Changes in the function of the inhibitory neurotransmitter system in the rat brain following subchronic inhalation exposure to 1-bromopropane
1-Bromopropane (1-BP) has been widely used as a cleaning agent and a solvent in industries, but the central neurotoxicity of 1-BP remains to be clarified. In the present study, we investigated the effects of subchronic inhalation exposure to 1-BP vapor on the function of the inhibitory neurotransmit...
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| Veröffentlicht in: | Neurotoxicology (Park Forest South) 2007-03, Vol.28 (2), p.415-420 |
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| creator | Ueno, Susumu Yoshida, Yasuhiro Fueta, Yukiko Ishidao, Toru Liu, Jiqin Kunugita, Naoki Yanagihara, Nobuyuki Hori, Hajime |
| description | 1-Bromopropane (1-BP) has been widely used as a cleaning agent and a solvent in industries, but the central neurotoxicity of 1-BP remains to be clarified. In the present study, we investigated the effects of subchronic inhalation exposure to 1-BP vapor on the function of the inhibitory neurotransmitter system mediated by γ-aminobutyric acid (GABA) in the rat brain. Male Wistar rats were exposed to 1-BP vapor for 12 weeks (6
h/day, 5 days/week) at a concentration of 400
ppm, and, in order to investigate the expression and function of brain GABA type A (GABA
A) receptors, total/messenger RNA was prepared from the neocortex, hippocampus, and cerebellum of the control and 1-BP-exposed rats. Moreover, hippocampal slices were prepared, and the population spike (PS) amplitude and the slope of the field excitatory postsynaptic potential (fEPSP) were investigated in the paired-pulse configuration of the extracellular recording technique. Using the
Xenopus oocyte expression system, we compared GABA concentration–response curves obtained from oocytes injected with brain subregional mRNAs of control and 1-BP exposed rats, and observed no significant differences in apparent GABA affinity. On the other hand, paired-pulse inhibition of PS amplitude was significantly decreased in the hippocampal dentate gyrus (DG) by exposure to 1-BP, without any effect on the paired-pulse ratio of the fEPSP slopes, suggesting neuronal disinhibition in the DG. Moreover, RT-PCR analysis indicated decreased levels of GABA
A receptor β3 and δ subunit mRNAs in the hippocampus of 1-BP-exposed rats. These results demonstrate that subchronic inhalation exposure to 1-BP vapor reduces the function of the hippocampal GABAergic system, which could be due to changes in the expression and function of GABA
A receptors, especially the δ subunit-containing GABA
A receptors. |
| doi_str_mv | 10.1016/j.neuro.2006.03.006 |
| format | Article |
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h/day, 5 days/week) at a concentration of 400
ppm, and, in order to investigate the expression and function of brain GABA type A (GABA
A) receptors, total/messenger RNA was prepared from the neocortex, hippocampus, and cerebellum of the control and 1-BP-exposed rats. Moreover, hippocampal slices were prepared, and the population spike (PS) amplitude and the slope of the field excitatory postsynaptic potential (fEPSP) were investigated in the paired-pulse configuration of the extracellular recording technique. Using the
Xenopus oocyte expression system, we compared GABA concentration–response curves obtained from oocytes injected with brain subregional mRNAs of control and 1-BP exposed rats, and observed no significant differences in apparent GABA affinity. On the other hand, paired-pulse inhibition of PS amplitude was significantly decreased in the hippocampal dentate gyrus (DG) by exposure to 1-BP, without any effect on the paired-pulse ratio of the fEPSP slopes, suggesting neuronal disinhibition in the DG. Moreover, RT-PCR analysis indicated decreased levels of GABA
A receptor β3 and δ subunit mRNAs in the hippocampus of 1-BP-exposed rats. These results demonstrate that subchronic inhalation exposure to 1-BP vapor reduces the function of the hippocampal GABAergic system, which could be due to changes in the expression and function of GABA
A receptors, especially the δ subunit-containing GABA
