The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves

Botulinum neurotoxins (BoNTs) inhibit neurotransmitter release by selectively cleaving core components of the vesicular fusion machinery. The synaptic vesicle proteins Synaptotagmin-I and -II act as receptors for BoNT/B and BoNT/G. Here we show that BoNT/A also interacts with a synaptic vesicle prot...

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Veröffentlicht in:	FEBS letters 2006-04, Vol.580 (8), p.2011-2014
Hauptverfasser:	Mahrhold, Stefan, Rummel, Andreas, Bigalke, Hans, Davletov, Bazbek, Binz, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	amino-terminal half of HC Animals BoNT Botulinum neurotoxin Botulinum Toxins, Type A - antagonists & inhibitors Botulinum Toxins, Type A - metabolism carboxyl-terminal half of HC Ganglioside heavy chain light chain Membrane Glycoproteins - metabolism Mice Nerve Tissue Proteins - metabolism Phrenic nerve Phrenic Nerve - metabolism Protein Binding Protein receptor Protein Structure, Tertiary Protein Transport Recombinant Fusion Proteins - metabolism SV2 Syg synaptic vesicle glycoprotein 2 Synaptogyrin synaptophysin Synaptoporin synaptotagmin Syo Syp Syt
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