A new bacterial mannosidase for the selective modification of ramoplanin and its derivatives
Ramoplanin is a lipoglycodepsipeptide produced by Actinoplanes sp. ATCC 33076 and active on bacterial cell wall biosynthesis by binding to Lipid II. A screening of an actinomycetes collection was performed to select enzymatic activities able to introduce specific modifications in the ramoplanin mole...
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| Veröffentlicht in: | Enzyme and microbial technology 2007-11, Vol.41 (6), p.806-811 |
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| container_title | Enzyme and microbial technology |
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| creator | Di Palo, Samuele Gandolfi, Raffaella Jovetic, Srdjan Marinelli, Flavia Romano, Diego Molinari, Francesco |
| description | Ramoplanin is a lipoglycodepsipeptide produced by
Actinoplanes sp. ATCC 33076 and active on bacterial cell wall biosynthesis by binding to Lipid II. A screening of an actinomycetes collection was performed to select enzymatic activities able to introduce specific modifications in the ramoplanin molecule. An extracellular mannosidase from
Streptomyces GE 91081 was found to selectively remove one mannose unit from ramoplanin and tetrahydroramoplanin to give the corresponding mannosyl aglycones. These molecules show an improved microbiological activity versus some resistant staphylococci and streptococci, and are useful intermediates in the synthesis of novel ramoplanin-like antibiotics. The biotransformation of ramoplanin has been optimised to improve molar conversion and the transformation reaction rate. |
| doi_str_mv | 10.1016/j.enzmictec.2007.07.013 |
| format | Article |
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Actinoplanes sp. ATCC 33076 and active on bacterial cell wall biosynthesis by binding to Lipid II. A screening of an actinomycetes collection was performed to select enzymatic activities able to introduce specific modifications in the ramoplanin molecule. An extracellular mannosidase from
Streptomyces GE 91081 was found to selectively remove one mannose unit from ramoplanin and tetrahydroramoplanin to give the corresponding mannosyl aglycones. These molecules show an improved microbiological activity versus some resistant staphylococci and streptococci, and are useful intermediates in the synthesis of novel ramoplanin-like antibiotics. The biotransformation of ramoplanin has been optimised to improve molar conversion and the transformation reaction rate.</description><identifier>ISSN: 0141-0229</identifier><identifier>EISSN: 1879-0909</identifier><identifier>DOI: 10.1016/j.enzmictec.2007.07.013</identifier><identifier>CODEN: EMTED2</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Actinoplanes ; Antibiotic ; Bacteria ; Biological and medical sciences ; Biotechnology ; Biotransformation ; Fundamental and applied biological sciences. Psychology ; Lipoglycodepsipeptide ; Ramoplanin ; Streptomyces</subject><ispartof>Enzyme and microbial technology, 2007-11, Vol.41 (6), p.806-811</ispartof><rights>2007 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-d89be11b667adca91465542c86e9ae3c7abbc77fbfb4aab6196689d5a70d5a0e3</citedby><cites>FETCH-LOGICAL-c376t-d89be11b667adca91465542c86e9ae3c7abbc77fbfb4aab6196689d5a70d5a0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0141022907002384$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19066645$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Di Palo, Samuele</creatorcontrib><creatorcontrib>Gandolfi, Raffaella</creatorcontrib><creatorcontrib>Jovetic, Srdjan</creatorcontrib><creatorcontrib>Marinelli, Flavia</creatorcontrib><creatorcontrib>Romano, Diego</creatorcontrib><creatorcontrib>Molinari, Francesco</creatorcontrib><title>A new bacterial mannosidase for the selective modification of ramoplanin and its derivatives</title><title>Enzyme and microbial technology</title><description>Ramoplanin is a lipoglycodepsipeptide produced by
Actinoplanes sp. ATCC 33076 and active on bacterial cell wall biosynthesis by binding to Lipid II. A screening of an actinomycetes collection was performed to select enzymatic activities able to introduce specific modifications in the ramoplanin molecule. An extracellular mannosidase from
