Ultrastructural Features of Alkhumra Hemorrhagic Fever Virus Infection of Cells Under In Vivo and In Vitro Conditions
Alkhumra hemorrhagic fever virus (AHFV) is an emerging novel flavivirus that was discovered in Saudi Arabia in 1995. The virus has since caused several outbreaks in the country that resulted in case fatality rates ranging from 1% to 25%. Meager information has been published on the ultrastructural f...
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| Veröffentlicht in: | Vector borne and zoonotic diseases (Larchmont, N.Y.) N.Y.), 2018-02, Vol.18 (2), p.18-113 |
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| container_title | Vector borne and zoonotic diseases (Larchmont, N.Y.) |
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| creator | Madani, Tariq A. Abuelzein, El-Tayb M.E. Abu-Araki, Huda Ali, Soad S. Jalalah, Sawsan M. Hassan, Ahmed M. Al-Bar, Hussein M.S. Azhar, Esam I. |
| description | Alkhumra hemorrhagic fever virus (AHFV) is an emerging novel flavivirus that was discovered in Saudi Arabia in 1995. The virus has since caused several outbreaks in the country that resulted in case fatality rates ranging from 1% to 25%. Meager information has been published on the ultrastructural features of the virus on cells under
in vitro
or
in vivo
conditions. The present electron microscopic study examined and compared the intracellular growth of the AHFV on the LLC-MK2 cells and brain cells of new born Wistar rats, inoculated intracerebrally. The cytopathological changes in both cell systems were noted, and localization of the virus particles in different cellular components was observed. Both apoptotic and lytic cell interactions were seen in the electron micrographs of both the LLC-MK2 and the rat brain cells. The results were discussed in relation to similar situations reported for other virus members of the genus
Flavivirus
. |
| doi_str_mv | 10.1089/vbz.2017.2194 |
| format | Article |
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in vitro
or
in vivo
conditions. The present electron microscopic study examined and compared the intracellular growth of the AHFV on the LLC-MK2 cells and brain cells of new born Wistar rats, inoculated intracerebrally. The cytopathological changes in both cell systems were noted, and localization of the virus particles in different cellular components was observed. Both apoptotic and lytic cell interactions were seen in the electron micrographs of both the LLC-MK2 and the rat brain cells. The results were discussed in relation to similar situations reported for other virus members of the genus
Flavivirus
.</description><identifier>ISSN: 1530-3667</identifier><identifier>EISSN: 1557-7759</identifier><identifier>DOI: 10.1089/vbz.2017.2194</identifier><identifier>PMID: 29298405</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Apoptosis ; Brain ; Cell interactions ; Electron micrographs ; Fever ; Flavivirus ; Hemorrhage ; Hemorrhagic fever ; In vivo methods and tests ; Localization ; Micrography ; Original Articles ; Outbreaks ; Rats ; Rodents ; Viruses</subject><ispartof>Vector borne and zoonotic diseases (Larchmont, N.Y.), 2018-02, Vol.18 (2), p.18-113</ispartof><rights>2018, Mary Ann Liebert, Inc.</rights><rights>(©) Copyright 2018, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-da17b264a8f1c2b029ee6487f4f2e66ed1e4a522c31d19d6653613b5b2bb9d913</citedby><cites>FETCH-LOGICAL-c365t-da17b264a8f1c2b029ee6487f4f2e66ed1e4a522c31d19d6653613b5b2bb9d913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29298405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Madani, Tariq A.</creatorcontrib><creatorcontrib>Abuelzein, El-Tayb M.E.</creatorcontrib><creatorcontrib>Abu-Araki, Huda</creatorcontrib><creatorcontrib>Ali, Soad S.</creatorcontrib><creatorcontrib>Jalalah, Sawsan M.</creatorcontrib><creatorcontrib>Hassan, Ahmed M.</creatorcontrib><creatorcontrib>Al-Bar, Hussein M.S.</creatorcontrib><creatorcontrib>Azhar, Esam I.</creatorcontrib><title>Ultrastructural Features of Alkhumra Hemorrhagic Fever Virus Infection of Cells Under In Vivo and In Vitro Conditions</title><title>Vector borne and zoonotic diseases (Larchmont, N.Y.)</title><addtitle>Vector Borne Zoonotic Dis</addtitle><description>Alkhumra hemorrhagic fever virus (AHFV) is an emerging novel flavivirus that was discovered in Saudi Arabia in 1995. The virus has since caused several outbreaks in the country that resulted in case fatality rates ranging from 1% to 25%. Meager information has been published on the ultrastructural features of the virus on cells under
in vitro
or
in vivo
conditions. The present electron microscopic study examined and compared the intracellular growth of the AHFV on the LLC-MK2 cells and brain cells of new born Wistar rats, inoculated intracerebrally. The cytopathological changes in both cell systems were noted, and localization of the virus particles in different cellular components was observed. Both apoptotic and lytic cell interactions were seen in the electron micrographs of both the LLC-MK2 and the rat brain cells. The results were discussed in relation to similar situations reported for other virus members of the genus
Flavivirus
