due to advanced vessel calcification. |
| doi_str_mv | 10.1007/s10157-017-1527-1 |
| format | Article |
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The relationship between serum corrected calcium (CCa) level and vessel calcification at dialysis initiation and survival has seldom been evaluated. Therefore, we evaluated the efficacy of CCa levels and the calcification score at the initiation of dialysis for predicting all-cause and cardiovascular (CV) mortality in patients with end-stage renal disease (ESRD).
Methods
The study group included 407 patients with ESRD, who started hemodialysis between January 2009 and December 2016 at the Red Cross Ishinomaki Hospital. The primary outcomes were the 1- and 3-year all-cause and CV mortality rate, with the association between CCa level and CVD-specific mortality evaluated using the Kaplan–Meier method and Cox proportional hazard regression analysis.
Results
Patients with a high initial CCa level were at higher risk for CVD-related, but not all-cause, mortality than patients with a low initial CCa level [hazard ratio (HR) 2.81; 95% confidence interval 1.05–7.55]. The HR for CVD-related mortality was also higher for patients with an Agatston vessel calcification score > 2000 (HR 13.9; 95% CI 1.63–118.2). Overall, the 3-year CVD-free rate was 88.2% (range 76.4–94.3%). Higher CCa level was associated with a higher Agatston score and cardiac valve calcification.
Conclusion
High serum CCa levels and an Agatston score > 2000 are independent risk factors of CVD mortality due to advanced vessel calcification.</description><identifier>ISSN: 1342-1751</identifier><identifier>EISSN: 1437-7799</identifier><identifier>DOI: 10.1007/s10157-017-1527-1</identifier><identifier>PMID: 29302867</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Aged ; Aged, 80 and over ; Calcification ; Calcification (ectopic) ; Calcium ; Calcium - blood ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - mortality ; End-stage renal disease ; Female ; Heart diseases ; Hemodialysis ; Humans ; Kidney diseases ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - complications ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Nephrology ; Original Article ; Proportional Hazards Models ; Renal Dialysis ; Retrospective Studies ; Risk Factors ; Urology</subject><ispartof>Clinical and experimental nephrology, 2018-08, Vol.22 (4), p.957-966</ispartof><rights>The Author(s) 2018</rights><rights>Clinical and Experimental Nephrology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-8ea5397b29ec9a6e1a78295ee199a264d37a0feed1fcd8e7c4517690ef31533a3</citedby><cites>FETCH-LOGICAL-c560t-8ea5397b29ec9a6e1a78295ee199a264d37a0feed1fcd8e7c4517690ef31533a3</cites><orcidid>0000-0002-7820-0219</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10157-017-1527-1$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10157-017-1527-1$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29302867$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, Hiroyuki</creatorcontrib><creatorcontrib>Nagasawa, Tasuku</creatorcontrib><creatorcontrib>Saito, Ayako</creatorcontrib><creatorcontrib>Miyazaki, Mariko</creatorcontrib><title>Risk of cardiovascular mortality predicted by the serum calcium level and calcification score at the initiation of dialysis</title><title>Clinical and experimental nephrology</title><addtitle>Clin Exp Nephrol</addtitle><addtitle>Clin Exp Nephrol</addtitle><description>Background
The relationship between serum corrected calcium (CCa) level and vessel calcification at dialysis initiation and survival has seldom been evaluated. Therefore, we evaluated the efficacy of CCa levels and the calcification score at the initiation of dialysis for predicting all-cause and cardiovascular (CV) mortality in patients with end-stage renal disease (ESRD).
Methods
The study group included 407 patients with ESRD, who started hemodialysis between January 2009 and December 2016 at the Red Cross Ishinomaki Hospital. The primary outcomes were the 1- and 3-year all-cause and CV mortality rate, with the association between CCa level and CVD-specific mortality evaluated using the Kaplan–Meier method and Cox proportional hazard regression analysis.
Results
Patients with a high initial CCa level were at higher risk for CVD-related, but not all-cause, mortality than patients with a low initial CCa level [hazard ratio (HR) 2.81; 95% confidence interval 1.05–7.55]. The HR for CVD-related mortality was also higher for patients with an Agatston vessel calcification score > 2000 (HR 13.9; 95% CI 1.63–118.2). Overall, the 3-year CVD-free rate was 88.2% (range 76.4–94.3%). Higher CCa level was associated with a higher Agatston score and cardiac valve calcification.