Streptomyces GE 91081 was found to selectively remove one mannose unit from ramoplanin and tetrahydroramoplanin to give the corresponding mannosyl aglycones. These molecules show an improved microbiological activity versus some resistant staphylococci and streptococci, and are useful intermediates in the synthesis of novel ramoplanin-like antibiotics. The biotransformation of ramoplanin has been optimised to improve molar conversion and the transformation reaction rate.</description><subject>Actinoplanes</subject><subject>Antibiotic</subject><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Biotransformation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lipoglycodepsipeptide</subject><subject>Ramoplanin</subject><subject>Streptomyces</subject><issn>0141-0229</issn><issn>1879-0909</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LAzEQhoMoWKu_wVz0tjXpbpPNsRS_oOBFb0KYTWYxZTepybaiv94sFT0KwwwMzzsfLyGXnM044-JmM0P_1TszoJnNGZOzMXh5RCa8lqpgiqljMmG84gWbz9UpOUtpw1huVGxCXpfU4wdtIOujg4724H1IzkJC2oZIhzekCTs0g9sj7YN1rTMwuOBpaGmEPmw78M5T8Ja6IVGb5-xhpNM5OWmhS3jxU6fk5e72efVQrJ_uH1fLdWFKKYbC1qpBzhshJFgDildisajmphaoAEsjoWmMlG3TNhVAI7gSolZ2AZLlxLCckuvD3G0M7ztMg-5dMtjlwzDskuaqVlX-PYPyAJoYUorY6m10PcRPzZke3dQb_eumHt3UY_AyK69-VkAy0LURvHHpT66YEKJaZG554DD_u3cYdTIOvUHrYvZQ2-D-3fUNoVmRlA</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Di Palo, Samuele</creator><creator>Gandolfi, Raffaella</creator><creator>Jovetic, Srdjan</creator><creator>Marinelli, Flavia</creator><creator>Romano, Diego</creator><creator>Molinari, Francesco</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20071101</creationdate><title>A new bacterial mannosidase for the selective modification of ramoplanin and its derivatives</title><author>Di Palo, Samuele ; Gandolfi, Raffaella ; Jovetic, Srdjan ; Marinelli, Flavia ; Romano, Diego ; Molinari, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-d89be11b667adca91465542c86e9ae3c7abbc77fbfb4aab6196689d5a70d5a0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Actinoplanes</topic><topic>Antibiotic</topic><topic>Bacteria</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Biotransformation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Lipoglycodepsipeptide</topic><topic>Ramoplanin</topic><topic>Streptomyces</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Di Palo, Samuele</creatorcontrib><creatorcontrib>Gandolfi, Raffaella</creatorcontrib><creatorcontrib>Jovetic, Srdjan</creatorcontrib><creatorcontrib>Marinelli, Flavia</creatorcontrib><creatorcontrib>Romano, Diego</creatorcontrib><creatorcontrib>Molinari, Francesco</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Enzyme and microbial technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Palo, Samuele</au><au>Gandolfi, Raffaella</au><au>Jovetic, Srdjan</au><au>Marinelli, Flavia</au><au>Romano, Diego</au><au>Molinari, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new bacterial mannosidase for the selective modification of ramoplanin and its derivatives</atitle><jtitle>Enzyme and microbial technology</jtitle><date>2007-11-01</date><risdate>2007</risdate><volume>41</volume><issue>6</issue><spage>806</spage><epage>811</epage><pages>806-811</pages><issn>0141-0229</issn><eissn>1879-0909</eissn><coden>EMTED2</coden><abstract>Ramoplanin is a lipoglycodepsipeptide produced by
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Streptomyces GE 91081 was found to selectively remove one mannose unit from ramoplanin and tetrahydroramoplanin to give the corresponding mannosyl aglycones. These molecules show an improved microbiological activity versus some resistant staphylococci and streptococci, and are useful intermediates in the synthesis of novel ramoplanin-like antibiotics. The biotransformation of ramoplanin has been optimised to improve molar conversion and the transformation reaction rate.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><doi>10.1016/j.enzmictec.2007.07.013</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Enzyme and microbial technology, 2007-11, Vol.41 (6), p.806-811 |
| issn | 0141-0229 1879-0909 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Actinoplanes Antibiotic Bacteria Biological and medical sciences Biotechnology Biotransformation Fundamental and applied biological sciences. Psychology Lipoglycodepsipeptide Ramoplanin Streptomyces |
| title | A new bacterial mannosidase for the selective modification of ramoplanin and its derivatives |
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