Ntg1p, the base excision repair protein, generates mutagenic intermediates in yeast mitochondrial DNA

Mitochondrial DNA is predicted to be highly prone to oxidative damage due to its proximity to free radicals generated by oxidative phosphorylation. Base excision repair (BER) is the primary repair pathway responsible for repairing oxidative damage in nuclear and mitochondrial genomes. In yeast mitoc...

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Veröffentlicht in:	DNA repair 2006-07, Vol.5 (7), p.829-839
Hauptverfasser:	Phadnis, Naina, Mehta, Reema, Meednu, Nida, Sia, Elaine A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base excision repair Base Sequence DNA Glycosylases - genetics DNA Glycosylases - metabolism DNA Repair DNA Repair Enzymes DNA, Fungal - genetics DNA, Fungal - metabolism DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism DNA-(Apurinic or Apyrimidinic Site) Lyase Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Frameshift Mutation Gene Expression Genome, Fungal Mitochondria Models, Biological Mutagenic intermediates Mutation N-Glycosyl Hydrolases - genetics N-Glycosyl Hydrolases - metabolism Ntg1p Oxygen - metabolism Point Mutation Recombination, Genetic Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - radiation effects Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Ultraviolet Rays
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