A receptors.</description><identifier>ISSN: 0161-813X</identifier><identifier>EISSN: 1872-9711</identifier><identifier>DOI: 10.1016/j.neuro.2006.03.006</identifier><identifier>PMID: 16647755</identifier><language>eng</language><publisher>Orlando, FL: Elsevier B.V</publisher><subject>1-Bromopropane ; Animals ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Cerebellum - drug effects ; Cerebellum - metabolism ; Disinhibition ; Dose-Response Relationship, Drug ; Excitatory Postsynaptic Potentials - drug effects ; GABA A receptor ; gamma-Aminobutyric Acid - metabolism ; gamma-Aminobutyric Acid - pharmacology ; Gene Expression - drug effects ; Hippocampus - drug effects ; Hippocampus - metabolism ; Hydrocarbons, Brominated - chemistry ; Hydrocarbons, Brominated - toxicity ; Inhalation Exposure ; Male ; Medical sciences ; Microinjections ; Neocortex - drug effects ; Neocortex - metabolism ; Neural Inhibition - drug effects ; Neurotransmitter Agents - metabolism ; Neurotransmitter Agents - pharmacology ; Oocytes ; Rats ; Rats, Wistar ; Receptors, GABA-A - drug effects ; Receptors, GABA-A - genetics ; Receptors, GABA-A - metabolism ; RNA, Messenger - metabolism ; Solvents - chemistry ; Solvents - toxicity ; Toxicology ; Volatilization ; Xenopus ; Xenopus laevis ; Xenopus oocytes ; δ Subunit</subject><ispartof>Neurotoxicology (Park Forest South), 2007-03, Vol.28 (2), p.415-420</ispartof><rights>2006 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-98657c3cad773293897364ad65557ef197ddeb40d9a59d45d82b2a2a852b81be3</citedby><cites>FETCH-LOGICAL-c484t-98657c3cad773293897364ad65557ef197ddeb40d9a59d45d82b2a2a852b81be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuro.2006.03.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3548,23928,23929,25138,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18929718$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16647755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ueno, Susumu</creatorcontrib><creatorcontrib>Yoshida, Yasuhiro</creatorcontrib><creatorcontrib>Fueta, Yukiko</creatorcontrib><creatorcontrib>Ishidao, Toru</creatorcontrib><creatorcontrib>Liu, Jiqin</creatorcontrib><creatorcontrib>Kunugita, Naoki</creatorcontrib><creatorcontrib>Yanagihara, Nobuyuki</creatorcontrib><creatorcontrib>Hori, Hajime</creatorcontrib><title>Changes in the function of the inhibitory neurotransmitter system in the rat brain following subchronic inhalation exposure to 1-bromopropane</title><title>Neurotoxicology (Park Forest South)</title><addtitle>Neurotoxicology</addtitle><description>1-Bromopropane (1-BP) has been widely used as a cleaning agent and a solvent in industries, but the central neurotoxicity of 1-BP remains to be clarified. In the present study, we investigated the effects of subchronic inhalation exposure to 1-BP vapor on the function of the inhibitory neurotransmitter system mediated by γ-aminobutyric acid (GABA) in the rat brain. Male Wistar rats were exposed to 1-BP vapor for 12 weeks (6
h/day, 5 days/week) at a concentration of 400
ppm, and, in order to investigate the expression and function of brain GABA type A (GABA
A) receptors, total/messenger RNA was prepared from the neocortex, hippocampus, and cerebellum of the control and 1-BP-exposed rats. Moreover, hippocampal slices were prepared, and the population spike (PS) amplitude and the slope of the field excitatory postsynaptic potential (fEPSP) were investigated in the paired-pulse configuration of the extracellular recording technique. Using the
Xenopus oocyte expression system, we compared GABA concentration–response curves obtained from oocytes injected with brain subregional mRNAs of control and 1-BP exposed rats, and observed no significant differences in apparent GABA affinity. On the other hand, paired-pulse inhibition of PS amplitude was significantly decreased in the hippocampal dentate gyrus (DG) by exposure to 1-BP, without any effect on the paired-pulse ratio of the fEPSP slopes, suggesting neuronal disinhibition in the DG. Moreover, RT-PCR analysis indicated decreased levels of GABA
A receptor β3 and δ subunit mRNAs in the hippocampus of 1-BP-exposed rats. These results demonstrate that subchronic inhalation exposure to 1-BP vapor reduces the function of the hippocampal GABAergic system, which could be due to changes in the expression and function of GABA
A receptors, especially the δ subunit-containing GABA
