Screening study for potential lead compounds for natural product-based fungicides. I. Synthesis and in vitro evaluation of coumarins against Botrytis cinerea
An efficient, one-pot synthesis of angular and linear dihydropyranocoumarins, along with C-6 and C-8 prenylated coumarins is reported. These compounds, together with single- and furanocoumarins, were tested for their potential antifungal activity against the phytopathogen Botrytis cinerea Pers ex Fr...
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| Veröffentlicht in: | Pest management science 2004-09, Vol.60 (9), p.927-932 |
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| container_title | Pest management science |
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| creator | Daoubi, M Duran-Patron, R Hmamouchi, M Hernandez-Galan, R Benharref, A Collado, I.G |
| description | An efficient, one-pot synthesis of angular and linear dihydropyranocoumarins, along with C-6 and C-8 prenylated coumarins is reported. These compounds, together with single- and furanocoumarins, were tested for their potential antifungal activity against the phytopathogen Botrytis cinerea Pers ex Fr. The results show that furanocoumarins may be able to control the fungus B cinerea. |
| doi_str_mv | 10.1002/ps.891 |
| format | Article |
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I. Synthesis and in vitro evaluation of coumarins against Botrytis cinerea</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Daoubi, M ; Duran-Patron, R ; Hmamouchi, M ; Hernandez-Galan, R ; Benharref, A ; Collado, I.G</creator><creatorcontrib>Daoubi, M ; Duran-Patron, R ; Hmamouchi, M ; Hernandez-Galan, R ; Benharref, A ; Collado, I.G</creatorcontrib><description>An efficient, one-pot synthesis of angular and linear dihydropyranocoumarins, along with C-6 and C-8 prenylated coumarins is reported. These compounds, together with single- and furanocoumarins, were tested for their potential antifungal activity against the phytopathogen Botrytis cinerea Pers ex Fr. The results show that furanocoumarins may be able to control the fungus B cinerea.</description><identifier>ISSN: 1526-498X</identifier><identifier>EISSN: 1526-4998</identifier><identifier>DOI: 10.1002/ps.891</identifier><identifier>PMID: 15382508</identifier><identifier>CODEN: PMSCFC</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>antifungal activity ; antifungal properties ; Atoms & subatomic particles ; biochemical pathways ; Biological and medical sciences ; Biological Factors - chemical synthesis ; Biological Factors - toxicity ; Botrytis - drug effects ; Botrytis cinerea ; chemical reactions ; chemical structure ; Control ; coumarins ; Coumarins - chemical synthesis ; Coumarins - toxicity ; crop-protection agents ; Culture Techniques ; disease control ; Fundamental and applied biological sciences. Psychology ; fungal diseases of plants ; Fungal plant pathogens ; Fungi ; Fungicides, Industrial - chemical synthesis ; Fungicides, Industrial - toxicity ; Furocoumarins - chemical synthesis ; Furocoumarins - toxicity ; lead ; Lead content ; natural fungicides ; Natural products ; Pest Control, Biological - methods ; Pesticides ; Phytopathology. Animal pests. Plant and forest protection ; plant pathogenic fungi ; Protein Prenylation ; synthesis</subject><ispartof>Pest management science, 2004-09, Vol.60 (9), p.927-932</ispartof><rights>2004 Society of Chemical Industry</rights><rights>2004 INIST-CNRS</rights><rights>Copyright John Wiley and Sons, Limited Sep 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4591-b5cfd11964b1001b89fd4aaae25ccb5ae6f4665c72b73303dfd67cb213844eb43</citedby><cites>FETCH-LOGICAL-c4591-b5cfd11964b1001b89fd4aaae25ccb5ae6f4665c72b73303dfd67cb213844eb43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fps.891$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fps.891$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16031460$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15382508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daoubi, M</creatorcontrib><creatorcontrib>Duran-Patron, R</creatorcontrib><creatorcontrib>Hmamouchi, M</creatorcontrib><creatorcontrib>Hernandez-Galan, R</creatorcontrib><creatorcontrib>Benharref, A</creatorcontrib><creatorcontrib>Collado, I.G</creatorcontrib><title>Screening