Conclusion
High serum CCa levels and an Agatston score > 2000 are independent risk factors of CVD mortality due to advanced vessel calcification.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>Calcium</subject><subject>Calcium - blood</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - complications</subject><subject>Cardiovascular Diseases - mortality</subject><subject>End-stage renal disease</subject><subject>Female</subject><subject>Heart diseases</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Nephrology</subject><subject>Original Article</subject><subject>Proportional Hazards Models</subject><subject>Renal Dialysis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Urology</subject><issn>1342-1751</issn><issn>1437-7799</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kVFrFTEQhYMotlZ_gC8S8KUvazPJZrN5lNKqUBBEn0NuMqup2c01yRYu_vnmulVE8CUTJt-cM-QQ8hLYG2BMXRRgIFXHQHUgeTsekVPoheqU0vpxu4ued6AknJBnpdwyxkYt9VNywrVgfBzUKfn5KZTvNE3U2exDurPFrdFmOqdcbQz1QPcZfXAVPd0daP2GtGBe58ZHF1qNeIeR2sVvnSk4W0NaaHEpI7X110hYQg1bv1n5YOOhhPKcPJlsLPjioZ6RL9dXny_fdzcf3324fHvTOTmw2o1opdBqxzU6bQcEq0auJSJobfnQe6EsmxA9TM6PqFwvQQ2a4SRACmHFGTnfdPc5_VixVDOH4jBGu2BaiwHdvkU0D9HQ1_-gt2nNS9vuSPUD56NmjYKNcjmVknEy-xxmmw8GmDkmY7ZkTEvGHJMx0GZePSivuxn9n4nfUTSAb0BpT8tXzH9Z_1f1Hsgamn0</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Sato, Hiroyuki</creator><creator>Nagasawa, Tasuku</creator><creator>Saito, Ayako</creator><creator>Miyazaki, Mariko</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7820-0219</orcidid></search><sort><creationdate>20180801</creationdate><title>Risk of cardiovascular mortality predicted by the serum calcium level and calcification score at the initiation of dialysis</title><author>Sato, Hiroyuki ; Nagasawa, Tasuku ; Saito, Ayako ; Miyazaki, Mariko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c560t-8ea5397b29ec9a6e1a78295ee199a264d37a0feed1fcd8e7c4517690ef31533a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Calcification</topic><topic>Calcification (ectopic)</topic><topic>Calcium</topic><topic>Calcium - blood</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - complications</topic><topic>Cardiovascular Diseases - mortality</topic><topic>End-stage renal disease</topic><topic>Female</topic><topic>Heart diseases</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Nephrology</topic><topic>Original Article</topic><topic>Proportional Hazards Models</topic><topic>Renal Dialysis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, Hiroyuki</creatorcontrib><creatorcontrib>Nagasawa, Tasuku</creatorcontrib><creatorcontrib>Saito, Ayako</creatorcontrib><creatorcontrib>Miyazaki, Mariko</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Hiroyuki</au><au>Nagasawa, Tasuku</au><au>Saito, Ayako</au><au>Miyazaki, Mariko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of cardiovascular mortality predicted by the serum calcium level and calcification score at the initiation of dialysis</atitle><jtitle>Clinical and experimental nephrology</jtitle><stitle>Clin Exp Nephrol</stitle><addtitle>Clin Exp Nephrol</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>22</volume><issue>4</issue><spage>957</spage><epage>966</epage><pages>957-966</pages><issn>1342-1751</issn><eissn>1437-7799</eissn><abstract>Background
The relationship between serum corrected calcium (CCa) level and vessel calcification at dialysis initiation and survival has seldom been evaluated. Therefore, we evaluated the efficacy of CCa levels and the calcification score at the initiation of dialysis for predicting all-cause and cardiovascular (CV) mortality in patients with end-stage renal disease (ESRD).
Methods
The study group included 407 patients with ESRD, who started hemodialysis between January 2009 and December 2016 at the Red Cross Ishinomaki Hospital. The primary outcomes were the 1- and 3-year all-cause and CV mortality rate, with the association between CCa level and CVD-specific mortality evaluated using the Kaplan–Meier method and Cox proportional hazard regression analysis.
Results
Patients with a high initial CCa level were at higher risk for CVD-related, but not all-cause, mortality than patients with a low initial CCa level [hazard ratio (HR) 2.81; 95% confidence interval 1.05–7.55]. The HR for CVD-related mortality was also higher for patients with an Agatston vessel calcification score > 2000 (HR 13.9; 95% CI 1.63–118.2). Overall, the 3-year CVD-free rate was 88.2% (range 76.4–94.3%). Higher CCa level was associated with a higher Agatston score and cardiac valve calcification.
Conclusion
High serum CCa levels and an Agatston score > 2000 are independent risk factors of CVD mortality due to advanced vessel calcification.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>29302867</pmid><doi>10.1007/s10157-017-1527-1</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7820-0219</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Calcification Calcification (ectopic) Calcium Calcium - blood Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - complications Cardiovascular Diseases - mortality End-stage renal disease Female Heart diseases Hemodialysis Humans Kidney diseases Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Male Medicine Medicine & Public Health Middle Aged Mortality Nephrology Original Article Proportional Hazards Models Renal Dialysis Retrospective Studies Risk Factors Urology |
| title | Risk of cardiovascular mortality predicted by the serum calcium level and calcification score at the initiation of dialysis |
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