Gastric Emptying and Small Bowel Water Content after Administration of Grapefruit Juice Compared to Water and Isocaloric Solutions of Glucose and Fructose: A Four-Way Crossover MRI Pilot Study in Healthy Subjects

Grapefruit juice (GFJ) is known to affect the bioavailability of drugs in different ways. Despite the influence on gastrointestinal enzymes and transporters, the influence on gastrointestinal fluid kinetics is regarded to be relevant for the absorption of several drugs. Thus, it was the aim of this...

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Veröffentlicht in:Molecular pharmaceutics 2018-02, Vol.15 (2), p.548-559
Hauptverfasser: Grimm, Michael, Koziolek, Mirko, Saleh, Marwa, Schneider, Felix, Garbacz, Grzegorz, Kühn, Jens-Peter, Weitschies, Werner
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Sprache:eng
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