The role of TRPV6 in breast carcinogenesis

TRPV6 is an endothelial calcium entry channel that is strongly expressed in breast adenocarcinoma tissue. In this study, we further confirmed this observation by analysis of breast cancer tissues, which indicated that TRPV6 mRNA expression was up-regulated between 2-fold and 15-fold compared with th...

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Veröffentlicht in:	Molecular cancer therapeutics 2008-02, Vol.7 (2), p.271-279
Hauptverfasser:	Bolanz, Katrin A, Hediger, Matthias A, Landowski, Christopher P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - etiology Adenocarcinoma - genetics Adenocarcinoma - metabolism Antineoplastic Agents, Hormonal - pharmacology breast cancer Breast Neoplasms - etiology Breast Neoplasms - genetics Breast Neoplasms - metabolism calcium Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium Channels - genetics Calcium Channels - metabolism Calcium Channels - physiology estrogen Gene Expression Regulation, Neoplastic - drug effects Humans RNA, Messenger - metabolism RNA, Small Interfering - pharmacology tamoxifen Tamoxifen - pharmacology TRPV Cation Channels - antagonists & inhibitors TRPV Cation Channels - genetics TRPV Cation Channels - metabolism TRPV Cation Channels - physiology TRPV6 Tumor Cells, Cultured
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