study for potential lead compounds for natural product-based fungicides. I. Synthesis and in vitro evaluation of coumarins against Botrytis cinerea</title><title>Pest management science</title><addtitle>Pest. Manag. Sci</addtitle><description>An efficient, one-pot synthesis of angular and linear dihydropyranocoumarins, along with C-6 and C-8 prenylated coumarins is reported. These compounds, together with single- and furanocoumarins, were tested for their potential antifungal activity against the phytopathogen Botrytis cinerea Pers ex Fr. The results show that furanocoumarins may be able to control the fungus B cinerea.</description><subject>antifungal activity</subject><subject>antifungal properties</subject><subject>Atoms & subatomic particles</subject><subject>biochemical pathways</subject><subject>Biological and medical sciences</subject><subject>Biological Factors - chemical synthesis</subject><subject>Biological Factors - toxicity</subject><subject>Botrytis - drug effects</subject><subject>Botrytis cinerea</subject><subject>chemical reactions</subject><subject>chemical structure</subject><subject>Control</subject><subject>coumarins</subject><subject>Coumarins - chemical synthesis</subject><subject>Coumarins - toxicity</subject><subject>crop-protection agents</subject><subject>Culture Techniques</subject><subject>disease control</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>fungal diseases of plants</subject><subject>Fungal plant pathogens</subject><subject>Fungi</subject><subject>Fungicides, Industrial - chemical synthesis</subject><subject>Fungicides, Industrial - toxicity</subject><subject>Furocoumarins - chemical synthesis</subject><subject>Furocoumarins - toxicity</subject><subject>lead</subject><subject>Lead content</subject><subject>natural fungicides</subject><subject>Natural products</subject><subject>Pest Control, Biological - methods</subject><subject>Pesticides</subject><subject>Phytopathology. Animal pests. 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I. Synthesis and in vitro evaluation of coumarins against Botrytis cinerea</title><author>Daoubi, M ; Duran-Patron, R ; Hmamouchi, M ; Hernandez-Galan, R ; Benharref, A ; Collado, I.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4591-b5cfd11964b1001b89fd4aaae25ccb5ae6f4665c72b73303dfd67cb213844eb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>antifungal activity</topic><topic>antifungal properties</topic><topic>Atoms & subatomic particles</topic><topic>biochemical pathways</topic><topic>Biological and medical sciences</topic><topic>Biological Factors - chemical synthesis</topic><topic>Biological Factors - toxicity</topic><topic>Botrytis - drug effects</topic><topic>Botrytis cinerea</topic><topic>chemical reactions</topic><topic>chemical structure</topic><topic>Control</topic><topic>coumarins</topic><topic>Coumarins - chemical synthesis</topic><topic>Coumarins - toxicity</topic><topic>crop-protection agents</topic><topic>Culture Techniques</topic><topic>disease control</topic><topic>Fundamental and applied biological sciences. 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| subjects | antifungal activity antifungal properties Atoms & subatomic particles biochemical pathways Biological and medical sciences Biological Factors - chemical synthesis Biological Factors - toxicity Botrytis - drug effects Botrytis cinerea chemical reactions chemical structure Control coumarins Coumarins - chemical synthesis Coumarins - toxicity crop-protection agents Culture Techniques disease control Fundamental and applied biological sciences. Psychology fungal diseases of plants Fungal plant pathogens Fungi Fungicides, Industrial - chemical synthesis Fungicides, Industrial - toxicity Furocoumarins - chemical synthesis Furocoumarins - toxicity lead Lead content natural fungicides Natural products Pest Control, Biological - methods Pesticides Phytopathology. Animal pests. Plant and forest protection plant pathogenic fungi Protein Prenylation synthesis |
| title | Screening study for potential lead compounds for natural product-based fungicides. I. Synthesis and in vitro evaluation of coumarins against Botrytis cinerea |
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