Estrogen Selectively Increases Tryptophan Hydroxylase-2 mRNA Expression in Distinct Subregions of Rat Midbrain Raphe Nucleus: Association between Gene Expression and Anxiety Behavior in the Open Field

Ovarian steroids modulate anxiety behavior, perhaps by regulating the serotonergic neurons in the midbrain raphe nucleus. The regulation of the brain-specific isoform of rat tryptophan hydroxylase (TPH2) by ovarian hormones has not yet been investigated. Therefore, we examined the effects of estroge...

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Veröffentlicht in:	Biological psychiatry (1969) 2006-08, Vol.60 (3), p.288-295
Hauptverfasser:	Hiroi, Ryoko, McDevitt, Ross A., Neumaier, John F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety - genetics Anxiety - metabolism Behavior, Animal Behavioral psychophysiology Biological and medical sciences Densitometry - methods dorsal raphe Estrogens - pharmacology Female Fundamental and applied biological sciences. Psychology Gene Expression - genetics Gene Expression - physiology Immunohistochemistry - methods In Situ Hybridization - methods median raphe Miscellaneous Ovarian hormones Ovariectomy progesterone Progesterone - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Raphe Nuclei - drug effects Raphe Nuclei - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - biosynthesis RNA, Messenger - genetics serotonin Spatial Behavior TPH2 Tryptophan Hydroxylase - biosynthesis Tryptophan Hydroxylase - genetics
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