Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual
Abstract Evidence is accruing that environmental exposures during critical periods of early development induce persisting changes in skeletal growth, and alter fracture risk in later life. We have previously demonstrated that placental calcium transport, partly determined by maternal 25-(OH) vitamin...
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| Veröffentlicht in: | Bone (New York, N.Y.) N.Y.), 2007-05, Vol.40 (5), p.1203-1208 |
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| creator | Martin, R Harvey, N.C Crozier, S.R Poole, J.R Javaid, M.K Dennison, E.M Inskip, H.M Hanson, M Godfrey, K.M Cooper, C Lewis, R |
| description | Abstract Evidence is accruing that environmental exposures during critical periods of early development induce persisting changes in skeletal growth, and alter fracture risk in later life. We have previously demonstrated that placental calcium transport, partly determined by maternal 25-(OH) vitamin D status, may underlie this phenomenon. However, the precise relationship between expression of calcium transport proteins in the human placenta, and neonatal bone mineral accrual in the offspring, remains unknown. Tissue samples from 70 human placentae were fast frozen in liquid nitrogen and stored at − 70 °C. A quantitative real time reverse transcriptase polymerase chain reaction was used to measure the mRNA expression of PMCA isoforms 1–4, using beta-actin as a control gene. Neonatal whole body bone area, mineral content and areal density (BA, BMC, BMD) were measured within 2 weeks of birth using DXA. PMCA3 mRNA expression predicted BA ( r = 0.28, p = 0.02), BMC ( r = 0.25, p = 0.04), placental weight ( r = 0.26, p = 0.04) and birth weight ( r = 0.33, p = 0.006) of the neonate. In a multivariate model, the relationship between placental PMCA3 expression and neonatal BMC was independent of maternal height, pre-pregnant fat stores, parity, physical activity, smoking, and calcium intake ( p < 0.05). Expression of the placental calcium transporter PMCA3 mRNA predicts neonatal whole body bone mineral content. This association may explain, in part, the mechanism whereby a mother's 25(OH)-vitamin D stores influence her offspring's bone mass. |
| doi_str_mv | 10.1016/j.bone.2006.12.060 |
| format | Article |
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We have previously demonstrated that placental calcium transport, partly determined by maternal 25-(OH) vitamin D status, may underlie this phenomenon. However, the precise relationship between expression of calcium transport proteins in the human placenta, and neonatal bone mineral accrual in the offspring, remains unknown. Tissue samples from 70 human placentae were fast frozen in liquid nitrogen and stored at − 70 °C. A quantitative real time reverse transcriptase polymerase chain reaction was used to measure the mRNA expression of PMCA isoforms 1–4, using beta-actin as a control gene. Neonatal whole body bone area, mineral content and areal density (BA, BMC, BMD) were measured within 2 weeks of birth using DXA. PMCA3 mRNA expression predicted BA ( r = 0.28, p = 0.02), BMC ( r = 0.25, p = 0.04), placental weight ( r = 0.26, p = 0.04) and birth weight ( r = 0.33, p = 0.006) of the neonate. In a multivariate model, the relationship between placental PMCA3 expression and neonatal BMC was independent of maternal height, pre-pregnant fat stores, parity, physical activity, smoking, and calcium intake ( p < 0.05). Expression of the placental calcium transporter PMCA3 mRNA predicts neonatal whole body bone mineral content. This association may explain, in part, the mechanism whereby a mother's 25(OH)-vitamin D stores influence her offspring's bone mass.</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2006.12.060</identifier><identifier>PMID: 17336174</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Birth Weight ; Body Composition ; Body Height ; Bone Density - physiology ; Calcium transport ; Developmental origins ; Diseases of the osteoarticular system ; Epidemiology ; Female ; Gene Expression Regulation ; Gestational Age ; Humans ; Infant, Newborn ; Injuries of the limb. Injuries of the spine ; Investigative techniques, diagnostic techniques (general aspects) ; Life Style ; Male ; Medical sciences ; Mothers ; Orthopedics ; Osteoarticular system. Muscles ; Osteoporosis ; Osteoporosis. Osteomalacia. Paget