alpha-Synuclein fission yeast model: concentration-dependent aggregation without plasma membrane localization or toxicity

Despite fission yeast's history of modeling salient cellular processes, it has not yet been used to model human neurodegeneration-linked protein misfolding. Because alpha-synuclein misfolding and aggregation are linked to Parkinson's disease (PD), here, we report a fission yeast (Schizosac...

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Veröffentlicht in:	Journal of molecular neuroscience 2006-01, Vol.28 (2), p.179-192
Hauptverfasser:	Brandis, Katrina A, Holmes, Isaac F, England, Samantha J, Sharma, Nijee, Kukreja, Lokesh, DebBurman, Shubhik K
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry alpha-Synuclein - genetics alpha-Synuclein - metabolism alpha-Synuclein - toxicity Animals Cell Membrane - metabolism Humans Mutation Oxidative Stress Parkinson Disease - physiopathology Promoter Regions, Genetic Proteasome Endopeptidase Complex - metabolism Protein Folding Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - physiology Schizosaccharomyces - cytology Schizosaccharomyces - physiology Schizosaccharomyces pombe
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