Specific Inhibition of p300-HAT Alters Global Gene Expression and Represses HIV Replication

Reversible acetylation of histone and nonhistone proteins plays pivotal role in cellular homeostasis. Dysfunction of histone acetyltransferases (HATs) leads to several diseases including cancer, neurodegenaration, asthma, diabetes, AIDS, and cardiac hypertrophy. We describe the synthesis and charact...

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Veröffentlicht in:	Chemistry & biology 2007-06, Vol.14 (6), p.645-657
Hauptverfasser:	Mantelingu, K., Reddy, B.A. Ashok, Swaminathan, V., Kishore, A. Hari, Siddappa, Nagadenahalli B., Kumar, G.V. Pavan, Nagashankar, G., Natesh, Nagashayana, Roy, Siddhartha, Sadhale, Parag P., Ranga, Udaykumar, Narayana, Chandrabhas, Kundu, Tapas K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Anti-HIV Agents - chemical synthesis Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - genetics Cell Survival - drug effects CHEMBIOL Chromatin - genetics DNA Down-Regulation Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Gene Expression - drug effects HeLa Cells Histone Acetyltransferases - antagonists & inhibitors Histone Acetyltransferases - genetics Histones - genetics HIV-1 - drug effects HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus Humans Models, Molecular Molecular Structure p300-CBP Transcription Factors T-Lymphocytes - virology Terpenes - chemical synthesis Terpenes - chemistry Terpenes - pharmacology Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription, Genetic Tumor Suppressor Protein p53 - metabolism Up-Regulation Virus Replication - drug effects
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