Glucose-induced production of recombinant proteins in Hansenula polymorpha mutants deficient in catabolite repression

The most commonly used expression platform for production of recombinant proteins in the methylotrophic yeast Hansenula polymorpha relies on the strong and strictly regulated promoter from the gene encoding peroxisomal enzyme alcohol (or methanol) oxidase (P(MOX)). Expression from P(MOX) is induced...

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Veröffentlicht in:	Biotechnology and bioengineering 2007-07, Vol.97 (4), p.858-870
Hauptverfasser:	KRASOVSKA, Olena S, STASYK, Olena G, NAHORNY, Viktor O, STASYK, Oleh V, GRANOVSKI, Nikolai, KORDIMU, Vitaliy A, VOZIANOV, Oleksandr F, SIBIMYL, Andriy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - genetics Aspergillus niger Biological and medical sciences Biotechnology Disaccharides - deficiency Ethanol - metabolism Fundamental and applied biological sciences. Psychology Glucose - pharmacology Hansenula polymorpha Hepatitis B virus Mutation Pichia - enzymology Pichia - genetics Promoter Regions, Genetic Recombinant Proteins - biosynthesis
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