.</description><subject>Apoptosis</subject><subject>Brain</subject><subject>Cell interactions</subject><subject>Electron micrographs</subject><subject>Fever</subject><subject>Flavivirus</subject><subject>Hemorrhage</subject><subject>Hemorrhagic fever</subject><subject>In vivo methods and tests</subject><subject>Localization</subject><subject>Micrography</subject><subject>Original Articles</subject><subject>Outbreaks</subject><subject>Rats</subject><subject>Rodents</subject><subject>Viruses</subject><issn>1530-3667</issn><issn>1557-7759</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqF0c9v2yAUB3BUrWqytMdeJ6RddnHKD4PNMYraJVKlXZpeLTDPq1sbMjCRtr9-WOl22GUHxBN8eHrii9AtJWtKanV3Mr_WjNBqzagqL9CSClEVVSXUh7nmpOBSVgv0McZXQhitqbhCC6aYqksiligdhinoOIXUTinoAT-AzgVE7Du8Gd5e0hg03sHoQ3jR3_s2gxME_NyHFPHeddBOvXez3sIwRHxwNl_vXRYnj7Wz53oKHm-9s_2s4zW67PQQ4eZ9X6HDw_3Tdlc8fvu6324ei5ZLMRVW08owWeq6oy0zhCkAWdZVV3YMpARLodSCsZZTS5WVUnBJuRGGGaOsonyFvpz7HoP_kSBOzdjHNs-pHfgUG5p_ocqP8lqhz__QV5-Cy9NlpRjPAwmeVXFWbfAxBuiaY-hHHX42lDRzHk3Oo5nzaOY8sv_03jWZEexf_SeADPgZzMfauaEHA2H6T9vfyRiXqQ</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Madani, Tariq A.</creator><creator>Abuelzein, El-Tayb M.E.</creator><creator>Abu-Araki, Huda</creator><creator>Ali, Soad S.</creator><creator>Jalalah, Sawsan M.</creator><creator>Hassan, Ahmed M.</creator><creator>Al-Bar, Hussein M.S.</creator><creator>Azhar, Esam I.</creator><general>Mary Ann Liebert, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7SS</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20180201</creationdate><title>Ultrastructural Features of Alkhumra Hemorrhagic Fever Virus Infection of Cells Under In Vivo and In Vitro Conditions</title><author>Madani, Tariq A. ; Abuelzein, El-Tayb M.E. ; Abu-Araki, Huda ; Ali, Soad S. ; Jalalah, Sawsan M. ; Hassan, Ahmed M. ; Al-Bar, Hussein M.S. ; Azhar, Esam I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-da17b264a8f1c2b029ee6487f4f2e66ed1e4a522c31d19d6653613b5b2bb9d913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Apoptosis</topic><topic>Brain</topic><topic>Cell interactions</topic><topic>Electron micrographs</topic><topic>Fever</topic><topic>Flavivirus</topic><topic>Hemorrhage</topic><topic>Hemorrhagic fever</topic><topic>In vivo methods and tests</topic><topic>Localization</topic><topic>Micrography</topic><topic>Original Articles</topic><topic>Outbreaks</topic><topic>Rats</topic><topic>Rodents</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Madani, Tariq A.</creatorcontrib><creatorcontrib>Abuelzein, El-Tayb M.E.</creatorcontrib><creatorcontrib>Abu-Araki, Huda</creatorcontrib><creatorcontrib>Ali, Soad S.</creatorcontrib><creatorcontrib>Jalalah, Sawsan M.</creatorcontrib><creatorcontrib>Hassan, Ahmed M.</creatorcontrib><creatorcontrib>Al-Bar, Hussein M.S.</creatorcontrib><creatorcontrib>Azhar, Esam I.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Vector borne and zoonotic diseases (Larchmont, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Madani, Tariq A.</au><au>Abuelzein, El-Tayb M.E.</au><au>Abu-Araki, Huda</au><au>Ali, Soad S.</au><au>Jalalah, Sawsan M.</au><au>Hassan, Ahmed M.</au><au>Al-Bar, Hussein M.S.</au><au>Azhar, Esam I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrastructural Features of Alkhumra Hemorrhagic Fever Virus Infection of Cells Under In Vivo and In Vitro Conditions</atitle><jtitle>Vector borne and zoonotic diseases (Larchmont, N.Y.)</jtitle><addtitle>Vector Borne Zoonotic Dis</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>18</volume><issue>2</issue><spage>18</spage><epage>113</epage><pages>18-113</pages><issn>1530-3667</issn><eissn>1557-7759</eissn><abstract>Alkhumra hemorrhagic fever virus (AHFV) is an emerging novel flavivirus that was discovered in Saudi Arabia in 1995. The virus has since caused several outbreaks in the country that resulted in case fatality rates ranging from 1% to 25%. Meager information has been published on the ultrastructural features of the virus on cells under
in vitro
or
in vivo
conditions. The present electron microscopic study examined and compared the intracellular growth of the AHFV on the LLC-MK2 cells and brain cells of new born Wistar rats, inoculated intracerebrally. The cytopathological changes in both cell systems were noted, and localization of the virus particles in different cellular components was observed. Both apoptotic and lytic cell interactions were seen in the electron micrographs of both the LLC-MK2 and the rat brain cells. The results were discussed in relation to similar situations reported for other virus members of the genus
Flavivirus
.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>29298405</pmid><doi>10.1089/vbz.2017.2194</doi><tpages>96</tpages></addata></record> |
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| source | Alma/SFX Local Collection |
| subjects | Apoptosis Brain Cell interactions Electron micrographs Fever Flavivirus Hemorrhage Hemorrhagic fever In vivo methods and tests Localization Micrography Original Articles Outbreaks Rats Rodents Viruses |
| title | Ultrastructural Features of Alkhumra Hemorrhagic Fever Virus Infection of Cells Under In Vivo and In Vitro Conditions |
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