PtdIns(3)P accumulation in triple lipid-phosphatase-deletion mutants triggers lethal hyperactivation of the Rho1p/Pkc1p cell-integrity MAP kinase pathway

In the budding yeast Saccharomyces cerevisiae, the regulation of phosphatidylinositol 3-phosphate [PtdIns(3)P] is an essential function shared by the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2p and Sjl3p. The aim of this study was to gain further insight into...

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Veröffentlicht in:	Journal of cell science 2005-12, Vol.118 (23), p.5589-5601
Hauptverfasser:	Parrish, William R, Stefan, Christopher J, Emr, Scott D
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Survival - physiology Enzyme Activation - genetics Gene Expression Regulation, Enzymologic - drug effects Guanine Nucleotide Exchange Factors - metabolism MAP Kinase Signaling System - physiology Mitogen-Activated Protein Kinases - metabolism Models, Biological Mutation Phosphatidylinositol Phosphates - metabolism Phosphatidylinositol Phosphates - toxicity Phosphoric Monoester Hydrolases - drug effects Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Protein Kinase C - metabolism rho GTP-Binding Proteins - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae Proteins - drug effects Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Signal Transduction - drug effects Signal Transduction - physiology Temperature Time Factors
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