Basic Fibroblast Growth Factor Protects Astrocytes Against Ischemia/Reperfusion Injury by Upregulating the Caveolin-1/VEGF Signaling Pathway

A previous in vivo study demonstrated that intracerebroventricular injection of basic fibroblast growth factor (bFGF) in middle cerebral artery occlusion rats increased the expression of caveolin-1 (cav-1) and vascular endothelial growth factor (VEGF) in cerebral ischemia penumbra. Because astrocyte...

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Veröffentlicht in:	Journal of molecular neuroscience 2018-02, Vol.64 (2), p.211-223
Hauptverfasser:	Liu, Meixia, Wu, Yudan, Liu, Yidian, Chen, Zhenzhen, He, Shujuan, Zhang, Huimei, Wu, Liang, Tu, Fengxia, Zhao, Yun, Liu, Chan, Chen, Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Astrocytes - drug effects Astrocytes - metabolism Biomedical and Life Sciences Biomedicine Brain Brain Ischemia - metabolism Caveolin Caveolin 1 - metabolism Caveolin-1 Cell Biology Cell survival Cells, Cultured Cerebral blood flow Cholecystokinin Deprivation Female Fibroblast growth factor 2 Fibroblast Growth Factor 2 - pharmacology Fibroblasts Gene expression Glucose Glucose - deficiency Immunofluorescence In vivo methods and tests Inhibitors Ischemia Male Neurochemistry Neurology Neuroprotective Agents - pharmacology Neurosciences Occlusion Oxygen Oxygen - metabolism Polymerase chain reaction Proteins Proteomics Rats Rats, Sprague-Dawley Reperfusion Reperfusion Injury - metabolism Reverse transcription Rodents Signal Transduction Signaling siRNA Up-Regulation Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Western blotting
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