Anatomically discrete functional effects of adenoviral clostridial light chain gene-based synaptic inhibition in the midbrain

The gene for the Light Chain fragment of Tetanus Toxin (LC) induces synaptic inhibition by preventing the release of synaptic vesicles. The present experiment applied this approach within the rat midbrain in order to demonstrate that LC gene expression can achieve functionally and anatomically discr...

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Veröffentlicht in:	Gene therapy 2006-06, Vol.13 (12), p.942-952
Hauptverfasser:	Zhao, Z, Krishnaney, A, Teng, Q, Yang, J, Garrity-Moses, M, Liu, J K, Venkiteswaran, K, Subramanian, T, Davis, M, Boulis, N M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviruses Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Bacterial toxins Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Blotting, Western - methods Brain Brain diseases Care and treatment Cell Biology Cell physiology Expression vectors Fear Fear conditioning Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Genetic aspects Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - genetics Green fluorescent protein Green Fluorescent Proteins - genetics Health aspects Health. Pharmaceutical industry Human Genetics Immunohistochemistry - methods Industrial applications and implications. Economical aspects Injections, Intraventricular Locomotor activity Male Medical sciences Mesencephalon Mesencephalon - metabolism Metalloendopeptidases - genetics Metalloendopeptidases - metabolism Models, Animal Molecular and cellular biology Nanotechnology Neuromodulation original-article Physiological aspects Potentiation R-SNARE Proteins - genetics R-SNARE Proteins - metabolism Rats Rats, Sprague-Dawley Reflex Rodents Secretion. Exocytosis Startle response Superior colliculus Synaptic vesicles Synaptic Vesicles - metabolism Synaptobrevin Tetanus Tetanus toxin Tetanus Toxin - genetics Tetanus Toxin - metabolism Tonic immobility Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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