Reduced expression of the Connexin26 gene and its aberrant DNA methylation in rat lung adenocarcinomas induced by N-nitrosobis(2-Hydroxypropyl)amine

Gap junctions are mediated by intercellular channels that connect adjacent cells and are composed of Connexin (Cx) proteins. A member of the Cx family, Cx26 is considered a potential tumor suppressor in several cancers. The expression of Cx26 gene and its methylation status in rat lung adenocarcinom...

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Veröffentlicht in:	Molecular carcinogenesis 2006-09, Vol.45 (9), p.710-714
Hauptverfasser:	Shimizu, Kyoko, Shimoichi, Yozo, Hinotsume, Daisei, Itsuzaki, Yumi, Fujii, Hiromasa, Honoki, Kanya, Tsujiuchi, Toshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - chemically induced Adenocarcinoma - genetics Animals Carcinoma, Non-Small-Cell Lung - chemically induced Carcinoma, Non-Small-Cell Lung - genetics Connexin 26 Connexin26 Connexins - genetics DNA Methylation Gene Expression Regulation, Neoplastic lung adenocarcinoma Lung Neoplasms - chemically induced Lung Neoplasms - genetics Male Nitrosamines - toxicity rat Rats Rats, Wistar
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