disease ; Placenta ; Plasma Membrane Calcium-Transporting ATPases - genetics ; Pregnancy ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; RNA, Messenger - genetics ; Time Factors ; Traumas. Diseases due to physical agents ; Uterus - metabolism</subject><ispartof>Bone (New York, N.Y.), 2007-05, Vol.40 (5), p.1203-1208</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-ece0c80366b04511e7578018c95489d921d23cb5fd9498ad2e28ac26edc899703</citedby><cites>FETCH-LOGICAL-c470t-ece0c80366b04511e7578018c95489d921d23cb5fd9498ad2e28ac26edc899703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S8756328206009501$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18739927$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17336174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martin, R</creatorcontrib><creatorcontrib>Harvey, N.C</creatorcontrib><creatorcontrib>Crozier, S.R</creatorcontrib><creatorcontrib>Poole, J.R</creatorcontrib><creatorcontrib>Javaid, M.K</creatorcontrib><creatorcontrib>Dennison, E.M</creatorcontrib><creatorcontrib>Inskip, H.M</creatorcontrib><creatorcontrib>Hanson, M</creatorcontrib><creatorcontrib>Godfrey, K.M</creatorcontrib><creatorcontrib>Cooper, C</creatorcontrib><creatorcontrib>Lewis, R</creatorcontrib><creatorcontrib>the SWS Study Group</creatorcontrib><creatorcontrib>SWS Study Group</creatorcontrib><title>Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual</title><title>Bone (New York, N.Y.)</title><addtitle>Bone</addtitle><description>Abstract Evidence is accruing that environmental exposures during critical periods of early development induce persisting changes in skeletal growth, and alter fracture risk in later life. We have previously demonstrated that placental calcium transport, partly determined by maternal 25-(OH) vitamin D status, may underlie this phenomenon. However, the precise relationship between expression of calcium transport proteins in the human placenta, and neonatal bone mineral accrual in the offspring, remains unknown. Tissue samples from 70 human placentae were fast frozen in liquid nitrogen and stored at − 70 °C. A quantitative real time reverse transcriptase polymerase chain reaction was used to measure the mRNA expression of PMCA isoforms 1–4, using beta-actin as a control gene. Neonatal whole body bone area, mineral content and areal density (BA, BMC, BMD) were measured within 2 weeks of birth using DXA. PMCA3 mRNA expression predicted BA ( r = 0.28, p = 0.02), BMC ( r = 0.25, p = 0.04), placental weight ( r = 0.26, p = 0.04) and birth weight ( r = 0.33, p = 0.006) of the neonate. In a multivariate model, the relationship between placental PMCA3 expression and neonatal BMC was independent of maternal height, pre-pregnant fat stores, parity, physical activity, smoking, and calcium intake ( p < 0.05). Expression of the placental calcium transporter PMCA3 mRNA predicts neonatal whole body bone mineral content. This association may explain, in part, the mechanism whereby a mother's 25(OH)-vitamin D stores influence her offspring's bone mass.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>Body Composition</subject><subject>Body Height</subject><subject>Bone Density - physiology</subject><subject>Calcium transport</subject><subject>Developmental origins</subject><subject>Diseases of the osteoarticular system</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gene Expression Regulation</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Injuries of the limb. Injuries of the spine</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Life Style</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mothers</subject><subject>Orthopedics</subject><subject>Osteoarticular system. Muscles</subject><subject>Osteoporosis</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Placenta</subject><subject>Plasma Membrane Calcium-Transporting ATPases - genetics</subject><subject>Pregnancy</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>RNA, Messenger - genetics</subject><subject>Time Factors</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Uterus - metabolism</subject><issn>8756-3282</issn><issn>1873-2763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk2LFDEQhoMo7uzqH_AgfVHWQ7f56M4HiLAMfsGKC-o5ZqprJGNPejbpFvffW80MLHjwlDo8b6XypBh7JngjuNCvd81mTNhIznUjZMM1f8BWwhpVS6PVQ7ayptO1klaesfNSdpxz5Yx4zM6EUUoL067Yj5shAKYpDBWEAeK8r6YcUjmMecJcXd58Xl-pV9VPTFjhn0PGUuKYKir6CFOpYiJ8JjQSsIxT7anK1C4A5DkMT9ijbRgKPj2dF-z7-3ff1h_r6y8fPq2vrmtoDZ9qBORgudJ6w9tOCDSdsVxYcF1rXe-k6KWCTbftXets6CVKG0Bq7ME6Z7i6YC-PfQ95vJ2xTH4fC-AwhITjXLxwVjvlBIHyCEIeS8m49Ycc9yHfecH94tXv_PIQv3j1QnrySqHnp-7zZo_9feQkkoAXJyAUErklhxDLPUe_4pw0xL05ckgufkfMvkDEBKQzI0y-H-P_53j7TxyGmCLd-AvvsOzGOSey7IUvFPBflw1YFoCy3HVcqL-eTas-</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Martin, R</creator><creator>Harvey, N.C</creator><creator>Crozier, S.R</creator><creator>Poole, J.R</creator><creator>Javaid, M.K</creator><creator>Dennison, E.M</creator><creator>Inskip, H.M</creator><creator>Hanson, M</creator><creator>Godfrey, K.M</creator><creator>Cooper, C</creator><creator>Lewis, R</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20070501</creationdate><title>Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual</title><author>Martin, R ; Harvey, N.C ; Crozier, S.R ; Poole, J.R ; Javaid, M.K ; Dennison, E.M ; Inskip, H.M ; Hanson, M ; Godfrey, K.M ; Cooper, C ; Lewis, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-ece0c80366b04511e7578018c95489d921d23cb5fd9498ad2e28ac26edc899703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>Body Composition</topic><topic>Body Height</topic><topic>Bone Density - physiology</topic><topic>Calcium transport</topic><topic>Developmental origins</topic><topic>Diseases of the osteoarticular system</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gene Expression Regulation</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Injuries of the limb. Injuries of the spine</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Life Style</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mothers</topic><topic>Orthopedics</topic><topic>Osteoarticular system. Muscles</topic><topic>Osteoporosis</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Placenta</topic><topic>Plasma Membrane Calcium-Transporting ATPases - genetics</topic><topic>Pregnancy</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>RNA, Messenger - genetics</topic><topic>Time Factors</topic><topic>Traumas. 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We have previously demonstrated that placental calcium transport, partly determined by maternal 25-(OH) vitamin D status, may underlie this phenomenon. However, the precise relationship between expression of calcium transport proteins in the human placenta, and neonatal bone mineral accrual in the offspring, remains unknown. Tissue samples from 70 human placentae were fast frozen in liquid nitrogen and stored at − 70 °C. A quantitative real time reverse transcriptase polymerase chain reaction was used to measure the mRNA expression of PMCA isoforms 1–4, using beta-actin as a control gene. Neonatal whole body bone area, mineral content and areal density (BA, BMC, BMD) were measured within 2 weeks of birth using DXA. PMCA3 mRNA expression predicted BA ( r = 0.28, p = 0.02), BMC ( r = 0.25, p = 0.04), placental weight ( r = 0.26, p = 0.04) and birth weight ( r = 0.33, p = 0.006) of the neonate. In a multivariate model, the relationship between placental PMCA3 expression and neonatal BMC was independent of maternal height, pre-pregnant fat stores, parity, physical activity, smoking, and calcium intake ( p < 0.05). Expression of the placental calcium transporter PMCA3 mRNA predicts neonatal whole body bone mineral content. This association may explain, in part, the mechanism whereby a mother's 25(OH)-vitamin D stores influence her offspring's bone mass.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17336174</pmid><doi>10.1016/j.bone.2006.12.060</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Birth Weight Body Composition Body Height Bone Density - physiology Calcium transport Developmental origins Diseases of the osteoarticular system Epidemiology Female Gene Expression Regulation Gestational Age Humans Infant, Newborn Injuries of the limb. Injuries of the spine Investigative techniques, diagnostic techniques (general aspects) Life Style Male Medical sciences Mothers Orthopedics Osteoarticular system. Muscles Osteoporosis Osteoporosis. Osteomalacia. Paget disease Placenta Plasma Membrane Calcium-Transporting ATPases - genetics Pregnancy Radiodiagnosis. Nmr imagery. Nmr spectrometry RNA, Messenger - genetics Time Factors Traumas. Diseases due to physical agents Uterus - metabolism |
| title | Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual |
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