Use of a Recombinant Fluorescent Substrate with Cleavage Sites for All Botulinum Neurotoxins in High-Throughput Screening of Natural Product Extracts for Inhibitors of Serotypes A, B, and E

The seven serotypes of botulinum neurotoxin (BoNTs) are zinc metalloproteases that cleave and inactivate proteins critical for neurotransmission. The synaptosomal protein of 25 kDa (SNAP-25) is cleaved by BoNTs A, C, and E, while vesicle-associated membrane protein (VAMP) is the substrate for BoNTs...

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Veröffentlicht in:Applied and Environmental Microbiology 2008-02, Vol.74 (3), p.653-659
Hauptverfasser: Hines, Harry B, Kim, Alexander D, Stafford, Robert G, Badie, Shirin S, Brueggeman, Ernst E, Newman, David J, Schmidt, James J
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Sprache:eng
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