Molecular Mechanisms of Hepatocarcinogenesis in Transgenic Mouse Models of Liver Cancer

Overexpression of c-myc and transforming growth factor-alpha (TGF-α) has been frequently observed in human hepatocellular carcinoma (HCC), suggesting a pivotal role played by these protooncogenes in liver oncogenesis. In order to investigate the molecular events underlying human hepatic malignant tr...

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Veröffentlicht in:	Toxicologic pathology 2005-01, Vol.33 (1), p.181-184
Hauptverfasser:	Calvisi, Diego F., Thorgeirsson, Snorri S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Liver Neoplasms, Experimental - etiology Medical sciences Mice Mice, Transgenic Models, Genetic Molecular Biology Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Toxicology Transforming Growth Factor alpha - genetics Transforming Growth Factor alpha - metabolism Transgenes
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