A receptors.</description><subject>1-Bromopropane</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Cerebellum - drug effects</subject><subject>Cerebellum - metabolism</subject><subject>Disinhibition</subject><subject>Dose-Response Relationship, Drug</subject><subject>Excitatory Postsynaptic Potentials - drug effects</subject><subject>GABA A receptor</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>gamma-Aminobutyric Acid - pharmacology</subject><subject>Gene Expression - drug effects</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Hydrocarbons, Brominated - chemistry</subject><subject>Hydrocarbons, Brominated - toxicity</subject><subject>Inhalation Exposure</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microinjections</subject><subject>Neocortex - drug effects</subject><subject>Neocortex - metabolism</subject><subject>Neural Inhibition - drug effects</subject><subject>Neurotransmitter Agents - metabolism</subject><subject>Neurotransmitter Agents - pharmacology</subject><subject>Oocytes</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, GABA-A - drug effects</subject><subject>Receptors, GABA-A - genetics</subject><subject>Receptors, GABA-A - metabolism</subject><subject>RNA, Messenger - metabolism</subject><subject>Solvents - chemistry</subject><subject>Solvents - toxicity</subject><subject>Toxicology</subject><subject>Volatilization</subject><subject>Xenopus</subject><subject>Xenopus laevis</subject><subject>Xenopus oocytes</subject><subject>δ Subunit</subject><issn>0161-813X</issn><issn>1872-9711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EotPCEyAhb2CXYCdxbC9YoBEUpErdtBI7y7FvOh4l9mA7hXkI3rmeH9Qdq6Mrffecq3MRekdJTQntP21rD0sMdUNIX5O2LvICrajgTSU5pS_RqlC0ErT9eYEuU9oSQhnv5Wt0Qfu-45yxFfq73mj_AAk7j_MG8Lh4k13wOIzH2fmNG1wOcY-PaTlqn2aXM0Sc9inD_G8z6oyHqMs0hmkKv51_wGkZzCYG78zBSE_6aA1_diEtEXAOmFZDDHPYxbDTHt6gV6OeErw96xW6__b1bv29urm9_rH-clOZTnS5kqJn3LRGW87bRrZC8rbvtO0ZYxxGKrm1MHTESs2k7ZgVzdDoRgvWDIIO0F6hjyffkvtrgZTV7JKBaSo3hCUpKgVnJaSA7Qk0MaQUYVS76GYd94oSdfiC2qpjL-rwBUVaVaRsvT_bL8MM9nnnXHsBPpwBnYyexlKqcemZE7IpLxSF-3zioJTx6CCqZBx4A9ZFMFnZ4P57yBPj16qJ</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Ueno, Susumu</creator><creator>Yoshida, Yasuhiro</creator><creator>Fueta, Yukiko</creator><creator>Ishidao, Toru</creator><creator>Liu, Jiqin</creator><creator>Kunugita, Naoki</creator><creator>Yanagihara, Nobuyuki</creator><creator>Hori, Hajime</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20070301</creationdate><title>Changes in the function of the inhibitory neurotransmitter system in the rat brain following subchronic inhalation exposure to 1-bromopropane</title><author>Ueno, Susumu ; Yoshida, Yasuhiro ; Fueta, Yukiko ; Ishidao, Toru ; Liu, Jiqin ; Kunugita, Naoki ; Yanagihara, Nobuyuki ; Hori, Hajime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-98657c3cad773293897364ad65557ef197ddeb40d9a59d45d82b2a2a852b81be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>1-Bromopropane</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Cerebellum - drug effects</topic><topic>Cerebellum - metabolism</topic><topic>Disinhibition</topic><topic>Dose-Response Relationship, Drug</topic><topic>Excitatory Postsynaptic Potentials - drug effects</topic><topic>GABA A receptor</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>gamma-Aminobutyric Acid - pharmacology</topic><topic>Gene Expression - drug effects</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Hydrocarbons, Brominated - chemistry</topic><topic>Hydrocarbons, Brominated - toxicity</topic><topic>Inhalation Exposure</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microinjections</topic><topic>Neocortex - drug effects</topic><topic>Neocortex - metabolism</topic><topic>Neural Inhibition - drug effects</topic><topic>Neurotransmitter Agents - metabolism</topic><topic>Neurotransmitter Agents - pharmacology</topic><topic>Oocytes</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, GABA-A - drug effects</topic><topic>Receptors, GABA-A - genetics</topic><topic>Receptors, GABA-A - metabolism</topic><topic>RNA, Messenger - metabolism</topic><topic>Solvents - chemistry</topic><topic>Solvents - toxicity</topic><topic>Toxicology</topic><topic>Volatilization</topic><topic>Xenopus</topic><topic>Xenopus laevis</topic><topic>Xenopus oocytes</topic><topic>δ Subunit</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ueno, Susumu</creatorcontrib><creatorcontrib>Yoshida, Yasuhiro</creatorcontrib><creatorcontrib>Fueta, Yukiko</creatorcontrib><creatorcontrib>Ishidao, Toru</creatorcontrib><creatorcontrib>Liu, Jiqin</creatorcontrib><creatorcontrib>Kunugita, Naoki</creatorcontrib><creatorcontrib>Yanagihara, Nobuyuki</creatorcontrib><creatorcontrib>Hori, Hajime</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Neurotoxicology (Park Forest South)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ueno, Susumu</au><au>Yoshida, Yasuhiro</au><au>Fueta, Yukiko</au><au>Ishidao, Toru</au><au>Liu, Jiqin</au><au>Kunugita, Naoki</au><au>Yanagihara, Nobuyuki</au><au>Hori, Hajime</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in the function of the inhibitory neurotransmitter system in the rat brain following subchronic inhalation exposure to 1-bromopropane</atitle><jtitle>Neurotoxicology (Park Forest South)</jtitle><addtitle>Neurotoxicology</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>28</volume><issue>2</issue><spage>415</spage><epage>420</epage><pages>415-420</pages><issn>0161-813X</issn><eissn>1872-9711</eissn><abstract>1-Bromopropane (1-BP) has been widely used as a cleaning agent and a solvent in industries, but the central neurotoxicity of 1-BP remains to be clarified. In the present study, we investigated the effects of subchronic inhalation exposure to 1-BP vapor on the function of the inhibitory neurotransmitter system mediated by γ-aminobutyric acid (GABA) in the rat brain. Male Wistar rats were exposed to 1-BP vapor for 12 weeks (6
h/day, 5 days/week) at a concentration of 400
ppm, and, in order to investigate the expression and function of brain GABA type A (GABA
A) receptors, total/messenger RNA was prepared from the neocortex, hippocampus, and cerebellum of the control and 1-BP-exposed rats. Moreover, hippocampal slices were prepared, and the population spike (PS) amplitude and the slope of the field excitatory postsynaptic potential (fEPSP) were investigated in the paired-pulse configuration of the extracellular recording technique. Using the
Xenopus oocyte expression system, we compared GABA concentration–response curves obtained from oocytes injected with brain subregional mRNAs of control and 1-BP exposed rats, and observed no significant differences in apparent GABA affinity. On the other hand, paired-pulse inhibition of PS amplitude was significantly decreased in the hippocampal dentate gyrus (DG) by exposure to 1-BP, without any effect on the paired-pulse ratio of the fEPSP slopes, suggesting neuronal disinhibition in the DG. Moreover, RT-PCR analysis indicated decreased levels of GABA
A receptor β3 and δ subunit mRNAs in the hippocampus of 1-BP-exposed rats. These results demonstrate that subchronic inhalation exposure to 1-BP vapor reduces the function of the hippocampal GABAergic system, which could be due to changes in the expression and function of GABA
A receptors, especially the δ subunit-containing GABA
A receptors.</abstract><cop>Orlando, FL</cop><pub>Elsevier B.V</pub><pmid>16647755</pmid><doi>10.1016/j.neuro.2006.03.006</doi><tpages>6</tpages></addata></record> |
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| ispartof | Neurotoxicology (Park Forest South), 2007-03, Vol.28 (2), p.415-420 |
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| language | eng |
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| subjects | 1-Bromopropane Animals Biological and medical sciences Brain - drug effects Brain - metabolism Cerebellum - drug effects Cerebellum - metabolism Disinhibition Dose-Response Relationship, Drug Excitatory Postsynaptic Potentials - drug effects GABA A receptor gamma-Aminobutyric Acid - metabolism gamma-Aminobutyric Acid - pharmacology Gene Expression - drug effects Hippocampus - drug effects Hippocampus - metabolism Hydrocarbons, Brominated - chemistry Hydrocarbons, Brominated - toxicity Inhalation Exposure Male Medical sciences Microinjections Neocortex - drug effects Neocortex - metabolism Neural Inhibition - drug effects Neurotransmitter Agents - metabolism Neurotransmitter Agents - pharmacology Oocytes Rats Rats, Wistar Receptors, GABA-A - drug effects Receptors, GABA-A - genetics Receptors, GABA-A - metabolism RNA, Messenger - metabolism Solvents - chemistry Solvents - toxicity Toxicology Volatilization Xenopus Xenopus laevis Xenopus oocytes δ Subunit |
| title | Changes in the function of the inhibitory neurotransmitter system in the rat brain following subchronic inhalation exposure to 1-bromopropane |
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